Influence of red bone marrow allotransplantation on neuron-specific (NSE) and histamine-containing lymph node cells

2021 ◽  
pp. 246-249
Author(s):  
V. O. Romanov ◽  
◽  
L. A. Lyubovtseva ◽  
O. V. Vorob'eva ◽  
L. P. Romanova ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Red Bone Marrow ◽  
Lymph Node Cells

Evidence for the involvement of a bone marrow-derived cell population in the immune expulsion ofTrichinella spiralis

Parasitology ◽  
1977 ◽  
Vol 74 (3) ◽  
pp. 225-234 ◽  
Author(s):  
D. Wakelin ◽  
Margaret M. Wilson
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Cell Population ◽  
Mesenteric Lymph Node ◽  
Trichinella Spiralis ◽  
Mesenteric Lymph ◽  
Lymph Node Cells

When mice were irradiated immediately before infection withTrichinella spiralisthere was a profound and long-lasting interference with their ability to expel adult worms from the intestine. Irradiation given after the fifth day of infection was progressively less effective in this respect. The ability to expel worms was not restored when mesenteric lymph node cells (MLNC) were transferred (a) on the day of infection in mice irradiated one day previously, or (b) on day 7 of an infection in mice irradiated on day 6, even though the MLNC transferred immunity to intact recipients. Transfer of bone marrow (BM) alone was also without effect. However, worm explusion was restored if, following irradiation and injection of BM, 10 days were allowed for BM differentiation before transfer of MLNC. This restoration was effective even after lethal levels of irradiation and was clearly dependent upon a donor-derived BM component cooperating with, or responding to, the activity of the transferred MLNC. The possibility that the BM component is non-lymphoid in nature is discussed.

scholarly journals Truncated mu (mu') chains in murine IgM. Evidence that mu' chains lack variable regions.

1985 ◽  
Vol 162 (6) ◽  
pp. 1862-1877 ◽  
Author(s):  
R Marks ◽  
M J Bosma
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Molecular Mass ◽  
Tumor Cells ◽  
Isoelectric Focusing ◽  
Bone Marrow Cells ◽  
Normal Serum ◽  
Antigenic Determinants ◽  
Variable Regions ◽  
Lymph Node Cells

Secreted IgM was shown to contain truncated mu (mu') chains with an apparent molecular mass of approximately 55 kD. The estimated percentage of IgM heavy (H) chains in the mu' form ranged from less than or equal to 1% in the case of one tumor IgM protein (104E) to greater than or equal to 30% in normal serum IgM. Serum mu' chains lacked antigenic determinants characteristic of immunoglobulin variable regions and showed a restricted isoelectric focusing pattern compared with that of conventional mu chains. Intracellular mu' chains were readily detected in bone marrow cells but not in spleen or lymph node cells; mu' chains were also detected in IgM-producing tumor cells and in a hybridoma cell line that deleted its productive mu allele. These results predict irregularities in IgM structure and recall an old controversy concerning the valence of IgM molecules.

scholarly journals A Method of Reducing the Incidence of the Secondary Syndrome in Allogenic Marrow Transplantation

Blood ◽  
1963 ◽  
Vol 22 (1) ◽  
pp. 44-52 ◽  
Author(s):  
GEORGES MATHÉ ◽  
JEAN-LOUIS AMIEL ◽  
LÉON SCHWARZENBERG ◽  
ANNE-MARIE MERY ◽  
F. Lapeyraque
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Marrow Transplantation ◽  
Clinical Medicine ◽  
Bone Marrow Cells ◽  
Allogenic Bone ◽  
Allogenic Bone Marrow ◽  
Lymph Node Cells ◽  
Bone Marrow Grafting ◽  
Marrow Cells

Abstract Preservation of a graft of lymph node cells or semi-allogenic bone marrow cells at 37 C. in Tyrode’s solution for 2 hours, which reduces the percentage of cells not permeable to eosin by half, has a statistically significant reducing effect on the frequency of acute or chronic secondary syndromes which occur in irradiated recipients. Preservation at 18 C. for 6 hours, which in the same way increases the percentage of cells permeable to eosin, does not have the same effect. These two methods of preserving bone marrow cells do not appreciably reduce the myeloid-restoring capacity of compatible or incompatible irradiated recipients. Application of these results to bone marrow grafting in clinical medicine is discussed.

scholarly journals BONE MARROW AS SOURCE OF CELLS IN REACTIONS OF CELLULAR HYPERSENSITIVITY

1968 ◽  
Vol 128 (6) ◽  
pp. 1437-1449 ◽  
Author(s):  
David M. Lubaroff ◽  
Byron H. Waksman
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Skin Test ◽  
Skin Tests ◽  
Skin Reactions ◽  
Lewis Rats ◽  
Lymph Node Cells ◽  
Lymphocyte Transfer ◽  
Spleen And Lymph Nodes

The precise origin of cells infiltrating tuberculin skin reactions was studied with the technique of immunofluorescence. Thymectomized, irradiated Lewis rats were restored with bone marrow from allogeneic or F1 donors. They were passively sensitized to tuberculin by a subsequent transfer of Lewis lymph node cells and were given intradermal skin tests with tuberculoprotein. In 24 hr reactions the majority of cells were shown to be derived from the infused marrow. These results were the same regardless whether the lymphocyte transfer was performed on the day of irradiation and marrow injection or 7 days later. The cells in the tuberculin reactions, marrow, spleen, and lymph nodes not derived from the bone marrow were found to originate in the transferred lymph node cells. The relative percentages of marrow-derived and lymph node-derived cells in the tuberculin reactions remained the same during the 9–24 hr period following skin test.

ABILITY OF BONE MARROW CELLS AND LYMPH NODE CELLS TO INDUCE TOLERANCE OF SKIN IN MHC-CONGENIC RATS

1993 ◽  
Vol 56 (4) ◽  
pp. 962-963
Author(s):  
LISE DESQUENNE-CLARK ◽  
HIROMITSU KIMURA ◽  
WILLYS K. SILVERS
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Bone Marrow Cells ◽  
Lymph Node Cells ◽  
Marrow Cells
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