scholarly journals An Implementation, Empirical Evaluation and Proposed Improvement for Bidirectional Splitting Method for Argumentation Framework Under Stable Semantics

Author(s):  
Renata Wong
1986 ◽  
Vol 47 (7) ◽  
pp. 1149-1154
Author(s):  
Le Quang Rang ◽  
D. Voslamber

Author(s):  
Nico Potyka

Bipolar abstract argumentation frameworks allow modeling decision problems by defining pro and contra arguments and their relationships. In some popular bipolar frameworks, there is an inherent tendency to favor either attack or support relationships. However, for some applications, it seems sensible to treat attack and support equally. Roughly speaking, turning an attack edge into a support edge, should just invert its meaning. We look at a recently introduced bipolar argumentation semantics and two novel alternatives and discuss their semantical and computational properties. Interestingly, the two novel semantics correspond to stable semantics if no support relations are present and maintain the computational complexity of stable semantics in general bipolar frameworks.


2018 ◽  
Author(s):  
Timothy Newhouse ◽  
Daria E. Kim ◽  
Joshua E. Zweig

The diverse molecular architectures of terpene natural products are assembled by exquisite enzyme-catalyzed reactions. Successful recapitulation of these transformations using chemical synthesis is hard to predict from first principles and therefore challenging to execute. A means of evaluating the feasibility of such chemical reactions would greatly enable the development of concise syntheses of complex small molecules. Herein, we report the computational analysis of the energetic favorability of a key bio-inspired transformation, which we use to inform our synthetic strategy. This approach was applied to synthesize two constituents of the historically challenging indole diterpenoid class, resulting in a concise route to (–)-paspaline A in 9 steps from commercially available materials and the first pathway to and structural confirmation of emindole PB in 13 steps. This work highlights how traditional retrosynthetic design can be augmented with quantum chemical calculations to reveal energetically feasible synthetic disconnections, minimizing time-consuming and expensive empirical evaluation.


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