Chapter-057 Anterior Corneal Dystrophies: Dystrophies of the Epithelium, Epithelial Basement Membrane and Bowmanӳ Layer

Author(s):  
Copeland Robert
1987 ◽  
Vol 24 (1) ◽  
pp. 28-33 ◽  
Author(s):  
C. P. Moore ◽  
R. Dubielzig ◽  
S. M. Glaza

Spontaneously occurring anterior corneal opacities were present in related, juvenile American Dutch belted rabbits. Slit lamp biomicroscopy revealed focal opacities of epithelium, basement membrane, and subepithelial corneal stroma. Lesions were characterized histologically by thin and disorganized surface epithelium, thickened and intensely staining epithelial basement membrane, fimbriated and irregular basement membrane-stromal juncture, and disorganized subepithelial stroma. Biomicroscopic and histopathologic features of anterior corneal dystrophy of American Dutch belted rabbits appear similar to those of human anterior corneal dystrophies.


Cornea ◽  
2008 ◽  
Vol 27 (3) ◽  
pp. 374-377 ◽  
Author(s):  
Federico A Cremona ◽  
Faris R Ghosheh ◽  
Peter R Laibson ◽  
Christopher J Rapuano ◽  
Elisabeth J Cohen

Author(s):  
Douglas R. Keene ◽  
Gregory P. Lunstrum ◽  
Patricia Rousselle ◽  
Robert E. Burgeson

A mouse monoclonal antibody produced from collagenase digests of human amnion was used by LM and TEM to study the distribution and ultrastructural features of an antigen present in epithelial tissues and in cultured human keratinocytes, and by immunoaffinity chromatography to partially purify the antigen from keratinocyte cell culture media.By immunofluorescence microscopy, the antigen displays a tissue distribution similar to type VII collagen; positive staining of the epithelial basement membrane is seen in skin, oral mucosa, trachea, esophagus, cornea, amnion and lung. Images from rotary shadowed preparations isolated by affinity chromatography demonstrate a population of rod-like molecules 107 nm in length, having pronounced globular domains at each end. Polyacrylamide gel electrophoresis suggests that the size of this molecule is approximately 440kDa, and that it is composed of three nonidentical chains disulfide bonded together.


1994 ◽  
Vol 8 (1) ◽  
pp. 26 ◽  
Author(s):  
Dong H. Shin ◽  
Shlomo S. Mandel ◽  
Jin H. Lee ◽  
Brett Ernst ◽  
Bruce L. Newman ◽  
...  

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Xue Liu ◽  
Yinshan Fang ◽  
Paul W. Noble ◽  
Jianwen Que ◽  
Dianhua Jiang

1990 ◽  
Vol 27 (1) ◽  
pp. 14-23
Author(s):  
Shinobu Matsuo ◽  
Neal S. Penneys ◽  
Jo-David Fine ◽  
Steffen Gay ◽  
Mehrdad Nadji

Sign in / Sign up

Export Citation Format

Share Document