Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models

Kathleen R Whiteman; Holly A Johnson; Michele F Mayo; Charlene A Audette; Christina N Carrigan; Alyssa LaBelle; Lawrence Zukerberg; John M Lambert; Robert J Lutz

doi:10.4161/mabs.27756

Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models

mAbs ◽

10.4161/mabs.27756 ◽

2014 ◽

Vol 6 (2) ◽

pp. 556-566 ◽

Cited By ~ 32

Author(s):

Kathleen R Whiteman ◽

Holly A Johnson ◽

Michele F Mayo ◽

Charlene A Audette ◽

Christina N Carrigan ◽

...

Keyword(s):

Lung Cancer ◽

Antitumor Activity ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Xenograft Models ◽

Antibody Drug ◽

Human Xenograft Models

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Abstract 1194: Discovery and preclinical development of a highly potent NaPi2b-targeted antibody-drug conjugate (ADC) with significant activity in patient-derived non-small cell lung cancer (NSCLC) xenograft models

10.1158/1538-7445.am2016-1194 ◽

2016 ◽

Cited By ~ 1

Author(s):

Natalya Bodyak ◽

Alex Yurkovetskiy ◽

Mao Yin ◽

Dmitry Gumerov ◽

Reddy Bollu ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Significant Activity ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Preclinical Development ◽

Xenograft Models ◽

Antibody Drug

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Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer

JCI Insight ◽

10.1172/jci.insight.128199 ◽

2019 ◽

Vol 4 (21) ◽

Cited By ~ 7

Author(s):

Louise A. Koopman ◽

Mikkel G. Terp ◽

Gijs G. Zom ◽

Maarten L. Janmaat ◽

Kirstine Jacobsen ◽

...

Keyword(s):

Lung Cancer ◽

Antitumor Activity ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Specific Antibody ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Abstract 1380: Antitumor activity of motesanib alone and in combination with chemotherapy in xenograft models of human non-small cell lung cancer

10.1158/1538-7445.am10-1380 ◽

2010 ◽

Cited By ~ 1

Author(s):

Beth Ziegler ◽

Stephen Kaufman ◽

Man Xu ◽

Hongyu Wang ◽

Dawn Weischun ◽

...

Keyword(s):

Lung Cancer ◽

Antitumor Activity ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Xenograft Models

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Abstract 832: An AXL-specific antibody-drug conjugate shows preclinical anti-tumor activity in non-small cell lung cancer, including EGFR-inhibitor resistant NSCLC

10.1158/1538-7445.am2018-832 ◽

2018 ◽

Cited By ~ 3

Author(s):

Louise A. Koopman ◽

Maarten L. Janmaat ◽

Kirstine Jacobsen ◽

Mikkel Green Terp ◽

Elke Gresnigt-van den Heuvel ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Specific Antibody ◽

Small Cell ◽

Egfr Inhibitor ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Anti Tumor Activity ◽

Antibody Drug

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A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2019.04.046 ◽

2019 ◽

Vol 513 (4) ◽

pp. 1083-1091 ◽

Cited By ~ 3

Author(s):

Muren Huhe ◽

Jiaxin Lou ◽

Yumeng Zhu ◽

Yu Zhao ◽

Ying Shi ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Anti Tumor Activity ◽

Antibody Drug

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Phase Ia Study of Anti-NaPi2b Antibody–Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non–Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-18-3965 ◽

2019 ◽

Vol 26 (2) ◽

pp. 364-372 ◽

Cited By ~ 3

Author(s):

David E. Gerber ◽

Jeffrey R. Infante ◽

Michael S. Gordon ◽

Sarah B. Goldberg ◽

Miguel Martín ◽

...

Keyword(s):

Lung Cancer ◽

Ovarian Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Platinum Resistant ◽

Antibody Drug

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Rovalpituzumab tesirine. Antibody-drug conjugate targeting delta-like protein 3 (DLL3), Treatment of small cell lung cancer

Drugs of the Future ◽

10.1358/dof.2018.043.04.2781506 ◽

2018 ◽

Vol 43 (4) ◽

pp. 261

Author(s):

J. Gras

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non–small-cell lung cancer xenograft models

Molecular Cancer ◽

10.1186/1476-4598-11-70 ◽

2012 ◽

Vol 11 (1) ◽

pp. 70 ◽

Cited By ~ 12

Author(s):

Angela Coxon ◽

Beth Ziegler ◽

Stephen Kaufman ◽

Man Xu ◽

Hongyu Wang ◽

...

Keyword(s):

Lung Cancer ◽

Antitumor Activity ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Xenograft Models

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Faculty Opinions recommendation of Therapy of Small Cell Lung Cancer (SCLC) with a Topoisomerase-I-inhibiting Antibody-Drug Conjugate (ADC) Targeting Trop-2, Sacituzumab Govitecan.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727782010.793565218 ◽

2019 ◽

Author(s):

Scott Kaufmann

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Topoisomerase I ◽

Small Cell ◽

Small Cell Lung ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

Download Full-text

Antitumor Activity of Bevacizumab Combined with Erlotinib in T790M Resistance Mutation Positive Non-Small Cell Lung Cancer Xenograft Models

Annals of Oncology ◽

10.1093/annonc/mdu348.13 ◽

2014 ◽

Vol 25 ◽

pp. iv421

Author(s):

K. Furugaki ◽

K. Yamamoto ◽

Y. Moriya ◽

K. Suda ◽

H. Mizuuchi ◽

...

Keyword(s):

Lung Cancer ◽

Antitumor Activity ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Resistance Mutation ◽

Small Cell ◽

Small Cell Lung ◽

Xenograft Models

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