Synthesis and characterization of some new 4-heteroaryl quinazoline and fused triazolo quinazoline derivatives

A series of palladium(II) halo complexes of the types [PdX 2 L 2 ].nH 2 O {n = 0, X = Cl, L = L 2 , L 4 and L 5 ; X = Br, L = L 2 ; n = 1, X = Cl, L = L 1 and L 3 } and Pd 2 X 4 L 3 [X = Br, L = L 1 , L 3 , L 4 and L 5 ] were prepared where L is 6-R-5,6- dihydrobenzoimidazo quinazoline (R-Diq; where R = ethyl: L 1 / n or i-propyl: L 2 , L 3 / n or i-butyl: L 4 , L 5 ) and characterized by elemental analyses, conductivity measurements, TGA, infrared, electronic, NMR and mass spectral techniques. Based on these studies monomeric/dimeric structure with a square planar geometry around the metal ion was proposed for all the complexes. Some of the complexes were investigated for anti-microbial activity.

Download Full-text

Synthesis and Characterization of Some Quinazoline Derivatives as Potential Antimicrobial Agents under Microwave Irradiation

Bulletin of the Korean Chemical Society ◽

10.5012/bkcs.2007.28.12.2338 ◽

2007 ◽

Vol 28 (12) ◽

pp. 2338-2343 ◽

Cited By ~ 4

Keyword(s):

Microwave Irradiation ◽

Antimicrobial Agents ◽

Synthesis And Characterization ◽

Quinazoline Derivatives

Download Full-text

Synthesis and Characterization of 4-(3′-Chlorophenylamino)-6-Methoxy Quinazoline Derivatives

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.634-638.1215 ◽

2013 ◽

Vol 634-638 ◽

pp. 1215-1218

Author(s):

He Ping Yan ◽

Du Shu Huang ◽

Ju Cheng Zhang

Keyword(s):

1H Nmr ◽

Elemental Analysis ◽

13C Nmr ◽

Synthesis And Characterization ◽

Quinazoline Derivatives

Five compounds of 4-(3-Chlorophenylamino)-6-methoxy quinazoline compounds, including 7-(3-(o-tolyloxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(m-tolyloxy) propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(p-tolyloxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(2,6-dimethylphenoxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-phenoxypropoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,were synthesized from N′-(5-(3-chloropropoxy)-2-cyano- 4-methoxyphenyl)- N, N-dimethylformamidine by cyclization，etheration, in the yield of 68.3%、53.8%、61.4%、75.6% and 87.4% respectively. Their structures were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis.

Download Full-text

Synthesis and Characterization of 7 - (3 - (substituted-phenoxy) propoxy) Quinazoline Derivatives

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.781-784.1003 ◽

2013 ◽

Vol 781-784 ◽

pp. 1003-1006

Author(s):

He Ping Yan ◽

Gui Ping Ouyang

Keyword(s):

Elemental Analysis ◽

Synthesis And Characterization ◽

H Nmr ◽

Quinazoline Derivatives ◽

C Nmr

Four compounds of 7-(3- (substituted-phenoxy) propoxy) quinazoline compounds, including 7-(3-(2,4-dichlorophenoxy) propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(2-chlo-rophenoxy) propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(4-chlorophenoxy) prop-oxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(naphthalen-3-yloxy) propoxy)-N-(3-chl-orophenyl)-6-methoxyquinazolin-4-amine, were synthesized fromN-(5-(3-chloropropoxy)-2-cyano-4-methoxyphen-yl)-N, N-dimethylformamidine by cyclization,etheration, in the yield of 45.9%50.6%56.34% and 80.6% respectively. Their structures were characterized by IR,1H NMR,13C NMR, MS and elemental analysis.

Download Full-text