Erythrocytosis Associated with Thyroid Tumor

1980 ◽  
Vol 66 (2) ◽  
pp. 273-275 ◽  
Author(s):  
Francesco Dallera ◽  
Roberto Gamoletti
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Thyroid Tumor ◽  
Polycythaemia Vera ◽  
Histologic Evaluation

A patient with erytharocytosis is described. No other evidence exists for polycythaemia vera or a known cause of secondary erythrocytosis in this patient, and management with phlebotomy resulted in temporary normalization of hematologic parameters. Subsequently a cold thyroid nodule was found which was then surgically removed and turned out to be a papillary carcinoma ( 2 cm) at histologic evaluation. Following thyroidectomy hematologic remission was observed which is still maintained 15 months after surgery. It seems to be the first reported case of erythrocytosis associated with thyroid tumor.

scholarly journals Thyroid papillary carcinoma in a 'hot' thyroid nodule

QJM ◽  
2013 ◽  
Vol 107 (6) ◽  
pp. 475-476 ◽  
Author(s):  
Y. C. Kuan ◽  
F. H. S. Tan
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Thyroid Papillary Carcinoma ◽  
Thyroid Papillary

Fine-needle aspiration of follicular variant of papillary carcinoma in a hyperfunctioning thyroid nodule

2001 ◽  
Vol 25 (1) ◽  
pp. 80-81 ◽  
Author(s):  
Sanjay Logani ◽  
Suzette Y. Osei ◽  
Virginia A. LiVolsi ◽  
Zubair W. Baloch
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Follicular Variant ◽  
Fine Needle

scholarly journals Papillary carcinoma of the thyroid in an autonomously functioning nodule

2003 ◽  
Vol 47 (6) ◽  
pp. 739-743 ◽  
Author(s):  
José Ulisses M. Calegaro ◽  
Maria Stella Oliveira Dias ◽  
Sung Hoon Bae ◽  
Sioeme da Silva Moraes ◽  
Enio de Freitas Gomes ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Present Report ◽  
Differentiated Thyroid Carcinoma ◽  
Left Lobe ◽  
Central Nucleus ◽  
Whole Body ◽  
Thyroid Uptake ◽  
Partial Suppression ◽  
Well Differentiated

The association of differentiated thyroid cancer and a functioning nodule is very low. We report on a case of papillary carcinoma in an autonomously functioning thyroid nodule in a 39 year-old female patient. The nodule extended to the whole right lobe and 131I scintigraphy has detected a ''hot'' nodule and a partial suppression of131I uptake in the left lobe. Serum TSH levels (RIA) were undetectable (<1.0µUI/mL), but total T3 (190ng/dL) and T4 (8.5µg/dL) were normal. The patient underwent a partial thyroidectomy and an adenomatous nodule was found with a small central nucleus (7mm) hosting a papillary carcinoma. Whole body scans detected only residual thyroid uptake and the patient was subsequently treated with 100mCi of 131I. The patient has been on replacement therapy with 150µg of L-thyroxine and free of tumor recurrence for 12 years after surgery. In conclusion: the present report confirms other published cases in which the presence of a ''hot'' thyroid nodule does not exclude the concomitance of a well-differentiated thyroid carcinoma.

scholarly journals Frequency & pattern of malignancy in solitary thyroid nodule

1970 ◽  
Vol 15 (1) ◽  
pp. 1-5
Author(s):  
Md Rafiqul Islam ◽  
AFM Ekramuddaula ◽  
MS Alam ◽  
MS Kabir ◽  
Md Delwar Hossain ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Histopathological Examination ◽  
Malignant Lesion ◽  
Medullary Carcinoma ◽  
College Hospital ◽  
Frequency Pattern ◽  
Cross Sectional ◽  
Female Ratio ◽  
Solitary Thyroid Nodule

