Synthesis and Characterization of 4-(3′-Chlorophenylamino)-6-Methoxy Quinazoline Derivatives
2013 ◽
Vol 634-638
◽
pp. 1215-1218
Five compounds of 4-(3-Chlorophenylamino)-6-methoxy quinazoline compounds, including 7-(3-(o-tolyloxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(m-tolyloxy) propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(p-tolyloxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-(2,6-dimethylphenoxy)propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,7-(3-phenoxypropoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine,were synthesized from N′-(5-(3-chloropropoxy)-2-cyano- 4-methoxyphenyl)- N, N-dimethylformamidine by cyclization,etheration, in the yield of 68.3%、53.8%、61.4%、75.6% and 87.4% respectively. Their structures were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis.
2010 ◽
Vol 75
(11)
◽
pp. 1463-1471
◽
2010 ◽
Vol 16
(1)
◽
pp. 89-95