scholarly journals Therapeutic Effects of Intra-articular Botulinum Toxin Type A in Knee Osteoarthritis

2016 ◽  
Vol 5 (4) ◽  
Author(s):  
Wang Sheng Lin ◽  
Chen Liang Chou
2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989586 ◽  
Author(s):  
Shuchao Zhai ◽  
Botao Huang ◽  
Kai Yu

Objective A systematic review and meta-analysis was carried out to evaluate the efficacy and safety of Botulinum Toxin Type A in painful knee osteoarthritis. Methods The EMBASE and MEDLINE databases were searched to identify randomized controlled trials (RCTs) of Botulinum Toxin Type A in the treatment of painful knee osteoarthritis. The references of included literature were also searched. Results Five articles involving 5 RCTs including 314 patients were included in this analysis. There was a significant difference between Botulinum Toxin Type A and placebo in the visual analog scale (VAS) pain scale and Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) questionnaire score in both the short-term (≤4 weeks) and long-term (≥8 weeks) treatment period. There were no serious adverse events in the Botulinum Toxin Type A groups. Conclusions This meta-analysis suggests that Botulinum Toxin Type A is effective and safe in the painful knee OA treatment. However, high-quality randomized controlled studies are still needed to further confirm our findings.


Author(s):  
Adilson Tolfo de Oliveira ◽  
Sylvia de Araújo Paes-Souza ◽  
Marco Antonio Cavalcanti Garcia ◽  
Claudia Trindade Mattos ◽  
Matilde da Cunha Gonçalves Nojima

PM&R ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. S138-S139
Author(s):  
Carmen Eudelia Cortés Corral ◽  
Lilia Isabel ◽  
Correa Márquez ◽  
María Yolanda ◽  
Zambrano Muñoz ◽  
...  

Toxicon ◽  
2019 ◽  
Vol 165 ◽  
pp. 69-77 ◽  
Author(s):  
Sharif Najafi ◽  
Ehsan Sanati ◽  
Mahsa Khademi ◽  
Fateme Abdorrazaghi ◽  
Reza Kazempoor Mofrad ◽  
...  

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Wanying Chen ◽  
Xiaoyu Zhang ◽  
Yingying Xu ◽  
Zemin Xu ◽  
Haiyan Qin ◽  
...  

Abstract Objectives Our study aimed to explore the clinical therapeutic effects of ultrasound-guided five-point injection of botulinum toxin type A for patients with trapezius hypertrophy. Methods Twenty female patients diagnosed with trapezius hypertrophy were enrolled in this study. The thicknesses of the trapezius muscle were measured by using the ultrasound scanner to locate the thickest point of trapezius, followed by labelling the other four points around the first point. Botulinum toxin type A was injected bilaterally (50 IU/side, 5 points/side) in the trapezius muscle of these patients. The surgery effects were evaluated by thicknesses of the trapezius muscle, intramuscular needle electromyographic and electroneurographic examinations, appearance changes and patients’ satisfactions. Results Statistically significant differences in thicknesses of the trapezius muscle were observed at 4 weeks (p < 0.001), 12 weeks (p < 0.001), 20 weeks (p < 0.001), 28 weeks (p = 0.011), 36 weeks (p = 0.022), and 44 weeks (p = 0.032) after surgery. The latencies of trapezius muscle became longer at 12 weeks after surgery (left: 2.40 ms, right: 2.53 ms vs. left: 1.75 ms, right: 2.00 ms). Electroneurographic results showed amplitude reduction of compound muscle action potentials (CMAPs) at 12 weeks after surgery (left: 1.91 uV, right: 3.10 uV vs. left: 15.00 uV, right: 15.40 uV). Obvious appearance changes were revealed at 12 weeks after surgery. All of 80% patients were very satisfied, 15% patients were relatively satisfied, and 5% patients were not satisfied with the surgery. Conclusion Ultrasound-guided five-point injection of botulinum toxin type A might be effective for patients with trapezius hypertrophy.


PM&R ◽  
2010 ◽  
Vol 2 (4) ◽  
pp. 268-276 ◽  
Author(s):  
Andrea J. Boon ◽  
Jay Smith ◽  
Diane L. Dahm ◽  
Eric J. Sorenson ◽  
Dirk R. Larson ◽  
...  

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