A model of poorly controlled type 1 diabetes mellitus and its treatment with aerobic exercise training

Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX). Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9–17 mM) through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM.

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Effects of a home-based aerobic exercise programme in children with type 1 diabetes mellitus

Journal of Clinical Nursing ◽

10.1111/j.1365-2702.2010.03533.x ◽

2011 ◽

Vol 20 (5-6) ◽

pp. 681-691 ◽

Cited By ~ 14

Author(s):

Ching-Hsiang Wong ◽

Yi-Chien Chiang ◽

Jackson Pui Man Wai ◽

Fu-Sung Lo ◽

Chao-Hsing Yeh ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Aerobic Exercise ◽

Type 1 Diabetes Mellitus ◽

Exercise Programme ◽

Home Based

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Effect of moderate exercise on renal changes and oxidative stress in ovariectomized rats with type 1 diabetes mellitus

Brazilian Journal of Biological Sciences ◽

10.21472/bjbs.061302 ◽

2019 ◽

Vol 6 (13) ◽

pp. 331-345 ◽

Cited By ~ 2

Author(s):

Mayane Oliveira Rebouças da Silveira ◽

Liliany Souza de Brito Amaral ◽

Samira Itana de Souza ◽

Halanna Rocha Ferraz ◽

Jéssica Alves Dias ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Renal Function ◽

Aerobic Exercise ◽

Type 1 Diabetes Mellitus ◽

Diabetic Rats ◽

Ovariectomized Rats ◽

And Oxidative Stress

This study evaluated the aerobic exercise effects of moderate and progressive intensity on renal function and structure, and oxidative stress in ovariectomized rats with type 1 diabetes mellitus induced by streptozotocin (STZ). Eighteen Wistar rats were divided into 3 groups: OSC - ovariectomized and sedentary control rats; OSD - ovariectomized and sedentary diabetic rats; and OTD - ovariectomized and trained diabetic rats. After induction of diabetes, the OTD group was submitted to eight weeks of exercise. Twenty-four hours after the last training session urine samples were collected. Blood samples and kidneys were collected after euthanasia for renal function analysis, histology, morphometry and oxidative stress. Our results have shown a reduction of the weight gain, increase of kidney weight and postprandial glycemia in diabetic rats. However, exercise decreased glycosuria and prevented the proteinuria in OTD group rats. Focal segmental glomerulosclerosis (FSGS), juxtamedullary glomerular tuft area, tubulointerstitial lesions (TIL), brush border loss and tubular cell debridement were reduced in OTD rats. In addition, exercise training decreased urinary and plasma concentrations of thiobarbituric acid reactive substance (TBARS). Our results demonstrate the beneficial effect of progressive aerobic exercise on proteinuria, glycosuria, and renal structure in ovariectomized diabetic rats, which may be mediated in part by reduction of oxidative stress.

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