scholarly journals Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study

2015 ◽  
Vol 32 (4) ◽  
pp. 397-402 ◽  
Author(s):  
Atac Celik ◽  
Mustafa Ozcetin ◽  
Omer Ates ◽  
Fatih Altunkas ◽  
Kayihan Karaman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Premature Coronary Artery Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of ◽  
Artery Disease ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Effects of Endothelial Nitric Oxide Synthase, Interleukin-6 Gene Polymorphisms and Asymmetric Dimethylarginine Levels on Risk Factors and Lesion Sites in Peripheral Artery Disease

2009 ◽  
Vol 37 (4) ◽  
pp. 1003-1010
Author(s):  
AK Tuygun ◽  
M Keser ◽  
A Tuygun ◽  
B Ketenci ◽  
Y Şensöz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Asymmetric Dimethylarginine ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

This study investigated risk factors for atherosclerosis and their relationship with lesion sites. Patients ( n = 160) with peripheral artery disease (PAD) completed a questionnaire regarding risk factors for PAD. Endothelial nitric oxide synthase (eNOS) and interleukin (IL)-6 gene polymorphisms and asymmetric dimethylarginine (ADMA) levels were measured. Patients with coronary artery disease had significantly higher ratios of eNOS T/C and C/C genotypes, which include the C allele, than the T/T genotype. The IL-6 gene polymorphism distribution ratios for patients with over four risk factors were significantly different compared with other patients, with a higher rate of the C/C genotype. ADMA levels did not show any significant relationship to risk factors or polymorphism. Levels were, however, slightly higher in femoral lesion sites. The results support a model in which the C/C genotype of eNOS and IL-6 gene polymorphisms promote PAD development. The eNOS C/C genotype may have an independent effect, whereas the effects of the IL-6 C/C genotype are seen in conjunction with other risk factors.

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