Structural insights in the binding mode of neuropeptide Y at G protein coupled receptors and consequences for drug development

2018 ◽  
Vol 11 ◽  
Author(s):  
Annette G Beck-Sickinger
Keyword(s):  
Drug Development ◽  
Neuropeptide Y ◽  
G Protein ◽  
Binding Mode ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled ◽  
Structural Insights

Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development

2011 ◽  
Vol 32 (10) ◽  
pp. 591-600 ◽  
Author(s):  
Julia K. Archbold ◽  
Jack U. Flanagan ◽  
Harriet A. Watkins ◽  
Joseph J. Gingell ◽  
Debbie L. Hay
Keyword(s):  
Drug Development ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled ◽  
Structural Insights

Virally Encoded G Protein-Coupled Receptors: Targets for Potentially Innovative Anti-Viral Drug Development

2003 ◽  
Vol 4 (5) ◽  
pp. 431-441 ◽  
Author(s):  
J. Smit ◽  
C. Vink ◽  
D. Verzijl ◽  
P. Casarosa ◽  
A. Bruggeman ◽  
...  
Keyword(s):  
Drug Development ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Virally Encoded ◽  
G Protein Coupled

Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

Physiology ◽  
2008 ◽  
Vol 23 (6) ◽  
pp. 322-332 ◽  
Author(s):  
Kjell Fuxe ◽  
Daniel Marcellino ◽  
Diego Guidolin ◽  
Amina S. Woods ◽  
Luigi F. Agnati
Keyword(s):  
Drug Development ◽  
G Protein ◽  
Research Area ◽  
G Protein Coupled Receptors ◽  
Major Research ◽  
Receptor Mosaics ◽  
Different Types ◽  
Allosteric Mechanisms ◽  
Novel Drug ◽  
G Protein Coupled

Through an assembly of interacting GPCRs, heterodimers and high-order heteromers (termed receptor mosaics) are formed and lead to changes in the agonist recognition, signaling, and trafficking of participating receptors via allosteric mechanisms, sometimes involving the appearance of cooperativity. This field has now become a major research area, and this review deals with their physiology being integrators of receptor signaling in the CNS and their use as targets for novel drug development based on their unique pharmacology.

G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms

2013 ◽  
Vol 41 (1) ◽  
pp. 135-136 ◽  
Author(s):  
Bice Chini ◽  
Marco Parenti ◽  
David R. Poyner ◽  
Mark Wheatley
Keyword(s):  
G Protein ◽  
Full Range ◽  
G Protein Coupled Receptors ◽  
Model Systems ◽  
Future Goals ◽  
Receptor Research ◽  
Functional Mechanisms ◽  
G Protein Coupled ◽  
Structural Insights

The papers resulting from the recent Biochemical Society Focused Meeting ‘G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms’ held in Prato in September 2012 are introduced in the present overview. A number of future goals for GPCR (G-protein-coupled receptor) research are considered, including the need to develop biophysical and computational methods to explore the full range of GPCR conformations and their dynamics, the need to develop methods to take this into account for drug discovery and the importance of relating observations on isolated receptors or receptors expressed in model systems to receptor function in vivo.

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