Peripheral Giant Cell Reparative Granuloma of the Sino-orbital Region—A Giant Lesion: A Rare Case Report

ABSTRACT Peripheral giant cell reparative granulomas (PGCRGs) are benign tumors which spread locally and progress aggressively. The origin of the multinucleated giant cells is not established till date, and hence various theories suggesting the origin from osteoclasts based on the immunohistochemical features, or from mononuclear phagocyte system. The treatment of choice is surgical excision with adequate margins and the recurrence rates are usually below 10% as per the reported literature.1 We present a 6-year-old child who presented with a rapidly progressive sino-orbital mass leading to proptosis and lateral displacement of the right globe. He underwent combined approach (open and endoscopic assisted) for complete excision of the lesion. The histopathological features were consistent with PGCRG. This case is being highlighted with the aim of developing insights about the clinical presentation and management of PGCRG. How to cite this article John M, Ashish G, Prabhu AJ, Mani S, Kurien M. Peripheral Giant Cell Reparative Granuloma of the Sino-orbital Region—A Giant Lesion: A Rare Case Report. Int J Otorhinolaryngol Clin 2014;6(3):109-113.