scholarly journals Morphological features of tumor in different treatment options for patients With Locally Advanced Breast Cancer

2020 ◽  
Vol 1 (7) ◽  
pp. 105-107
Author(s):  
Narzieyva D.F ◽  
Jonibekov J.J ◽  
Erkinova Sh.N
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Treatment Options ◽  
Molecular Genetic ◽  
Locally Advanced ◽  
Morphological Structure ◽  
Advanced Breast ◽  
Ki 67 ◽  
The Republic

Despite significant advances in the early diagnosis and treatment of locally advanced breast cancer, 60–65% of the Republic of Uzbekistan is accounted for by locally advanced breast cancer and its mortality rate is high. The morphological structure of breast cancer is important for the prognosis of the disease. On cell membranes there are special cytoplasmic proteins - receptors, which, when combined with hormones, can affect the rate of division of tumor cells. In terms of the choice of treatment options and the assessment of the forecast, some molecular genetic parameters of the tumor are important, among which, first of all, the hormonal status of the tumor (ER / PR), HER-2 / neu, p53, Bcl-2, Ki-67

scholarly journals Ki-67 expression predicts clinical outcome in locally advanced breast cancer

The Breast ◽  
2011 ◽  
Vol 20 ◽  
pp. S25-S26
Author(s):  
Naomi Kobayashi ◽  
Masahiro Hikichi ◽  
Shinsuke Miyajima ◽  
Kaori Ushimado ◽  
Toshiaki Utsumi
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Ki 67

scholarly journals Capabilities of Magnetic Resonance Volumetry in Assessing the Response to Neoadjuvant Therapy of Primary Operable and Locally Advanced Breast Cancer

2021 ◽  
pp. 12-23
Author(s):  
M. V. Egorov
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance ◽  
Advanced Breast Cancer ◽  
Neoadjuvant Therapy ◽  
Steroid Receptors ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Ki 67 ◽  
Degree Of Malignancy

The aim of the work was to analyze the significance of magnetic resonance volumetric measurement in assessing the response to neoadjuvant therapy for primary operable and locally advanced breast cancer (BC). The study included 77 patients aged 30 to 80 years, of which 40 (67,5 %) patients were with primary resectable and 37 (32,5 %) with locally advanced primary non-resectable ВС. When planning neoadjuvant therapy (NAT), the determining factors were the degree of malignancy (G) and proliferative activity (Ki-67) of the tumor, the level of expression of steroid receptors (estrogen — ER / progesterone — PR) and the HER2/neu protein. Completed from 4 to 6 courses of NAT. Their effectiveness was analyzed according to the data of multiparametric magnetic resonance imaging (mpMRI); changes in the tumor volume and its axial dimensions were taken into account. When comparing the sizes of tumors determined by the results of the analysis of the resection material and MRI, it was found that MR-volumetry has a higher sensitivity (Ac = 89,6; 95 % CI: 64,1–90,9) compared to the RECIST 1.1 criteria, taking into account the linear dimensions (Ac = 78,3; 95 % CI: 53,6–93,0).

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