scholarly journals High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Kenneth N. Grisé ◽  
T. Dylan Olver ◽  
Matthew W. McDonald ◽  
Adwitia Dey ◽  
Mao Jiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Type 1 Diabetes ◽  
Exercise Training ◽  
Type 1 Diabetes Mellitus ◽  
Autonomic Function ◽  
Experimental Models ◽  
Treadmill Running ◽  
Aerobic Exercise Training

Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX). Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9–17 mM) through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM.

A model of poorly controlled type 1 diabetes mellitus and its treatment with aerobic exercise training

2013 ◽  
Vol 39 (3) ◽  
pp. 226-235 ◽  
Author(s):  
C.W.J. Melling ◽  
K.N. Grisé ◽  
C.P. Hasilo ◽  
B. Fier ◽  
K.J. Milne ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Type 1 Diabetes Mellitus ◽  
Aerobic Exercise Training

Heart rate variability and circadian variations in type 1 diabetes mellitus

2006 ◽  
Vol 7 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Firat Kardelen ◽  
Gayaz Akcurin ◽  
Halil Ertug ◽  
Sema Akcurin ◽  
Iffet Bircan
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Circadian Variations

scholarly journals Heart rate variability in children with type 1 diabetes mellitus

2014 ◽  
Vol 32 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Camila Balsamo Gardim ◽  
Bruno Affonso P. de Oliveira ◽  
Aline Fernanda B. Bernardo ◽  
Rayana Loch Gomes ◽  
Francis Lopes Pacagnelli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Nervous System ◽  
Type 1 Diabetes Mellitus ◽  
Parasympathetic Nervous System ◽  
Vagal Activity ◽  
Mesh Terms

OBJECTIVE:To gather current information about the effects of type 1 diabetes mellitus on children's cardiac autonomic behavior.DATA SOURCES: The search of articles was conducted on PubMed, Ibecs, Medline, Cochrane, Lilacs, SciELO and PEDro databases using the MeSH terms: "autonomic nervous system", "diabetes mellitus", "child", "type 1 diabetes mellitus", "sympathetic nervous system" and "parasympathetic nervous system", and their respective versions in Portuguese (DeCS). Articles published from January 2003 to February 2013 that enrolled children with 9-12 years old with type 1 diabetes mellitus were included in the review.DATA SYNTHESIS: The electronic search resulted in four articles that approached the heart rate variability in children with type 1 diabetes mellitus, showing that, in general, these children present decreased global heart rate variability and vagal activity. The practice of physical activity promoted benefits for these individuals.CONCLUSIONS: Children with type 1 diabetes mellitus present changes on autonomic modulation, indicating the need for early attention to avoid future complications in this group.

Short-term heart rate complexity is reduced in patients with type 1 diabetes mellitus

2008 ◽  
Vol 119 (5) ◽  
pp. 1071-1081 ◽  
Author(s):  
Michal Javorka ◽  
Zuzana Trunkvalterova ◽  
Ingrid Tonhajzerova ◽  
Jana Javorkova ◽  
Kamil Javorka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Short Term ◽  
Heart Rate Complexity

scholarly journals Sensitivity, Specificity and Predictive Value of Heart Rate Variability Indices in Type 1 Diabetes Mellitus

2017 ◽  
Author(s):  
Anne Kastelianne França da Silva ◽  
Diego Giuliano Destro Christofaro ◽  
Aline Fernanda Barbosa Bernardo ◽  
Franciele Marques Vanderlei ◽  
Luiz Carlos Marques Vanderlei
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Predictive Value ◽  
Sensitivity Specificity

scholarly journals Asymptomatic ST-depression during exercise testing in children and adolescents with type 1 diabetes mellitus and autonomic dysfunction

2015 ◽  
Vol 18 (2) ◽  
pp. 54-60
Author(s):  
Dmitry Nikitich Laptev ◽  
Tamara Leonidovna Kuraeva ◽  
Galina Vladimirovna Ryabykina ◽  
Sergey Dmitrievich Polyakov ◽  
Irina Timofeevna Korneeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Autonomic Function ◽  
Cardiac Autonomic Function ◽  
Post Exercise ◽  
St Segment ◽  
Cardiovascular Morbidity And Mortality

Aim. The aim of this study was to investigate cardiac autonomic function as assessed by ST dynamics during and post-exercise in children and adolescents with type 1 diabetes mellitus (T1DM). Materials and methods. The study included 71 young patients with T1DM. The patients were aged 9?18 years and had no history of macrovascular disease or renal disease, including microalbuminuria. Cardiac autonomic function was assessed using cardiovascular tests and 24-h ECG monitoring with automatic calculation of QT interval and heart rate variability parameters. Each patient underwent the physical working capacity 170 test. Results. The prevalence of cardiovascular autonomic neuropathy (CAN) was 30.9%. The frequency of asymptomatic ST-segment depression increased during exercise in 10 (45.5%) patients with CAN (CAN+) compared with 9 (18.4%) patients without CAN (CAN-; p=0.042). During the recovery period, asymptomatic ST-segment depression was present in the first minute in 8 (36.4%) CAN+ patients compared with 1 (2%) CAN- patient (p=0.0003) and in the second minute in 5 (22.7%) CAN+ patients compared with 1 (2%) CAN- patient (p=0.0095). Conclusion. Children and adolescents with T1DM and impaired autonomic function have increased prevalence of asymptomatic ST-segment depression during and post-exercise. The presence of cardiovascular risk factors in children and adolescents with T1DM and CAN may contribute to the increased cardiovascular morbidity and mortality during adulthood in patients with T1DM.

scholarly journals Dynamics of heart rate variability analysed through nonlinear and linear dynamics is already impaired in young type 1 diabetic subjects

2016 ◽  
Vol 26 (7) ◽  
pp. 1383-1390 ◽  
Author(s):  
Naiara M. Souza ◽  
Thais R. Giacon ◽  
Francis L. Pacagnelli ◽  
Marianne P. C. R. Barbosa ◽  
Vitor E. Valenti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Type 1 Diabetes Mellitus ◽  
Autonomic Nervous ◽  
Young Subjects

AbstractBackgroundAutonomic diabetic neuropathy is one of the most common complications of type 1 diabetes mellitus, and studies using heart rate variability to investigate these individuals have shown inconclusive results regarding autonomic nervous system activation.AimsTo investigate the dynamics of heart rate in young subjects with type 1 diabetes mellitus through nonlinear and linear methods of heart rate variability.MethodsWe evaluated 20 subjects with type 1 diabetes mellitus and 23 healthy control subjects. We obtained the following nonlinear indices from the recurrence plot: recurrence rate (REC), determinism (DET), and Shanon entropy (ES), and we analysed indices in the frequency (LF and HF in ms2 and normalised units – nu – and LF/HF ratio) and time domains (SDNN and RMSSD), through analysis of 1000 R–R intervals, captured by a heart rate monitor.ResultsThere were reduced values (p<0.05) for individuals with type 1 diabetes mellitus compared with healthy subjects in the following indices: DET, REC, ES, RMSSD, SDNN, LF (ms2), and HF (ms2). In relation to the recurrence plot, subjects with type 1 diabetes mellitus demonstrated lower recurrence and greater variation in their plot, inter-group and intra-group, respectively.ConclusionYoung subjects with type 1 diabetes mellitus have autonomic nervous system behaviour that tends to randomness compared with healthy young subjects. Moreover, this behaviour is related to reduced sympathetic and parasympathetic activity of the autonomic nervous system.

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