scholarly journals Value of Nuchal Translucency in Detection of Chromosomal Aberration in Vietnam Population

2021 ◽  
pp. 1-5
Author(s):  
Long Hai Nguyen ◽  
Keyword(s):  
Sensitivity And Specificity ◽  
Trisomy 21 ◽  
Sex Chromosome ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Diagnostic Anténatal ◽  
Trimester Screening ◽  
Chromosomal Defects ◽  
Singleton Pregnancies

Objective: To examine the sensitivity and specificity of different thresholds of nuchal translucency in diagnosis of chromosomal defects. Study Design: This is a longitudinal study of pregnant women have first trimester screening and ultrasound in center of diagnostic antenatal of national hospital of obstetrics and gynecology. A follow-up was made to identify, in all singleton pregnancies in both group of which fetal karyotyping was made and group of normal fetuses. The threshold for nuchal translucency was divided in to above the 95th percentile, the 99th percentile, the 3.0mm and 2.5 MoM of nuchal translucency. The sensitivity and specificity ware calculated in order to diagnosis the chromosomal abbreviation. Results: The research identified 2645 fetuses, 743 amniocentesis (28%). There is 32.4% fetus has NT ≥ the 95th percentile, 28.6% ≥ 2.5mm percentile, 22.3% ≥ 3.0mm, 16.6% above 2.5 MoM. The fetal karyotype was abnormal in 157 (5.8%) pregnancies. The popular conditions were found including trisomy 21(52.2%). Then structural rearrangements occupied 31.2%. Other chromosomes like 13,18,21 occupied 12.7%. The abnormal of sex chromosome was smallest proportion with only 3.8%. At the 95th percentile of nuchal translucency has the highest sensitivity in detection of chromosomal defects (99.4%) but the threshold 2.5mm has a better detection rate (20.4%). The cut off 3.0mm has a better positive prediction rate (22.3%) but could detect less defects (only 132/157 abbreviation). The threshold 2.5xMoM had the highest specificity (86.4%) but lowest sensitivity (only 65%). Conclusion: In fetuses with increased nuchal translucency, more than a half of the chromosomally abnormal group is affected by defects other than trisomy 21 (52.2%). Using threshold 2.5mm helps detect more 23 chromosomal defects in comparison with the threshold 3.0mm and it had the highest average of sensitivity and specificity (87.25%).

722: Follow-up frequency of testing in patients at very low risk for Trisomy 21 on first trimester screening

2012 ◽  
Vol 206 (1) ◽  
pp. S321
Author(s):  
Alireza A. Shamshirsaz ◽  
Samadh Ravangard ◽  
Amirhoushang A. Shamshirsaz ◽  
James Egan ◽  
Winston A. Campbell ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
Low Risk ◽  
First Trimester Screening ◽  
Trimester Screening

CHROMOSOMAL DEFECTS IN INCREASED NUCHAL TRANSLUCENCY FETUS

2021 ◽  
Vol 62 (6) ◽  
Author(s):  
Nguyen Hai Long ◽  
Tran Danh Cuong ◽  
Ngo Toan Anh ◽  
Le Pham Sy Cuong ◽  
Nguyen Thi Thu Huong ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Trisomy 21 ◽  
Maternal Age ◽  
Nuchal Translucency ◽  
Trisomy 13 ◽  
Crown Rump Length ◽  
Chromosomal Defects ◽  
Singleton Pregnancies ◽  
Increased Nuchal Translucency

Objectives: Determination of the prevalence of all chromosomal defects and its distribution in fetuses with increased nuchal translucency thickness. Methodology: This is a retrospective study among pregnant women indicated for amniocentesis by nuchal translucency above 2.5 mm and consent to the study. 2720 cases were included to the study during 6 years’ period from 2015 to 2020. All singleton pregnancies whose nuchal transluciency measurements were equal or over 2.5mm, were indicated for amniocentesis. Results: The study was consist of 2720 amniocentesis in which fetal nuchal transluciency was elevated. The median maternal age was 29.19 years old (range 17-46), and the median fetal crown-rump length was 66.9 mm (range 45– 84). The fetal karyotype was abnormal in 560 (20.6%) pregnancies. The popular chromosomal conditions were including trisomy 21(55%), trisomy 18 (11.2%), trisomy 13 (3.9%), 45, XO (2.7%). Chromosomal aberrations rate was 17.6% at maternal age of 30- 34, 34% and 50.0% at maternal age of 35- 39 and ≥ 40 respectively. Conclusion: In fetuses with increased nuchal translucency, more than a half of the chromosomal aberrations were trisomy 21 (55.0%). Structural rearrangements were 22.5%. Advanced maternal age (above 35) increases the risk of chromosomal aberrations.

scholarly journals P10.03: First trimester screening of trisomy 21 by nuchal translucency measurement

2004 ◽  
Vol 24 (3) ◽  
pp. 321-321
Author(s):  
R. Has ◽  
I. Kalelioglu ◽  
H. Ermis ◽  
L. Ibrahimoglu ◽  
A. Yuksel ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
Nuchal Translucency ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Nuchal Translucency Measurement

Evaluation of Normal Heart Rate in Early Pregnancy Corresponding to Gestational Age between Six to Eight Weeks

Med Phoenix ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 34-37
Author(s):  
Akhilesh Kumar Jha ◽  
Bikranta Rimal ◽  
Tarannum Khatun
Keyword(s):  
Heart Rate ◽  
Early Pregnancy ◽  
Well Being ◽  
Clinical Decision ◽  
First Trimester ◽  
Normal Heart ◽  
Normal Heart Rate ◽  
First Trimester Of Pregnancy ◽  
Singleton Pregnancies

Background: Ultrasonography is the reliable and safe way for the evaluation of pregnancy. Heart rate can be detected more confidently from the Ultrasonography. Heart rate is an important parameter for the evaluation of early pregnancy. The purpose of this study was to evaluate the normal heart rate in embryos/fetuses between 6 and 8 weeks of gestation.Method: In our region people are poor and most of them do not know the benefit of regular follow up examination during pregnancy. So most of pregnant women come to our centre at late stage of pregnancy. The number of pregnancy cases is good in our centre but the number of early pregnancy cases coming to regular follow up examination is low. Thus the study was conducted in 51 normal singleton pregnancies undergoing routine ultrasound examination during the first trimester of pregnancy. The duration of study was 6 weeks.Result: Out of 51 singleton pregnancies, 20 cases (39.2%) heart rate were between 131-150 beat per minute and 25 cases (49.0 %) heart rate were between 151-170 beat per minute. However 4 cases (7.8%) were between 110-120 beat per minute and 2 cases (3.9%) were more than 171 beat per minute. There were zero cases above the 180 beat per minute.Conclusion: The result of this study will help to evaluate abnormal and normal fetal heart rate so that early clinical decision whether to continue the pregnancy or terminate it can be taken, as Ultrasonography is only the method used in screening fetal well being in most of the region of our country.Med Phoenix Vol.2(1) July 2017, 34-37

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