AbstractWe analyse the computational complexity of type inference for untyped λ-terms in the second-order polymorphic typed λ-calculus (F2) invented by Girard and Reynolds, as well as higher-order extensions F3, F4, …, Fω proposed by Girard. We prove that recognising the F2-typable terms requires exponential time, and for Fω the problem is non-elementary. We show as well a sequence of lower bounds on recognising the Fk-typable terms, where the bound for Fk+1 is exponentially larger than that for Fk.The lower bounds are based on generic simulation of Turing Machines, where computation is simulated at the expression and type level simultaneously. Non-accepting computations are mapped to non-normalising reduction sequences, and hence non-typable terms. The accepting computations are mapped to typable terms, where higher-order types encode reduction sequences, and first-order types encode the entire computation as a circuit, based on a unification simulation of Boolean logic. A primary technical tool in this reduction is the composition of polymorphic functions having different domains and ranges.These results are the first nontrivial lower bounds on type inference for the Girard/Reynolds system as well as its higher-order extensions. We hope that the analysis provides important combinatorial insights which will prove useful in the ultimate resolution of the complexity of the type inference problem.