scholarly journals ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER

2021 ◽  
Vol 71 (5) ◽  
pp. 1875-79
Author(s):  
Aisha Shahid ◽  
Ghulam Haider ◽  
Paras Memon ◽  
Shumyla Beg ◽  
Mehwish Shahzadi ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Endometrial Carcinoma ◽  
Menopausal Status ◽  
Stage Iv ◽  
Receptor Expression ◽  
Low Grade ◽  
Endometrioid Adenocarcinoma ◽  
Histological Findings ◽  
Estrogen And Progesterone Receptor

Objective: To determine the association of estrogen and progesterone receptor expression with the clinical and histological findings of endometrial cancer. Study Design: Prospective observational study. Place and Duration of Study: Jinnah Postgraduate Medical Centre, Karachi between Sep 2017 to Oct 2019. Methodology: A total of 130 patients were diagnosed with endometrial carcinoma. Data from patient files were collected regarding tumour histology, grade, stage, tumour receptor expression, and the clinical characteristics: parity, menopausal status. The receptor expression profile was documented for each patient. Data were analyzed using SPSS version 25. The association between ER/PR expression categories and clinical/histological features were explored using the chi-square test. Results: The estrogen and progesterone receptor expressions were significantly associated with low-grade (Grade I and II) tumours and with Stage I and Stage II endometrial carcinoma with p<0.001. About 34 (34.7%) cases of endometrioid histology were negative for both estrogen and progesterone receptors. The ER and PR negativity was strongly associated with Grade III endometrial cancer (p=0.003). The majority of the stage IV cancers were negative for both the ER and PR receptors with a p<0.001. Conclusion: Estrogen and progesterone positivity was associated with endometrioid adenocarcinoma, well-differentiated, and less advanced stage of endometrial cancer at the time of diagnosis.

147 Association of Estrogen Receptor and Porgesteron Receptor Positivity with Nodal Involvement, Menopause Status and Stage of Primary Invasive Carcinoma of Breast Among Patients Presenting to Fauji Foundation Hospital, Islamabad

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
D Bhatti
Keyword(s):  
Progesterone Receptor ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Menopausal Status ◽  
Stage Iv ◽  
Receptor Expression ◽  
Nodal Involvement ◽  
Carcinoma Breast ◽  
Node Positive ◽  
Estrogen And Progesterone Receptor

Abstract Aim To determine the percentage of estrogen and progesterone receptor positivity along with histological variants, stage, and menopausal status among carcinoma breast patients in our setup. Method This was a retrospective observational study. Data from records of patients with breast carcinoma presenting at Oncology Department Fauji Foundation Hospital, Islamabad was evaluated. H+E stained slides from 431 cases with carcinoma breast, patients over the age of 18 years, were reviewed and the presence of invasive carcinoma was confirmed in all cases. Patients with metastases were excluded. Paraffin blocks were assessed immunohistochemically for estrogen and progesterone receptor expression. Histological subtypes, stages of tumors, and nodal involvement were also noted. Data were analyzed using SPSS. Results Records of 431 patients were evaluated. The median age was 53 years. The most common histological variant was invasive ductal carcinoma. 4.6% of patients had stage I, 33.4% had stage II, 40% had Stage III and 22% had Stage IV disease. Overall, 62% had node-positive disease. Overall ER+, PR+, ER+/PR+, ER+/PR-, ER-/PR+ and ER-/PR- percentages were 52%, 54%, 42%, 11%, 12% and 35% respectively. 38% of patients were premenopausal, 59% were postmenopausal and 3% were perimenopausal. Patients with node positive diseases were 51% ER+,55% PR+, 43% ER+/PR+, 8% ER+/PR-, 12% ER-/PR+ and 37% ER-/PR-. Conclusions The percentage of ER/PR+ is the highest in our study. Pre-menopausal patients showed approximately equal positivity to post-menopausal patients. Node positive enrolments had increased positivity of ER/PR receptor.

Can the apparent diffusion coefficient differentiate the grade of endometrioid adenocarcinoma and the histological subtype of endometrial cancer?

2017 ◽  
Vol 59 (3) ◽  
pp. 363-370 ◽  
Author(s):  
Bin Yan ◽  
Tingting Zhao ◽  
Xiufen Liang ◽  
Chen Niu ◽  
Caixia Ding
Keyword(s):  
Diffusion Coefficient ◽  
Endometrial Cancer ◽  
Apparent Diffusion Coefficient ◽  
Low Grade ◽  
Endometrioid Adenocarcinoma ◽  
High Grade ◽  
Squamous Differentiation ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Endometrial Cancers

Background Diffusion-weighted imaging (DWI) provides useful information for the identification of benign and malignant uterine lesions. However, the use of the apparent diffusion coefficient (ADC) for histopathological grading of endometrial cancer is controversial. Purpose To explore the use of ADC values in differentiating the preoperative tumor grading of endometrioid adenocarcinomas and investigate the relationship between the ADC values of endometrial cancer and the histological tumor subtype. Material and Methods We retrospectively evaluated 98 patients with endometrial cancers, including both endometrioid adenocarcinomas (n = 80) and non-endometrioid adenocarcinomas (n = 18). All patients underwent DWI procedures and ADC values were calculated. The Kruskal–Wallis test and the independent samples Mann–Whitney U test were used to compare differences in the ADC values between different tumor grades and different histological subtypes. Results The mean ADC values (ADCmean) for high-grade endometrioid adenocarcinomas were significantly lower than the values for low-grade tumors (0.800 versus 0.962 × 10–3 mm2/s) ( P = 0.002). However, no significant differences in ADCmean and minimum ADC values (ADCmin) were found between tumor grades (G1, G2, and G3) of endometrial cancer. Compared with endometrioid adenocarcinomas, the adenocarcinoma with squamous differentiation showed lower ADC values (mean/minimum = 0.863/0.636 versus 0.962/0.689 × 10–3 mm2/s), but the differences were not significant ( Pmean = 0.074, Pmin = 0.441). Moreover, ADCmean for carcinosarcomas was significantly higher than the value for G3 non-carcinosarcoma endometrial cancers (1.047 versus 0.823 × 10–3 mm2/s) ( P = 0.001). Conclusion The ADCmean was useful for identifying high-grade and low-grade endometrioid adenocarcinomas. Additionally, squamous differentiation may decrease ADCmean and ADCmin of endometrioid adenocarcinoma, and carcinosarcomas showed relatively high ADCmean.

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