Non Alcoholic Wernicke’s Encephalopathy with Cortical Involvement in a Patient of Active Peptic Ulcer Disease

We report a 74-year-old man with Wernicke's encephalopathy (WE) whose only prior illness was peptic ulcer disease. Upper gastrointestinal endoscopy demonstrated gastric ulcer scars accompanied by marked deformity, without pathologic evidence of malignancy. WE due to peptic ulcer disease in previous reports was substantially associated with thiamine deficiency due to recurrent vomiting or surgical procedures. In our case, however, there was no history of vomiting or gastrointestinal surgery. Besides, we thoroughly ruled out other known clinical settings related to WE. There is the possibility that peptic ulcer disease itself provoked thiamine deficiency due to malabsorption.

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Risk of Postoperative Upper Gastrointestinal Tract Hemorrhage in Patients With Active Peptic Ulcer Disease Undergoing Nonulcer Surgery

Archives of Internal Medicine ◽

10.1001/archinte.1993.00410180095011 ◽

1993 ◽

Vol 153 (18) ◽

pp. 2141

Author(s):

Ralph K. Della Ratta

Keyword(s):

Peptic Ulcer ◽

Gastrointestinal Tract ◽

Peptic Ulcer Disease ◽

Upper Gastrointestinal Tract ◽

Ulcer Disease ◽

Active Peptic Ulcer ◽

Upper Gastrointestinal

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Active Peptic Ulcer Disease in Patients with Hepatitis C Virus-Related Cirrhosis: The Role ofHelicobacter pyloriInfection and Portal Hypertensive Gastropathy

Canadian Journal of Gastroenterology ◽

10.1155/2004/150674 ◽

2004 ◽

Vol 18 (8) ◽

pp. 521-524 ◽

Cited By ~ 13

Author(s):

Maria Dore ◽

Daniela Mura ◽

Stefania Deledda ◽

Emmanouil Maragkoudakis ◽

Antonella Pironti ◽

...

Keyword(s):

Peptic Ulcer ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Peptic Ulcer Disease ◽

Portal Hypertensive Gastropathy ◽

Ulcer Disease ◽

Compensated Cirrhosis ◽

Breath Testing ◽

Active Peptic Ulcer ◽

H Pylori

BACKGROUND & AIM:The relationship betweenHelicobacter pyloriinfection and peptic ulcer disease in cirrhosis remains controversial. The purpose of the present study was to investigate the role ofH pyloriinfection and portal hypertension gastropathy in the prevalence of active peptic ulcer among dyspeptic patients with compensated hepatitis C virus (HCV)-related cirrhosis.METHODS:Patients undergoing upper endoscopy with compensated HCV-related cirrhosis were enrolled. Child-Pugh's score was determined at the entry. Variceal size was measured endoscopically and the severity of portal hypertensive gastropathy was graded.H pyloriinfection status was determined by urea breath testing and/or histology.RESULTS:A total of 178 patients positive for HCV (A and B Child-Pugh's score) were prospectively included. The prevalence ofH pyloriinfection was 43%. An active peptic ulcer was found in 14 patients (8%) and was significantly more common among those withH pyloriinfection (16% versus 2% inH pyloriuninfected patients, odds ratio: 8.0). No association was observed betweenH pyloriinfection and variceal size, or hypertensive gastropathy.CONCLUSIONS:Patients with compensated cirrhosis andH pyloriinfection showed higher risk of developing a peptic ulcer. Clinical relevance of this result would be that dyspeptic patients with HCV-related cirrhosis may benefit from preventive screening and eradication ofH pylori, especially those with features of insufficient hemostasis.

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