This cross sectional study done in the department of Banghabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of July 2005 to October 2007 to determine frequency & pattern of malignancy in solitary thyroid nodule. For this study, 118 patients who were diagnosed as a case of malignancy in solitary thyroid nodule by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examination, were collected. In this study majority of the patients were within 21-40 years of age. Frequency of solitary thyroid nodule is more in female with male female ratio 1: 2.11 Majority of the nodules were firm (72.03%), others were hard (16.95%) and cystic (11.02%). Malignant lesion was more common in hard nodule (70%). Most of the nodules were cold (66.10%) among them 25.6% cases were malignant, followed by warm (30.5%) and hot (3.3%). No malignancy was found in hot nodule. FNAC showed colloid nodule (44%), cellular follicular lesion (29.66%), papillary carcinoma (12.7%), colloid degeneration (4.2%) and medullary carcinoma (1.6%) Out of 118 patients, histopathologically non malignant were 96 (81.35%) and malignant were 22(18.65%). Among malignant cases, 16 (72.72%) cases were papillary carcinoma, 4 (18.18%) cases were follicular carcinoma and 2(9.1%) cases were medullary carcinoma. Key words: Solitary thyroid nodule, FNAC, Papillary carcinoma, Follicular carcinomaDOI: 10.3329/bjo.v15i1.4303 Bangladesh J of Otorhinolaryngology 2009; 15(1): 1-5

scholarly journals Histopathological pattern of malignancy in solitary thyroid nodule

2012 ◽  
Vol 18 (1) ◽  
pp. 5-10 ◽  
Author(s):  
SM Nazmul Huque ◽  
Mohammad Idrish Ali ◽  
Md Mahmudul Huq ◽  
Sk Nurul Fattah Rumi ◽  
Md Abdus Sattar ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Significant Proportion ◽  
Cervical Lymphadenopathy ◽  
Follicular Carcinoma ◽  
Neck Surgery ◽  
Anaplastic Carcinoma ◽  
Female Ratio ◽  
Significant Difference ◽  
Solitary Thyroid Nodule

Objective: To find out relative frequency and type of malignancy in solitary thyroid nodule (STN).Methods: This cross sectional study done in the Department of Otolaryngology Head & Neck Surgery, Dhaka Medical College Hospital (DMCH), Dhaka and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period of July 2008 to June 2009. For this study, 118 patients who were admitted a case of solitary thyroid nodule for operation. Diagnosed the case by detailed history, clinical examination, investigations, analyzed data presented by various tables, graphs and figures. Total 118 patients were selected as per described criteria from the Department of otolaryngology and head-neck surgery DMCH & BSMMU, Dhaka from July 2008 to July 2009.Results: In this study of 118 patients of STN, majority of the patients were within 21-40 years age group with female predominance. In thyroid malignancy male and female ratio was 1:1.75. Among 118 cases of solitary thyroid nodule 22 cases were malignant. Out of 22 malignant cases, 16(73%) were papillary carcinoma, 4(18%) were follicular carcinoma and 2(9%) were anaplastic carcinoma. Thyroid swelling was the common presentation in all cases (100%), some patients also presented with other symptoms like cervical lymphadenopathy in 6 (5.08%) cases, dysphagia 2(1.69%) cases and hoarseness of voice 1(0.85%) case. Study showed very significant difference (p <0.01) between papillary and follicular carcinoma, highly significant difference (p<0.001) between papillary and anaplastic carcinoma. So, papillary carcinoma was more common among all thyroid malignancies in patients with solitary thyroid nodule.Conclusion: Significant proportion of solitary thyroid nodule (18.65%) was malignant. So, careful assessment of thyroid nodule is important for early diagnosis.DOI: http://dx.doi.org/10.3329/bjo.v18i1.10407Bangladesh J Otorhinolaryngol 2012; 18(1): 5-10

scholarly journals The Difficulty of Post-Operative Surveillance of Calcitonin Negative Medullary Thyroid Cancer

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A901-A901
Author(s):  
Emily Skutnik ◽  
Rachel Kinney ◽  
Rebecca Lopes ◽  
Chun Siu ◽  
Angela Magdaleno ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodule ◽  
Medullary Thyroid Cancer ◽  
Reference Range ◽  
Lower Lobe ◽  
Staging System ◽  
Thyroid Tumor ◽  
Clinical Relapse ◽  
Serum Calcitonin ◽  
Medullary Thyroid

