scholarly journals Limb salvage surgery of primary and metastatic bone tumors of the lower extremity: Functional outcomes and survivorship of modular endoprosthetic reconstruction

2021 ◽  
Vol 55 (2) ◽  
pp. 147-153
Author(s):  
Osman Mert Topkar ◽  
◽  
Omer Sofulu ◽  
Evrim Sirin ◽  
Bulent Erol ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Limb Salvage ◽  
Functional Outcomes ◽  
Bone Tumors ◽  
Salvage Surgery ◽  
Limb Salvage Surgery ◽  
Endoprosthetic Reconstruction

Functional Outcomes After Limb-Salvage Surgery and Endoprosthetic Reconstruction With an Expandable Prosthesis: A Report of 4 Cases

2009 ◽  
Vol 90 (6) ◽  
pp. 1039-1047 ◽  
Author(s):  
Kathleen Beebe ◽  
Kimberly J. Song ◽  
Ellen Ross ◽  
Benjamin Tuy ◽  
Francis Patterson ◽  
...  
Keyword(s):  
Limb Salvage ◽  
Functional Outcomes ◽  
Salvage Surgery ◽  
Limb Salvage Surgery ◽  
Endoprosthetic Reconstruction

Poster 46: Functional Outcomes After Limb Salvage Surgery and Endoprosthetic Reconstruction With an Expandable Prosthesis: A Case Series

2008 ◽  
Vol 89 (11) ◽  
pp. e35
Author(s):  
Kimberly J. Song ◽  
Kathleen Beebe ◽  
Joseph Benevenia ◽  
Francis Patterson ◽  
Ellen Ross ◽  
...  
Keyword(s):  
Limb Salvage ◽  
Functional Outcomes ◽  
Salvage Surgery ◽  
Case Series ◽  
Limb Salvage Surgery ◽  
Endoprosthetic Reconstruction

Limb salvage surgery for malignant bone tumors of the extremities in children and adolescents

2009 ◽  
Vol 8 (11) ◽  
pp. 631-637 ◽  
Author(s):  
Zhen Wang ◽  
Zheng Guo ◽  
Xiangdong Li ◽  
Luyu Huang ◽  
Qiang Ji ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Limb Salvage ◽  
Bone Tumors ◽  
Salvage Surgery ◽  
Limb Salvage Surgery ◽  
Malignant Bone Tumors

Influence of Chemotherapy on Perioperative Complications in Limb-Salvage Surgery for Bone Tumors

Limb Salvage ◽  
1991 ◽  
pp. 497-507
Author(s):  
D. J. McDonald ◽  
R. Capanna ◽  
F. Gherlinzoni ◽  
M. Campanacci ◽  
A. Ferruzzi ◽  
...  
Keyword(s):  
Limb Salvage ◽  
Bone Tumors ◽  
Salvage Surgery ◽  
Perioperative Complications ◽  
Limb Salvage Surgery

Does neo-adjuvant chemotherapy increase the risk of infection after limb salvage surgery for bone tumors?

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 20532-20532
Author(s):  
S. Sankaranarayanan ◽  
V. Sokolovskiy ◽  
V. Voloshin ◽  
M. Aliev ◽  
V. Zubikov ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Limb Salvage ◽  
Bone Tumors ◽  
Salvage Surgery ◽  
Limb Salvage Surgery ◽  
Team Approach ◽  
Group A ◽  
Neo Adjuvant Chemotherapy ◽  
Group B

20532 Background: Neo-adjuvant chemotherapy is commonly used to eradicate the micro metastases and to prepare the patient for limb-salvage surgery. It helps the surgeon to get good oncological margin intraoperatively. Methods: Between the period of 1992 - 2005, 321 patients underwent limb salvage surgery for bone tumors at the Department of General Oncology (Bone & Soft tissue tumors), N. N. Blokhin Russian Cancer Research Center & Moscow Regional Clinical Research Institute, Moscow, Russian Federation. 230/321 patients (Group A) received neo-adjuvant chemotherapy. The course of chemotherapy ranges from 2 to 11 cycles. 95/321 patients (Group B) did not receive neo-adjuvant chemotherapy. The histological diagnoses were: 155 - High grade osteosarcoma, 38 - Giant cell tumor, 36 - Malignant fibrous histiocytoma, 29 - Chondrosarcoma, 25 - Periosteal osteosarcoma, 21 - Metastasis from other organs and 17 - Ewing's tumor. Results: In Group A, 27 patients (11.7%) and in Group B, 7 (7.3%) had infection of endoprosthetic bed. Suppression of the immune system by chemotherapeutic agents is the main reason for the higher incidence of infection in Group A. All the 27 patients in Group A and 2 patients in Group B had revisional endoprosthetic replacement. In group A 7/27 and in Group B none of the 7 patients died of post operative infection. The follow-up ranged from 1 - 13 years (mean follow-up 6 years). Discussion: In our opinion, it has a major disadvantage, i.e. it increases the risk of postoperative infection. How best to combine this drug is still unknown. In the future, therapy for bone tumors should be enhanced by advances in pharmacology, immunology, and molecular genetics that will lead to more efficacious, specific and less toxic treatments. An interdisciplinary team approach is needed in order to advance the goal of local tumor control, limb salvage with optimum extremity function, minimal morbidity and improved long term survival. No significant financial relationships to disclose.

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