Sequential Therapy with Tenofovir Plus Peg Interferon Enhances Innate and Adaptive Immunity Compared to Tenofovir Monotherapy in Chronic Hepatitis B Patients

2014 ◽  
Vol 05 (06) ◽  
Author(s):  
Nirupma Trehanpati Arshi Khanam
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Adaptive Immunity ◽  
Chronic Hepatitis B ◽  
Sequential Therapy ◽  
Innate And Adaptive Immunity

scholarly journals Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 216 ◽  
Author(s):  
Sayeh Ezzikouri ◽  
Mohammad Enamul Hoque Kayesh ◽  
Soumaya Benjelloun ◽  
Michinori Kohara ◽  
Kyoko Tsukiyama-Kohara
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Adaptive Immunity ◽  
Chronic Hepatitis B ◽  
Immune Modulation ◽  
Therapeutic Strategies ◽  
Functional Cure ◽  
Innate And Adaptive Immunity ◽  
Promising Target ◽  
Current Therapies

Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over 38 years, chronic HBV (CHB) infection remains a global health burden with around 257 million patients. The ideal treatment goal for CHB infection would be to achieve complete cure; however, current therapies such as peg-interferon and nucleos(t)ide analogs are unable to achieve the functional cure, the newly set target for HBV chronic infection. Considering the fact functional cure has been accepted as an endpoint in the treatment of chronic hepatitis B by scientific committee, the development of alternative therapeutic strategies is urgently needed to functionally cure CHB infection. A promising target for future therapeutic strategies is immune modulation to restore dysfunctional HBV-specific immunity. In this review, we provide an overview of the progress in alternative therapeutic strategies, including immune-based therapeutic approaches that enhance host innate and adaptive immunity to achieve and increase the functional cure from CHB infection.

scholarly journals Peg-Interferon Lambda Treatment Induces Robust Innate and Adaptive Immunity in Chronic Hepatitis B Patients

2017 ◽  
Vol 8 ◽  
Author(s):  
Sandra Phillips ◽  
Sameer Mistry ◽  
Antonio Riva ◽  
Helen Cooksley ◽  
Tanya Hadzhiolova-Lebeau ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Adaptive Immunity ◽  
Chronic Hepatitis B ◽  
Innate And Adaptive Immunity ◽  
Interferon Lambda

Effect of nucleoside analog-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B

2010 ◽  
Vol 40 (5) ◽  
pp. 461-469 ◽  
Author(s):  
Chiaki Okuse ◽  
Hiroshi Yotsuyanagi ◽  
Norie Yamada ◽  
Masaru Okamoto ◽  
Hiroki Ikeda ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Acute Exacerbation ◽  
Chronic Hepatitis B ◽  
Sequential Therapy ◽  
Nucleoside Analog

Factors associated with the effect of interferon-α sequential therapy in order to discontinue nucleoside/nucleotide analog treatment in patients with chronic hepatitis B

2015 ◽  
Vol 45 (12) ◽  
pp. 1195-1202 ◽  
Author(s):  
Akihiro Matsumoto ◽  
Hiroshi Yatsuhashi ◽  
Shinya Nagaoka ◽  
Yoshiyuki Suzuki ◽  
Tetsuya Hosaka ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Sequential Therapy ◽  
Interferon Α ◽  
Factors Associated ◽  
Nucleotide Analog

scholarly journals Sequential therapy with entecavir and PEG-INF in patients affected by chronic hepatitis B and high levels of HBV-DNA with non-D genotypes

2013 ◽  
Vol 20 (4) ◽  
pp. e11-e19 ◽  
Author(s):  
L. Boglione ◽  
A. D'Avolio ◽  
G. Cariti ◽  
M. G. Milia ◽  
M. Simiele ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Sequential Therapy ◽  
Hbv Dna

Entecavir and interferon-α sequential therapy in Japanese patients with hepatitis B e antigen-positive chronic hepatitis B

2012 ◽  
Vol 48 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Masaru Enomoto ◽  
Shuhei Nishiguchi ◽  
Akihiro Tamori ◽  
Sawako Kobayashi ◽  
Hiroki Sakaguchi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Sequential Therapy ◽  
Japanese Patients ◽  
Interferon Α ◽  
Hepatitis B E Antigen ◽  
Positive Chronic Hepatitis
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