scholarly journals A comprehensive investigation on liver regeneration: a meta-analysis and systems biology approach

2021 ◽  
Vol 7 (2) ◽  
pp. 183-190
Author(s):  
Solmaz Asnaashari ◽  
Elham Amjad ◽  
Babak Sokouti
Keyword(s):  
Systems Biology ◽  
Liver Regeneration ◽  
Meta Analysis ◽  
Comprehensive Investigation

scholarly journals Cloud‐based archived metabolomics data: A resource for in‐source fragmentation/annotation, meta‐analysis and systems biology

2020 ◽  
Author(s):  
Amelia Palermo ◽  
Tao Huan ◽  
Duane Rinehart ◽  
Markus M. Rinschen ◽  
Shuzhao Li ◽  
...  
Keyword(s):  
Systems Biology ◽  
Meta Analysis ◽  
Metabolomics Data

scholarly journals The effect of preoperative chemotherapy on liver regeneration after portal vein embolization/ligation or liver resection in patients with colorectal liver metastasis: a systematic review protocol

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Mihai-Calin Pavel ◽  
Raquel Casanova ◽  
Laia Estalella ◽  
Robert Memba ◽  
Erik Llàcer-Millán ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Liver Resection ◽  
Liver Metastasis ◽  
Neoadjuvant Chemotherapy ◽  
Portal Vein ◽  
Liver Failure ◽  
Liver Regeneration ◽  
Meta Analysis ◽  
Number Of Cycles

Abstract Introduction Liver resection (LR) in patients with liver metastasis from colorectal cancer remains the only curative treatment. Perioperative chemotherapy improves prognosis of these patients. However, there are concerns regarding the effect of preoperative chemotherapy on liver regeneration, which is a key event in avoiding liver failure after LR. The primary objective of this systematic review is to assess the effect of neoadjuvant chemotherapy on liver regeneration after (LR) or portal vein embolization (PVE) in patients with liver metastasis from colorectal cancer. The secondary objectives are to evaluate the impact of the type of chemotherapy, number of cycles, and time between end of treatment and procedure (LR or PVE) and to investigate whether there is an association between degree of hypertrophy and postoperative liver failure. Methods This meta-analysis will include studies reporting liver regeneration rates in patients submitted to LR or PVE. Pubmed, Scopus, Web of Science, Embase, and Cochrane databases will be searched. Only studies comparing neoadjuvant vs no chemotherapy, or comparing chemotherapy characteristics (bevacizumab administration, number of cycles, and time from finishing chemotherapy until intervention), will be included. We will select studies from 1990 to present. Two researchers will individually screen the identified records, according to a list of inclusion and exclusion criteria. Primary outcome will be future liver remnant regeneration rate. Bias of the studies will be evaluated with the ROBINS-I tool, and quality of evidence for all outcomes will be determined with the GRADE system. The data will be registered in a predesigned database. If selected studies are sufficiently homogeneous, we will perform a meta-analysis of reported results. In the event of a substantial heterogeneity, a qualitative systematic review will be performed. Discussion The results of this systematic review may help to better identify the patients affected by liver metastasis that could present low regeneration rates after neoadjuvant chemotherapy. These patients are at risk to develop liver failure after extended hepatectomies and therefore are not good candidates for such aggressive procedures. Systematic review registration PROSPERO registration number: CRD42020178481 (July 5, 2020).

scholarly journals Prevalence of foramen arcuale and its clinical significance: a meta-analysis of 55,985 subjects

2017 ◽  
Vol 27 (3) ◽  
pp. 276-290 ◽  
Author(s):  
Przemysław A. Pękala ◽  
Brandon M. Henry ◽  
Jakub R. Pękala ◽  
Wan Chin Hsieh ◽  
Jens Vikse ◽  
...  
Keyword(s):  
Vertebral Artery ◽  
Ethnic Group ◽  
Gold Standard ◽  
Meta Analysis ◽  
Posterior Arch ◽  
Preoperative Screening ◽  
Comprehensive Investigation ◽  
Anatomical Features ◽  
North Americans ◽  
Pooled Prevalence

