Association of the 1580 (C/T) Polymorphism in the Surfactant Protein B Gene with the Severity of Respiratory Failure after Allogeneic Transplantation.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 1840-1840
Author(s):  
Thomas Illmer ◽  
Catrin Theuser ◽  
Christian Thiede ◽  
Markus Schaich ◽  
Simone Trautmann ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Allogeneic Transplantation ◽  
Surfactant Protein ◽  
Efficient Treatment ◽  
Non Invasive ◽  
Surfactant Protein B ◽  
Non Invasive Ventilation ◽  
To Receive ◽  
Protein B

Abstract Respiratory failure is a serious early complication confounding the clinical effect of allogeneic stem cell transplantation and early detection may be crucial for efficient treatment. We introduced a system of intensive oxigenation monitoring in patients transplanted in our center between November 2001 and December 2003. All allogeneic transplanted patients were followed by a twice daily measurement of oxi-index (paO2/FiO2) during the transplantation period (untill day + 25). Patients that fulfilled criteria of acute lung injury (oxi-index <300) were treated by O2 application vs. non-invasive ventilation (NIV). Failure to increase oxi-index above the threshold of 300 led to referral of the patient to ICU were intensified NIV was applied and/or mechanical ventilation (MV) was initiated based on a defined scoring system. 165 patients were followed for the development of ALI. 48 (29.1%) developed oxiindices <300 (ALI). Development of ALI predicted for a significantly higher rate of ICU admissions (37.5% vs. 6.8% in non-ALI patients; p<0.001) and MV (20.8 % vs. 1.7 in non-ALI patients; p<0.001). ALI was most commonly diagnosed during the engraftment period but was at diagnosis not associated with other criteria like respiration rate, CRP and tachycardia. Since members of the pulmonary innate immune system may be associated with the development of ALI and ARDS we screened the 165 patients for the presence of alternative alleles in the Surfactant Protein B (SP-B) gene. A polymorphism at position +1580 (T/C variation) of SP-B has been previously found to be associated with the development of ARDS. Polymorphism of SP-B were not associated with the development of ALI and did not predict for the need of intensified ICU treatment. However, the rate of MV varied considerably. Nine patients with the T/T genotype (9 out of 42, 21.4%) required intubation and mechanical ventilation whereas none of the patients with C/C had to receive MV (0 out of 30; p=0.01).The data indicate that measurement of the oxiindex is an early sensitive parameter of respiratory failure in allogeneic transplantation and that severity of respiratory damage may be predicted by the T allele at the SP-B +1580 site

Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia*

2004 ◽  
Vol 32 (5) ◽  
pp. 1115-1119 ◽  
Author(s):  
Michael W. Quasney ◽  
Grant W. Waterer ◽  
Mary K. Dahmer ◽  
Grace K. Kron ◽  
Qing Zhang ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Surfactant Protein ◽  
Community Acquired Pneumonia ◽  
Surfactant Protein B ◽  
Protein B

scholarly journals Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.

1995 ◽  
Vol 92 (17) ◽  
pp. 7794-7798 ◽  
Author(s):  
J. C. Clark ◽  
S. E. Wert ◽  
C. J. Bachurski ◽  
M. T. Stahlman ◽  
B. R. Stripp ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Surfactant Protein ◽  
Targeted Disruption ◽  
Newborn Mice ◽  
Surfactant Protein B ◽  
Protein B

Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure

2006 ◽  
Vol 149 (4) ◽  
pp. 548-553 ◽  
Author(s):  
Lisanne M. Palomar ◽  
Lawrence M. Nogee ◽  
Stuart C. Sweet ◽  
Charles B. Huddleston ◽  
F. Sessions Cole ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Lung Transplantation ◽  
Surfactant Protein ◽  
Long Term Outcomes ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Protein B

Mechanical Ventilation: Advanced Ventilation and Adjuncts

2018 ◽  
Author(s):  
Adrian A. Maung ◽  
Lewis J Kaplan
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
High Frequency Oscillation ◽  
Non Invasive ◽  
Pressure Release ◽  
Non Invasive Ventilation ◽  
Ventilation Modes ◽  
Pressure Release Ventilation

In this chapter, we continue the discussion of mechanical ventilation by reviewing advanced ventilation modes such as airway pressure release ventilation and high-frequency oscillation as well as adjuncts that can be used in patients with respiratory failure. Each segment is intended to build on the preceding one and therefore establishes a functional unit with regard to mechanical ventilation, whether it is provided in an invasive or a noninvasive fashion. This review contains 6 Figures and 69 references Key Words: acute respiratory failure, airway pressure–release ventilation, acute respiratory distress syndrome, high-flow nasal cannula, mechanical ventilation, non-invasive ventilation, prone positioning

Mechanical Ventilation: Advanced Ventilation and Adjuncts

2018 ◽  
Author(s):  
Adrian A. Maung ◽  
Lewis J Kaplan
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
High Frequency Oscillation ◽  
Non Invasive ◽  
Pressure Release ◽  
Non Invasive Ventilation ◽  
Ventilation Modes ◽  
Pressure Release Ventilation

