scholarly journals IGF-1 Signaling is Essential for Differentiation of Mesenchymal Stem Cells for Peak Bone Mass

Bone Research ◽  
2013 ◽  
Vol 1 (2) ◽  
pp. 186-194 ◽  
Author(s):  
Janet L. Crane ◽  
Luo Zhao ◽  
Joseph S. Frye ◽  
Lingling Xian ◽  
Tao Qiu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Mass ◽  
Peak Bone Mass

scholarly journals Restoration of Bone Mass and Strength in Glucocorticoid-Treated Mice by Systemic Transplantation of CXCR4 and Cbfa-1 Co-Expressing Mesenchymal Stem Cells

2009 ◽  
Vol 24 (5) ◽  
pp. 837-848 ◽  
Author(s):  
Chun-Yang Lien ◽  
Kevin Chih-Yuan Ho ◽  
Oscar K Lee ◽  
Gordon W Blunn ◽  
Yeu Su
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Mass

scholarly journals Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass

2012 ◽  
Vol 18 (3) ◽  
pp. 456-462 ◽  
Author(s):  
Min Guan ◽  
Wei Yao ◽  
Ruiwu Liu ◽  
Kit S Lam ◽  
Jan Nolta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Formation ◽  
Bone Mass ◽  
Increase Bone Mass

scholarly journals Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

2012 ◽  
Vol 18 (7) ◽  
pp. 1095-1101 ◽  
Author(s):  
Lingling Xian ◽  
Xiangwei Wu ◽  
Lijuan Pang ◽  
Michael Lou ◽  
Clifford J Rosen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Mass

scholarly journals Phactr1 Negatively Regulates Bone Mass By Inhibiting Osteogenesis And Promoting Adipogenesis of BMSCs Via RhoA/ROCK2

2021 ◽  
Author(s):  
Wei Lin ◽  
Zhipeng Chen ◽  
Xiaoyi Mo ◽  
Shengli Zhao ◽  
Zhenxing Wen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Bone Mass ◽  
Osteogenic Differentiation ◽  
Adipogenic Differentiation ◽  
Regulatory Factor

Abstract Background: The imbalance between osteogenic and adipogenic differentiation of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) is involved in the occurrence and development of Osteoporosis (OP). Previous studies have indicated the potential of phosphatase and actin regulatory factor 1 (Phactr1) in regulating osteogenic and adipogenic differentiation of BMSCs.The present study aims to investigate The Function and Mechanism of Phactr1 in regulating osteogenic and adipogenic Differentiation of BMSCs.Results: Phactr1 increased in both bone and adipose tissue of OP rats. During osteogenic differentiation , Phactr1 decreased and active RhoA, ROCK2 increased, while overexpression Phactr1 inhibits the increase of Runx2. Phactr1 increased and active RhoA decreased, ROCK2 did not changed during adipogenic differentiation, knockdown Phactr1 inhibits the increase of C/EBPα. Phactr1 and ROCK2 were combined in osteogenic differentiation, but not in adipogenic differentiation. By using KD025, the decrease of Phactr1 and the increase of Runx2 were inhibited respectively in osteogenic differentiation. Meanwhile, when ROCK2 was inhibited, Phactr1,C/EBPα were significantly increased in adipogenic differentiation.Conclusions: These findings indicated that Phactr1 negatively regulates bone mass by inhibiting osteogenesis and promoting adipogenesis of BMSCs by activating RhoA/ROCK2.

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