scholarly journals INFLUENCE OF POST-OPERATIVE INSTRUCTIONS ON WOUND HEALING. A RANDOMIZED, SINGLE-BLINDED CLINICAL TRIAL.

2020 ◽  
Vol 42 (1) ◽  
pp. 1-9
Author(s):  
Edetanlen Benlance Ekaniyere ◽  
Aggrey-Nwanguma Ifeoma
Keyword(s):  
Clinical Trial ◽  
Wound Healing

scholarly journals MEBO versus topical Diltiazem versus a combination of both ointments in the treatment of acute anal fissure: a randomized clinical trial protocol

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohamad Hadi El Charif ◽  
Samer Doughan ◽  
Rawya Kredly ◽  
Sara Kassas ◽  
Rayan Azab ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Anal Fissure ◽  
Topical Therapy ◽  
Trial Registration ◽  
Clinical Trial Registration ◽  
Anal Fissures ◽  
Link Type ◽  
Anorectal Region ◽  
Registration Date

Abstract Background Anal fissure is a common complication of the anorectal region and one of the most reported causes of anal pain. Acute anal fissure can be cured by surgery or medical treatment. There is an increase in the use of topical therapy for the treatment of anal fissures. A common topical drug used is Diltiazem (DTZ), a calcium-channel blocker, which relaxes the anal sphincter and thus promotes healing of the anal fissure. Moist exposed burn ointment (MEBO) is an ointment that is effective for the treatment of burns and wound healing and is becoming popular in the treatment of anal fissures. Methods This is a 1:1:1 randomized, controlled, parallel design, with endpoint measures of change in pain score, wound healing, defecation strain score and patient’s global impression of improvement. The study will be conducted at AUBMC over a 10-week period. Patients will be randomized to three treatment arms: MEBO, Diltiazem, and a combination of MEBO and Diltiazem ointments. Discussion The results of this study will allow physicians to assess the efficacy and safety of MEBO in the treatment of acute anal fissure, and also in comparison to Diltiazem. This trial will generate evidence-based conclusions regarding the use of a herbal/natural-based product (MEBO ointment) for the treatment of anal fissures. Trial registration ClinicalTrials.gov Identifier NCT04153032. Clinical Trial Registration Date: 06-NOVEMBER-2019.

447-P: The Efficacy and Safety Trial of ENERGI-F703 in Diabetic Wound Healing: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Clinical Trial

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 447-P
Author(s):  
GUANG-HUAR YOUNG ◽  
JIUN-TSAI LIN ◽  
YI-FANG CHENG ◽  
HAN-MIN CHEN ◽  
CHUN-FANG HUANG
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Diabetic Wound ◽  
Phase 2 ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Phase 2 Clinical Trial ◽  
Diabetic Wound Healing

scholarly journals Topical Insulin Accelerates Wound Healing in Diabetes by Enhancing the AKT and ERK Pathways: A Double-Blind Placebo-Controlled Clinical Trial

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36974 ◽  
Author(s):  
Maria H. M. Lima ◽  
Andréa M. Caricilli ◽  
Lélia L. de Abreu ◽  
Eliana P. Araújo ◽  
Fabiana F. Pelegrinelli ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo

Wound healing after craniotomy: a randomized trial comparing scalp clips to artery forceps for scalp hemostasis

2009 ◽  
Vol 111 (6) ◽  
pp. 1175-1178 ◽  
Author(s):  
Peter Langford ◽  
Rory Wolfe ◽  
R. Andrew Danks
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Randomized Trial ◽  
Tissue Damage ◽  
The Self ◽  
Delayed Wound Healing ◽  
Prospective Randomized Clinical Trial ◽  
Skin Edge ◽  
Significant Difference ◽  
Artery Forceps

Object In this prospective randomized clinical trial, investigators looked at wound healing after craniotomy. The hypothesis was that the self-closing plastic scalp clips used for hemostasis on the skin edge might lead to localized microscopic tissue damage and subsequent delayed wound healing. Methods The trial consisted of 2 arms in which different methods were used to secure scalp hemostasis: 1) the routinely used plastic clips (Scalpfix, Aesculap); and 2) the older method of artery forceps placed on the galea. Participants were restricted to those > 16 years of age undergoing craniotomies expected to last > 2 hours. Repeat operations were not included. One hundred fifty patients were enrolled. They were visited at 3 and 6 weeks postoperatively by an observer blinded to the method used, and the wounds were assessed for macroscopic epithelial closure, signs of infection, and hair regrowth by using a predefined assessment scale. Results The results showed no significant difference in wound healing between the 2 groups at either 3 weeks (OR 0.55, 95% CI 0.27–1.11; p = 0.09) or 6 weeks (OR 0.79, 95% CI 0.39–1.58; p = 0.50). The length of operation was found to be a significant factor affecting wound healing at 6 weeks (OR/hour 0.68, 95% CI 0.51–0.92; p = 0.01). Conclusions The use of Aesculap Scalpfix self-retaining plastic scalp clips on the skin edge during craniotomy surgery does not appear to affect wound healing significantly to the postoperative 6-week mark.

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