scholarly journals Morphological assessment of pancreatic islet hormone content following aerobic exercise training in rats with poorly controlled Type 1 diabetes mellitus

Islets ◽  
2014 ◽  
Vol 6 (2) ◽  
pp. e29221 ◽  
Author(s):  
Matthew W McDonald ◽  
Michael R Murray ◽  
Katharine E Hall ◽  
Earl G Noble ◽  
CW James Melling
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Type 1 Diabetes Mellitus ◽  
Pancreatic Islet ◽  
Aerobic Exercise Training ◽  
Islet Hormone ◽  
Morphological Assessment

A model of poorly controlled type 1 diabetes mellitus and its treatment with aerobic exercise training

2013 ◽  
Vol 39 (3) ◽  
pp. 226-235 ◽  
Author(s):  
C.W.J. Melling ◽  
K.N. Grisé ◽  
C.P. Hasilo ◽  
B. Fier ◽  
K.J. Milne ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Type 1 Diabetes Mellitus ◽  
Aerobic Exercise Training

scholarly journals High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Kenneth N. Grisé ◽  
T. Dylan Olver ◽  
Matthew W. McDonald ◽  
Adwitia Dey ◽  
Mao Jiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Type 1 Diabetes ◽  
Exercise Training ◽  
Type 1 Diabetes Mellitus ◽  
Autonomic Function ◽  
Experimental Models ◽  
Treadmill Running ◽  
Aerobic Exercise Training

Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX). Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9–17 mM) through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM.

scholarly journals Gene Therapy to Improve Pancreatic Islet Transplantation for Type 1 Diabetes Mellitus

2010 ◽  
Vol 6 (5) ◽  
pp. 274-284 ◽  
Author(s):  
Amy Hughes ◽  
Claire Jessup ◽  
Chris Drogemuller ◽  
Daisy Mohanasundaram ◽  
Clyde Milner ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

First Brazilian pancreatic islet transplantation in a patient with type 1 diabetes mellitus

2004 ◽  
Vol 36 (4) ◽  
pp. 1117-1118 ◽  
Author(s):  
F.G Eliaschewitz ◽  
C.A.M Aita ◽  
T Genzini ◽  
I.L Noronha ◽  
F.H Lojudice ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

Effects of a home-based aerobic exercise programme in children with type 1 diabetes mellitus

2011 ◽  
Vol 20 (5-6) ◽  
pp. 681-691 ◽  
Author(s):  
Ching-Hsiang Wong ◽  
Yi-Chien Chiang ◽  
Jackson Pui Man Wai ◽  
Fu-Sung Lo ◽  
Chao-Hsing Yeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Aerobic Exercise ◽  
Type 1 Diabetes Mellitus ◽  
Exercise Programme ◽  
Home Based
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