OBJECTIVEThe foramen arcuale (FA) is a bony bridge located over the vertebral artery on the posterior arch of the atlas. The presence of an FA can pose a risk during neurosurgery by providing a false impression of a broader posterior arch. The aim of this study was to provide the most comprehensive investigation on the prevalence of the FA and its clinically important anatomical features.METHODSMajor electronic databases were searched to identify all studies that reported relevant data on the FA and the data were pooled into a meta-analysis.RESULTSA total of 127 studies (involving 55,985 subjects) were included. The overall pooled prevalence of a complete FA was 9.1% (95% CI 8.2%–10.1%) versus an incomplete FA, which was 13.6% (95% CI 11.2%–16.2%). The complete FA was found to be most prevalent in North Americans (11.3%) and Europeans (11.2%), and least prevalent among Asians (7.5%). In males (10.4%) the complete FA was more common than in females (7.3%) but an incomplete FA was more commonly seen in females (18.5%) than in males (16.7%). In the presence of a complete FA, a contralateral FA (complete or incomplete) was found in 53.1% of cases.CONCLUSIONSSurgeons should consider the risk for the presence of an FA prior to procedures on the atlas in each patient according to sex and ethnic group. We suggest preoperative screening with computerized tomography as the gold standard for detecting the presence of an FA.

scholarly journals The basis of liver regeneration: A systems biology approach

2019 ◽  
Vol 18 (3) ◽  
pp. 422-428 ◽  
Author(s):  
Mamatha Bhat ◽  
Elisa Pasini ◽  
Cristina Baciu ◽  
Marc Angeli ◽  
Atul Humar ◽  
...  
Keyword(s):  
Systems Biology ◽  
Liver Regeneration

scholarly journals The effect of preoperative chemotherapy on liver regeneration after portal vein embolization/ligation or liver resection in patients with colorectal liver metastasis: a systematic review protocol

2020 ◽  
Author(s):  
Mihai-Calin Pavel ◽  
Raquel Casanova ◽  
Laia Estalella ◽  
Robert Memba ◽  
Erik Llàcer-Millán ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Liver Resection ◽  
Liver Metastasis ◽  
Neoadjuvant Chemotherapy ◽  
Portal Vein ◽  
Liver Failure ◽  
Liver Regeneration ◽  
Meta Analysis ◽  
Number Of Cycles

Abstract Introduction: Liver resection (LR) in patients with liver metastasis from colo-rectal cancer remains the only curative treatment. Perioperative chemotherapy improves prognosis of these patients. However, there are concerns regarding the effect of preoperative chemotherapy on liver regeneration, which is a key event in avoiding liver failure after LR. The primary objective of this systematic review is to assess the effect of neoadjuvant chemotherapy on liver regeneration after (LR) or portal vein embolization (PVE) in patients with liver metastasis from colo-rectal cancer. The secondary objectives are to evaluate the impact of the type of chemotherapy, number of cycles and time between end of treatment and procedure (LR or PVE) and to investigate whether there is an association between degree of hypertrophy and postoperative liver failure.Methods: This meta-analysis will include studies reporting liver regeneration rates in patients submitted to LR or PVE. Pubmed, Scopus, Web of Science, Embase and Cochrane databases will be searched. Only studies comparing neoadjuvant vs no chemotherapy, or comparing chemotherapy characteristics (bevacizumab administration, number of cycles and time from finishing chemotherapy until intervention) will be included. We will select studies from 1990 to present. Two researchers will individually screen the identified records, according to a list of inclusion and exclusion criteria. Primary outcome will be future liver remnant regeneration rate. Bias of the studies will be evaluated with the ROBINS-I tool and quality of evidence for all outcomes will be determined with the GRADE system. The data will be registered in a predesigned database. If selected studies are sufficiently homogeneous, we will perform a meta-analysis of reported results. In the event of a substantial heterogeneity, a qualitive systematic review will be performed.Discussion: The results of this systematic review may help to better identify the patients affected by liver metastasis that could present low regeneration rates after neoadjuvant chemotherapy. These patients are at risk to develop liver failure after extended hepatectomies and therefore are not good candidates for such aggressive procedures.Systematic Review Registration: PROSPERO registration number: CRD42020178481 (July 5th 2020).

scholarly journals Identifying novel glioma associated pathways based on systems biology level meta-analysis

2013 ◽  
Vol 7 (Suppl 2) ◽  
pp. S9 ◽  
Author(s):  
Yangfan Hu ◽  
Jinquan Li ◽  
Wenying Yan ◽  
Jiajia Chen ◽  
Yin Li ◽  
...  
Keyword(s):  
Systems Biology ◽  
Meta Analysis
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