This paper is devoted to the study of the quasi-total strong differential of a graph, and it is a contribution to the Special Issue “Theoretical computer science and discrete mathematics” of Symmetry. Given a vertex x∈V(G) of a graph G, the neighbourhood of x is denoted by N(x). The neighbourhood of a set X⊆V(G) is defined to be N(X)=⋃x∈XN(x), while the external neighbourhood of X is defined to be Ne(X)=N(X)∖X. Now, for every set X⊆V(G) and every vertex x∈X, the external private neighbourhood of x with respect to X is defined as the set Pe(x,X)={y∈V(G)∖X:N(y)∩X={x}}. Let Xw={x∈X:Pe(x,X)≠⌀}. The strong differential of X is defined to be ∂s(X)=|Ne(X)|−|Xw|, while the quasi-total strong differential of G is defined to be ∂s*(G)=max{∂s(X):X⊆V(G)andXw⊆N(X)}. We show that the quasi-total strong differential is closely related to several graph parameters, including the domination number, the total domination number, the 2-domination number, the vertex cover number, the semitotal domination number, the strong differential, and the quasi-total Italian domination number. As a consequence of the study, we show that the problem of finding the quasi-total strong differential of a graph is NP-hard.
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