In this chapter, we continue the discussion of mechanical ventilation by reviewing advanced ventilation modes such as airway pressure release ventilation and high-frequency oscillation as well as adjuncts that can be used in patients with respiratory failure. Each segment is intended to build on the preceding one and therefore establishes a functional unit with regard to mechanical ventilation, whether it is provided in an invasive or a noninvasive fashion. This review contains 6 Figures and 69 references Key Words: acute respiratory failure, airway pressure–release ventilation, acute respiratory distress syndrome, high-flow nasal cannula, mechanical ventilation, non-invasive ventilation, prone positioning

Transient surfactant protein B deficiency in a term infant with severe respiratory failure

1998 ◽  
Vol 132 (2) ◽  
pp. 244-248 ◽  
Author(s):  
Jonathan M. Klein ◽  
Mark W. Thompson ◽  
Jeanne M. Snyder ◽  
Thomas N. George ◽  
Jeffrey A. Whitsett ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Surfactant Protein ◽  
Term Infant ◽  
Severe Respiratory Failure ◽  
Surfactant Protein B ◽  
Surfactant Protein B Deficiency ◽  
Protein B

scholarly journals Non-Invasive Ventilation in COVID-19 Related Respiratory Failure

2021 ◽  
Vol 7 (3) ◽  
pp. 139
Author(s):  
Irmi Syafa'ah
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Endotracheal Tube ◽  
Patient Selection ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Airway Clearance ◽  
Non Invasive Ventilation ◽  
First Choice ◽  
Predictor Factors

Non-invasive ventilation (NIV) refers to the technique of providing mechanical ventilation that does not require definitive airway clearance using an endotracheal tube or tracheostomy. Since its early development in the 1980s, the use of NIV has become increasingly popular in the last three decades. However, its usage on COVID-19 related respiratory failure still lacked guidelines, although several recent studies have shown its benefits. Many aspects, ranging from indications or patient selection, timing to start, understanding the predictor factors of failure, and choosing suitable interfaces, are keys of success for NIV. In principle, each patient has a different condition and should be treated case by case. NIV is not an absolute solution, and intubation can still be the first choice if NIV is deemed less beneficial for the patient.

scholarly journals A Clinical Study of Role of Noninvasive Ventilation in Community Acquired Pneumonia Patients with Acute Respiratory Failure – A Prospective Observational Study from Telangana, India

2021 ◽  
Vol 10 (22) ◽  
pp. 1686-1691
Author(s):  
Pampana Eshwaramma ◽  
Gaddam Ramulu Yadav ◽  
Vankayala Veena Reddy ◽  
Tarigopula Pramod Kumar ◽  
Mandapakala Gopala Krishna Murthy ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Observational Study ◽  
Acute Respiratory Failure ◽  
Antibiotic Therapy ◽  
Prospective Observational Study ◽  
Community Acquired Pneumonia ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

BACKGROUND Community-Acquired Pneumonia (CAP) is defined as “an acute infection of the pulmonary parenchyma. The most important complication of CAP is Acute Respiratory Failure (ARF) and some of them may require Invasive Mechanical Ventilation (IMV) to manage hypoxia and hypoventilation along with appropriate antibiotic therapy. A number of studies, however, indicate that IMV is associated with high rates of serious complications and mortality in patients with ARF. For this reason Non-Invasive Ventilation (NIV) has been used for ARF of diverse aetiologies.The most important rationale for using NIV in early stages of respiratory failure is to decrease the workload on respiratory muscles and improve ventilation by applying positive airway pressure. This may help to overcome an episode of severe ARF without the need for MV. In this study we evaluated the efficacy of NIV in patients with ARF and compare the outcome of using NIV in CAP with ARF patients with and without comorbidities. METHODS This prospective observational study was done on 150 CAP patients in acute respiratory failure who received NIV. It was conducted in the Department of Respiratory Medicine in Gandhi Hospital, Secunderabad, for a period of one year and six months. A comparative analysis of the outcome of using NIV in CAP with ARF patients with and without co-morbidities was carried out. RESULTS In the current study 150 CAP patients with ARF who needed NIV, were treated initially with NIV, antibiotic therapy and other supportive measures as per the American Thoracic Society (ATS) guidelines 32. 95 (63.3 %) of 150 patients were continuously treated with NIV. Apart from these, 55 (36.7 %) patients required MV. In patients with continued NIV, 93 (98 %) recovered, remaining 2 died with sudden cardiac arrest. In patients who were gone for MV, 12 (22 %) survived. CONCLUSIONS Early intervention by NIV in CAP patients suffering from acute respiratory failure secondary to community acquired pneumonia was found to be successful in avoiding mechanical ventilation and its attendant morbidity and mortality31. Early intervention with NIV, identifying risk factors for NIV failure, addressing associated co-morbid conditions will go in a long way in effectively managing these patients by significantly minimizing the ICU and hospital stay. Patients with co-morbidities have more chances of NIV failures. Patients with co morbidities on NIV stayed significantly more number of days in the hospital than patients without co-morbidities. The current study suggests that co morbid patients require more monitoring as compared to patients without co morbidities on NIV. KEY WORDS Community-Acquired Pneumonia (CAP), Non-Invasive Ventilation (NIV), Mechanical Ventilation (MV), Acute Respiratory Failure (ARF), Arterial Blood Gas Analysis (ABG), Intensive Care Unit (ICU), Intubation

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