Abstract Background: As a differentiated thyroid tumor, medullary thyroid cancer (MTC) typically maintains the secretory function of the c-cells with resultant increase in serum calcitonin level along with frequent elevations in serum chromogranin A (CgA) and carcinoembryonic antigen (CEA). Clinical Presentation: A 71-year-old female with history of multinodular goiter underwent a thyroid nodule biopsy after routine ultrasound surveillance revealed enlargement of two right lower lobe nodules compared with prior imaging. Fine needle aspiration (FNA) of one 3.1 x 1.9 x 2.7 cm right thyroid nodule revealed cellular material composed of spindle-shaped neoplastic cells, some of them with marked cytologic atypia, suspicious for a neuroendocrine tumor, specifically medullary thyroid carcinoma. A PET/CT scan was performed after injection of Gallium-68 dotatate radiotracer and revealed intense focal radiotracer activity in the approximately 2.5 x 2.1 cm right thyroid mid lower pole heterogeneous hypodense mass with tiny calcification inferiorly, consistent with the patient’s known tumor. There was no evidence of cervical octreotate avid metastatic lymphadenopathy and a chest x-ray showed no evidence of active pulmonary disease. The patient subsequently underwent a right partial thyroidectomy with isthmusectomy. Histopathology revealed a 2.8 x 1.9 x 1.9 cm neoplasm composed of spindle and polygonal cells growing in solid nests with neuroendocrine-type nuclei. Immunostains showed the tumor to be positive for AE1-AE3 cytokeratins, chromogranin, synaptophysin and CEA. It was focally positive for TTF-1 and calcitonin. Thyroglobulin and PAX-8 were negative. Using the AJCC 8th edition staging system, the tumor was staged a pT2Nx with margins uninvolved by carcinoma and no extrathyroidal extension or lymphatic invasion. Angioinvasion was present. Additional serum studies included a normal calcitonin value of &lt;2.0 pg/ml (reference range 0-5.1 pg/ml), CEA 2.6 ng/ml (reference range &lt;6.0 ng/ml), and a mildly elevated chromagranin A at 133 ng/ml (reference range 0-95 ng/ml). Plasma metanephrines, normetanephrines, vasoactive peptide, and glucagon levels were all unremarkable. Our patient’s surgical recovery was normal and two months later she remained asymptomatic without evidence of recurrence or metastasis. Discussion: The diagnosis and post-operative surveillance of medullary thyroid cancer is challenging; even more complicated is the rare case of calcitonin-negative MTC. The cause of calcitonin-negative MTC remains unclear. Further studies are needed for the discovery and development of novel biomarkers for post-operative surveillance and evaluation of clinical relapse.

scholarly journals Histopathological study of solitary nodules of thyroid

1970 ◽  
Vol 6 (4) ◽  
pp. 486-490 ◽  
Author(s):  
UN Khadilkar ◽  
P Maji
Keyword(s):  
Thyroid Nodule ◽  
Papillary Carcinoma ◽  
Thyroid Nodules ◽  
Medullary Carcinoma ◽  
Histopathological Study ◽  
Malignant Neoplasms ◽  
Solitary Nodule ◽  
Solitary Thyroid Nodule ◽  
Neoplastic Lesions ◽  
Microscopic Features

Objective: To determine the incidence of various thyroid disorders manifesting as Solitary Thyroid Nodule and also to evaluate the histomorphology of the lesions. Materials and methods: Hundred specimens of Solitary Thyroid Nodules were studied for gross characteristics, microscopic features, age and sex incidence. Results: Of the 100 cases of Solitary Thyroid Nodules, 66% were non neoplastic and 34% were neoplastic. Among the neoplasms, 21% were malignant and 13% were benign. The age incidence ranged from 20-50 years for non neoplastic lesions and 20-40 years for neoplasms. A female preponderance was seen for both non neoplastic and neoplastic conditions. The solitary nodules involved the right side of the thyroid more commonly than the left. Involutional colloid nodule was the predominant type of solitary nodule (52%). Among the malignant neoplasms, papillary carcinoma was the commonest solitary nodule (13%). One case each of hyalinising trabecular adenoma, columnar cell variant of papillary carcinoma and medullary carcinoma unusually presenting as solitary nodules were encountered in the present study. Conclusion: Histomorphologic evaluation of Solitary Thyroid Nodules presenting without a background setting of multinodular goiter is challenging and mandatory as the diagnoses ranges from the common non neoplastic lesions like involuting nodules to the rare neoplastic conditions like medullary carcinoma. Key words: Solitary Thyroid Nodule morphology, involuting nodule, medullary carcinoma doi: 10.3126/kumj.v6i4.1740   Kathmandu University Medical Journal (2008), Vol. 6, No. 4, Issue 24, 486-490

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