scholarly journals Are MicroRNA 190 and MicroRNA95-3P in the Circulation Can Be Used As Predictive Bioindicators in Differentiated Thyroid Cancer in Patients with Atypia of Undetermined Significance Based on Thyroid Fine Needle Aspiration Biopsy Results?

2020 ◽  
Author(s):  
Mustafa Gökhan Ünsal ◽  
Erdem Barış Cartı ◽  
Mustafa Ünübol ◽  
Elif Duygu Topan ◽  
Zehra Erdemir ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Atypical Cells ◽  
Thyroid Fine Needle Aspiration ◽  
Needle Aspiration Biopsy ◽  
Undetermined Significance

INTRODUCTION: It is not always possible to make a definitive diagnosis preoperatively with thyroid fine needle aspiration biopsy. Decision making is quite complicated in cases with atypical cells of undetermined significance. MicroRNAs have been shown to be associated with the development of neoplasia. For this purpose, we aimed to investigate the circulating microRNA 190 and microRNA 95-3P levels as a biomarker to distinguish benign and malign cases with preoperative atypical cells of undetermined significance diagnosis. METHODS: Patients with preoperative atypical cells of undetermined significance.diagnosis were included in the study. 29 malign and 29 benign patients were included. Venous blood samples isolated using a specific miRNA kit. RESULTS: According to the postoperative pathology results statistically significant between circulating miRNA 190 and miRNA 95-3p between cases with thyroid cancer. differences were detected. DISCUSSION AND CONCLUSION: It can be asserted that miRNA 95 and miRNA 190 assessment can help to differentiate thyroid cancer from benign thyroid nodules and may be useful in avoiding unnecessary surgery in patients with atypical cells of undetermined significance results.

Surgeon-performed ultrasound-guided thyroid fine-needle aspiration biopsy: Evaluation of 470 biopsies

2013 ◽  
Vol 85 (6) ◽  
pp. 380-385 ◽  
Author(s):  
Oktay Irkorucu ◽  
Enver Reyhan ◽  
Kamuran Cumhur Değer ◽  
Pelin Demirtürk ◽  
Hasan Erdem ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Thyroid Fine Needle Aspiration ◽  
Needle Aspiration Biopsy

scholarly journals Surgical Outcome of Thyroid Nodules with Atypia of Undetermined Significance and Follicular Lesion of Undetermined Significance in Fine Needle Aspiration Biopsy

2017 ◽  
Vol 9 (3) ◽  
pp. 100-103
Author(s):  
Saad Alqahtani ◽  
Saif Alsobhi ◽  
Riyadh I Alsalloum ◽  
Saleh N Najjar ◽  
Hindi N Al-Hindi
Keyword(s):  
Fine Needle Aspiration ◽  
Surgical Outcome ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Risk Of Malignancy ◽  
Needle Aspiration Biopsy ◽  
Undetermined Significance

ABSTRACT Aim To correlate selected clinical and ultrasonographic (US) characteristics with the final histopathological diagnosis in patients with atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS), and whether this information can be used in planning the surgical approach. Materials and methods It is a retrospective study including the operated cases of AUS/FLUS from 2011 to 2014 treated at one center. Results This cohort included 87 women and 28 men. To test for independence between categorical variables, the chi-square test was used. There was no significant correlation between age or US variables and final pathological diagnosis. However, final diagnosis of malignancy was higher in men compared with women (64.3 and 41.4% respectively; p = 0.035). Furthermore, a significant association between the diagnosis of repeated fine needle aspiration biopsy (FNAB) and the final pathological diagnosis was noted (benign vs malignant, p = 0.005). Conclusion The FNAB has a significant role in the assessment of thyroid nodules. Our results showed no correlation between age, US variables, and the risk of malignancy. Male gender is associated with higher risk of malignancy. Clinical significance Determining the risk of malignancy and prediction of surgical outcome may help triaging cases for repeat FNA or proceeding to surgery. How to cite this article Alqahtani S, Alsobhi S, Alsalloum RI, Najjar SN, Al-Hindi HN. Surgical Outcome of Thyroid Nodules with Atypia of Undetermined Significance and Follicular Lesion of Undetermined Significance in Fine Needle Aspiration Biopsy. World J Endoc Surg 2017;9(3):100-103.

Sign in / Sign up

Export Citation Format

Share Document