scholarly journals Surfactant protein B deficiency: a rare cause of respiratory failure in a Lebanese newborn

2006 ◽  
Vol 26 (1) ◽  
pp. 69-70
Author(s):  
George Ferzli ◽  
Khalid A. Yunis ◽  
Salman Mroueh
Keyword(s):  
Respiratory Failure ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Protein B

Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure

2006 ◽  
Vol 149 (4) ◽  
pp. 548-553 ◽  
Author(s):  
Lisanne M. Palomar ◽  
Lawrence M. Nogee ◽  
Stuart C. Sweet ◽  
Charles B. Huddleston ◽  
F. Sessions Cole ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Lung Transplantation ◽  
Surfactant Protein ◽  
Long Term Outcomes ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Protein B

Transient surfactant protein B deficiency in a term infant with severe respiratory failure

1998 ◽  
Vol 132 (2) ◽  
pp. 244-248 ◽  
Author(s):  
Jonathan M. Klein ◽  
Mark W. Thompson ◽  
Jeanne M. Snyder ◽  
Thomas N. George ◽  
Jeffrey A. Whitsett ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Surfactant Protein ◽  
Term Infant ◽  
Severe Respiratory Failure ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Protein B

Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia*

2004 ◽  
Vol 32 (5) ◽  
pp. 1115-1119 ◽  
Author(s):  
Michael W. Quasney ◽  
Grant W. Waterer ◽  
Mary K. Dahmer ◽  
Grace K. Kron ◽  
Qing Zhang ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Surfactant Protein ◽  
Community Acquired Pneumonia ◽  
Surfactant Protein B ◽  
Protein B

scholarly journals Surfactant Phosphatidylcholine Metabolism in Patients with Congenital Surfactant Protein-B Deficiency Studied with Stable Isotopes

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 306A-306A
Author(s):  
Daphne J M T Janssen ◽  
Virgilio P Carnielli ◽  
Jan Erik H Bunt ◽  
Ingrid H T Luijendijk ◽  
Dick Tibboel ◽  
...  
Keyword(s):  
Stable Isotopes ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Phosphatidylcholine Metabolism ◽  
Protein B

Hereditary surfactant protein B deficiency resulting from a novel mutation

2000 ◽  
Vol 26 (1) ◽  
pp. 97-100 ◽  
Author(s):  
M. Somaschini ◽  
S. Wert ◽  
G. Mangili ◽  
A. Colombo ◽  
L. Nogee
Keyword(s):  
Novel Mutation ◽  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Protein B

Congenital surfactant protein B deficiency - emphasis on imaging

2001 ◽  
Vol 31 (5) ◽  
pp. 327-331 ◽  
Author(s):  
B. Newman ◽  
Jerald P. Kuhn ◽  
Sandra S. Kramer ◽  
Joseph A. Carcillo
Keyword(s):  
Surfactant Protein ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Protein B

Association of the 1580 (C/T) Polymorphism in the Surfactant Protein B Gene with the Severity of Respiratory Failure after Allogeneic Transplantation.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 1840-1840
Author(s):  
Thomas Illmer ◽  
Catrin Theuser ◽  
Christian Thiede ◽  
Markus Schaich ◽  
Simone Trautmann ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Allogeneic Transplantation ◽  
Surfactant Protein ◽  
Efficient Treatment ◽  
Non Invasive ◽  
Surfactant Protein B ◽  
Non Invasive Ventilation ◽  
To Receive ◽  
Protein B

Abstract Respiratory failure is a serious early complication confounding the clinical effect of allogeneic stem cell transplantation and early detection may be crucial for efficient treatment. We introduced a system of intensive oxigenation monitoring in patients transplanted in our center between November 2001 and December 2003. All allogeneic transplanted patients were followed by a twice daily measurement of oxi-index (paO2/FiO2) during the transplantation period (untill day + 25). Patients that fulfilled criteria of acute lung injury (oxi-index <300) were treated by O2 application vs. non-invasive ventilation (NIV). Failure to increase oxi-index above the threshold of 300 led to referral of the patient to ICU were intensified NIV was applied and/or mechanical ventilation (MV) was initiated based on a defined scoring system. 165 patients were followed for the development of ALI. 48 (29.1%) developed oxiindices <300 (ALI). Development of ALI predicted for a significantly higher rate of ICU admissions (37.5% vs. 6.8% in non-ALI patients; p<0.001) and MV (20.8 % vs. 1.7 in non-ALI patients; p<0.001). ALI was most commonly diagnosed during the engraftment period but was at diagnosis not associated with other criteria like respiration rate, CRP and tachycardia. Since members of the pulmonary innate immune system may be associated with the development of ALI and ARDS we screened the 165 patients for the presence of alternative alleles in the Surfactant Protein B (SP-B) gene. A polymorphism at position +1580 (T/C variation) of SP-B has been previously found to be associated with the development of ARDS. Polymorphism of SP-B were not associated with the development of ALI and did not predict for the need of intensified ICU treatment. However, the rate of MV varied considerably. Nine patients with the T/T genotype (9 out of 42, 21.4%) required intubation and mechanical ventilation whereas none of the patients with C/C had to receive MV (0 out of 30; p=0.01).The data indicate that measurement of the oxiindex is an early sensitive parameter of respiratory failure in allogeneic transplantation and that severity of respiratory damage may be predicted by the T allele at the SP-B +1580 site

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