Differentiation between Papillary Carcinoma and Adenomatous Nodule using Three-dimensional Nuclear Analysis is Useful for Morphologically Indeterminate Cases of Thyroid Tumor

2013 ◽  
Vol 04 (05) ◽  
Author(s):  
Washiya K Furutate S
1980 ◽  
Vol 66 (2) ◽  
pp. 273-275 ◽  
Author(s):  
Francesco Dallera ◽  
Roberto Gamoletti

A patient with erytharocytosis is described. No other evidence exists for polycythaemia vera or a known cause of secondary erythrocytosis in this patient, and management with phlebotomy resulted in temporary normalization of hematologic parameters. Subsequently a cold thyroid nodule was found which was then surgically removed and turned out to be a papillary carcinoma ( 2 cm) at histologic evaluation. Following thyroidectomy hematologic remission was observed which is still maintained 15 months after surgery. It seems to be the first reported case of erythrocytosis associated with thyroid tumor.


2008 ◽  
Vol 83 (10-12) ◽  
pp. 1879-1883 ◽  
Author(s):  
M.E. Sawan ◽  
A. Ibrahim ◽  
T.D. Bohm ◽  
P.P.H. Wilson

2010 ◽  
Vol 85 (7-9) ◽  
pp. 1027-1032 ◽  
Author(s):  
M.E. Sawan ◽  
B. Smith ◽  
E.P. Marriott ◽  
P.P.H. Wilson

Author(s):  
T.M. Myshunina ◽  
B.B. Guda ◽  
M.Yu. Bolgov ◽  
O.V. Kalinichenko

The aimwas to analyze the literature data on the TSH content in the blood serum of patients with differentiated thyroid carcinomas and to study the hormone content depending on the aggressiveness of the tumors, and also in the presence of some pathological changes in the extra-tumoral tissue that may affect the biological behavior of papillary carcinomas. Material and methods. A retrospective study of the cohort of patients who who had surgery for thyroid tumor. Results. The level of TSH in the serum of patients with papillary or follicular carcinomas is higher (but within the "normal" level) such in patients with nodular goiter. The highest level of hormone is recorded in the blood of women in the case of a combination of metastases in the lymph nodes with intra- and extrathyroid invasion, as well as in women over 45 with stage III/IV disease. In male patients, elevated TSH levels do not undergo significant modulations, depending on the metastatic and/or invasive properties of papillary carcinoma. The level of the hormone in the blood of women in the case of diagnosis in the extra-tumoral tissue of the gland expressed hyperplastic process or chronic thyroiditis is higher compared with patients who have not revealed pathomorphological changes in the gland tissue. Men also have an elevated level of TSH in the presence of chronic thyroiditis in the extra-tumoral tissue. When association of a tumor with adenoma or hyperplasia of the thyroid parenchyma, the content of tropic hormone does not differ from that of men from the comparison group; it is less when a single benign node or diffuse colloid goiter is present in the extra-tumoral tissue. Conclusions. In the blood of patients with thyroid carcinomas, especially in women with invasive papillary carcinomas, there is a higher level of TSH in the blood compared to that in patients with nodular goiter. The modulation of the content of trophic hormone can be affected by pathological changes in the extra-tumoral tissue that accompany the papillary carcinoma.  


1993 ◽  
Vol 129 (6) ◽  
pp. 573-578 ◽  
Author(s):  
Katsumi Iwase ◽  
Akio Nagasaka ◽  
Kanefusa Kato ◽  
Susumu Ohtani ◽  
Toru Tsujimura ◽  
...  

The intracellular localization of Cu/Zn- and Mn-superoxide dismutases (SOD), which catalyze the dismutation of superoxide radicals (O2−) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. The concentrations of both SODs in those tissues were measured also by a sandwich enzyme immunoassay technique. Copper/zinc-SOD in thyroid tissues were identified by immunocytochemical staining in most cases of papillary carcinoma and in some cases of other thyroid disorders. In normal follicular cells this enzyme is localized in the perinuclear cytoplasm, whereas in thyroid tumor or hyperplastic follicular cells it exists homogenously in cytoplasm. Manganese-SOD stained strongly in papillary carcinoma and papillary-growing cells in the thyroid tissue of adenoma and Graves' disease. The concentrations of Cu/Zn- and Mn-SOD in thyroid tumor tissues and hyperplastic follicular disorders were significantly higher than those in normal thyroid tissue when they were compared as a function of protein or deoxyribonucleic acid contents. The ratio of Mn-SOD to Cu/Zn-SOD was significantly higher only in papillary carcinoma, except for other thyroid disorders, as compared with that in the normal thyroid. In conclusion. SOD seems to be related to cell proliferation and differentiation in the thyroid follicular cell because Cu/Zn-SOD changes its localization in tumor and hyperplastic follicular cells and because the Mn-SOD concentration is increased in papillary carcinoma or papillary-growing cells.


1966 ◽  
Vol 25 ◽  
pp. 227-229 ◽  
Author(s):  
D. Brouwer

The paper presents a summary of the results obtained by C. J. Cohen and E. C. Hubbard, who established by numerical integration that a resonance relation exists between the orbits of Neptune and Pluto. The problem may be explored further by approximating the motion of Pluto by that of a particle with negligible mass in the three-dimensional (circular) restricted problem. The mass of Pluto and the eccentricity of Neptune's orbit are ignored in this approximation. Significant features of the problem appear to be the presence of two critical arguments and the possibility that the orbit may be related to a periodic orbit of the third kind.


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