Individual Risk Detection of Developing Cognitive Decline and Dementia in Adults with Down’s Syndrome

2017 ◽  
Vol 03 (01) ◽  
Author(s):  
Federico Licastro ◽  
Elisa Porcellini
Keyword(s):  
Cognitive Decline ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Individual Risk ◽  
Risk Detection

scholarly journals An Examination of the Severe Impairment Battery as a Measure of Cognitive Decline in Clients with Down's Syndrome

2002 ◽  
Vol 6 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Karen McKenzie ◽  
Cyan Harte ◽  
Elaine Sinclair ◽  
Edith Matheson ◽  
Shona Patrick ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Severe Impairment Battery ◽  
Severe Impairment

Macrocytosis and Cognitive Decline in Down's Syndrome

1986 ◽  
Vol 148 (4) ◽  
pp. 482-483 ◽  
Author(s):  
R. W. Lansdall Welfare ◽  
K. E. Hewitt
Keyword(s):  
Cognitive Decline ◽  
Down's Syndrome ◽  
Down’S Syndrome

Empirical Validation of Risk Screening for Down's Syndrome

1996 ◽  
Vol 3 (4) ◽  
pp. 185-187 ◽  
Author(s):  
N J Wald ◽  
A K Hackshaw ◽  
W Huttly ◽  
A Kennard
Keyword(s):  
Maternal Age ◽  
Risk Group ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maternal Serum ◽  
Individual Risk ◽  
Triple Test ◽  
Risk Estimates ◽  
Screening Performance ◽  
Predicted Risk

Objective— To validate individual risk estimates in antenatal serum screening for Down's syndrome. Methods— Women screened for Down's syndrome using maternal serum a fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotrophs (hCG) with maternal age (the triple test) or AFP, uE3, free β subunit and free a subunit of hCG with maternal age (the quadruple test) were grouped according to their predicted risk of having an affected pregnancy. The mean predicted risk in each category was then compared with the observed prevalence based on the number of affected and unaffected pregnancies in each category. Subjects— About 100 000 pregnant women screened for Down's syndrome from 1989 to 1995. Results— There was close agreement between the predicted term risk and the prevalence at birth for both the triple test and the quadruple test. For example, with the quadruple test the predicted risk in the highest risk group was 1 in 3.3 and the prevalence was 1 in 2.6; in the lowest risk group these were 1 in 3000 and 1 in 2300 respectively. Conclusion— Risk estimates based on multiple marker screening for Down's syndrome are accurate. The technique used to demonstrate this is simple and offers a useful empirical check on screening performance.

Hashimoto encephalopathy and antibodies against dimethylargininase-1: A rare cause of cognitive decline in a pediatric Down's syndrome patient

2011 ◽  
Vol 113 (8) ◽  
pp. 678-679 ◽  
Author(s):  
Verhelst Helene ◽  
Verloo Patrick ◽  
De Paepe Boel ◽  
Beatrice Gini ◽  
Bonetti Bruno ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Syndrome Patient ◽  
Hashimoto Encephalopathy

Sequence of cognitive decline in dementia in adults with Down's syndrome

2000 ◽  
Vol 44 (6) ◽  
pp. 654-665 ◽  
Author(s):  
D. A. Devenny ◽  
S. J. Krinsky‐McHale ◽  
G. Sersen ◽  
W. P. Silverman
Keyword(s):  
Cognitive Decline ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals Screening for Down's syndrome based on individual risk.

BMJ ◽  
1991 ◽  
Vol 303 (6802) ◽  
pp. 551-553 ◽  
Author(s):  
M Lewis ◽  
M J Faed ◽  
P W Howie
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Individual Risk

AGEING AND COGNITIVE DECLINE IN PEOPLE WITH DOWN’S SYNDROME

1997 ◽  
Vol 43 (85) ◽  
pp. 79-84 ◽  
Author(s):  
Wilma C. S. Jordens ◽  
Heleen M. Evenhuis ◽  
Cees G. C. Janssen
Keyword(s):  
Cognitive Decline ◽  
Down's Syndrome ◽  
Down’S Syndrome
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