Peripheral Nerve Sheath Tumor of the Vagus Nerve in a Dog

A peripheral nerve sheath tumor was diagnosed in a female, neutered Labrador retriever with a 6 mo history of coughing, retching, ptyalism, and left-sided Horner's syndrome. Computed tomography scan of the neck revealed a mass lesion between the carotid artery and esophagus in the mid-cervical region. Exploratory surgery was performed and an 18 cm section of thickened vagus nerve was excised. Histopathological findings and immunochemistry staining confirmed a malignant peripheral nerve sheath tumor. The tumor showed microscopic signs of malignancy, but there were no macroscopic signs of local extension or distant metastasis. This report documents a peripheral nerve sheath tumor of rare origin in dogs.

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Malignant Peripheral Nerve Sheath Tumor of the Infraorbital Nerve

Craniomaxillofacial Trauma & Reconstruction ◽

10.1055/s-0035-1563698 ◽

2016 ◽

Vol 9 (2) ◽

pp. 170-174

Author(s):

JoséLuis D'Addino ◽

Laura Piccoletti ◽

MaríaMercedes Pigni ◽

Maria José Rodriguez Arenas de Gordon

Keyword(s):

Peripheral Nerve ◽

Chronic Atrial Fibrillation ◽

Radical Resection ◽

Infraorbital Nerve ◽

Malignant Schwannoma ◽

Ocular Motility ◽

Nerve Sheath Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath ◽

History Of

The objective of this study is to report a large, rare, and ulcerative infiltrated skin lesion. Its diagnosis, therapeutic management, and progress are described. The patient is a 78-year-old white man, who presented with a 12-month ulcerative perforated lesion that had affected and infiltrated the skin, with easy bleeding. He had a history of hypertension, although controlled, was a 40-year smoker, had chronic atrial fibrillation, diabetes, and microangiopathy. During the consultation, the patient also presented with ocular obstruction due to an inability to open the eye. He mentioned having reduced vision. The computed tomography scan showed upper maxilla osteolysis without eye involvement. We underwent a radical resection in which upper maxilla and the anterior orbital margin were included. We used a Becker-type flap that allowed us to rebuild the cheek and to complete a modified neck dissection. Progress was favorable; the patient recovered ocular motility and his vision improved to 20/200. The final biopsy result was “malignant peripheral nerve sheath tumor, malignant schwannoma.” Malignant schwannoma of the peripheral nerve is extremely rare. The total resection and reconstruction being completed in one surgery represented a challenge due to the difficulty in obtaining tissues in addition to the necessity of an oncological resection.

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Malignant peripheral nerve sheath tumor of the vagus nerve in a teenager with the neurofibromatosis 1 gene mutation: a case report

Journal of Pediatric Surgery ◽

10.1016/j.jpedsurg.2011.04.058 ◽

2011 ◽

Vol 46 (8) ◽

pp. e9-e12

Author(s):

Enrico Sesenna ◽

Alice Sara Magri ◽

Domenico Corradi ◽

Teore Ferri ◽

Andrea Ferri

Keyword(s):

Case Report ◽

Peripheral Nerve ◽

Vagus Nerve ◽

Gene Mutation ◽

Neurofibromatosis 1 ◽

Nerve Sheath Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath

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Intrathoracic malignant peripheral nerve sheath tumor with poor outcome: a case report

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2010.2681 ◽

2010 ◽

Vol 10 (4) ◽

pp. 328-330 ◽

Cited By ~ 5

Author(s):

Violeta Kolarov ◽

Jelena Stanić ◽

Živka Eri ◽

Biljana Zvezdin ◽

Marija Kojičić ◽

...

Keyword(s):

Peripheral Nerve ◽

Nerve Sheath Tumor ◽

Lethal Outcome ◽

Body Mass Loss ◽

Large Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath ◽

Progressive Dyspnea ◽

History Of ◽

The Right

We report a case of intrathoracic malignant peripheral nerve sheath tumor in a 65-year old woman revealed after a few-month history of progressive dyspnea, appetite and body mass loss. The chest magnetic resonance (MR) examination revealed the presence of a large tumor occupying the mediastinum and a major portion of the right hemithorax. The diagnostic tumor sample was obtained by parasternal biopsy in local anesthesia. The surgical resection of the tumor could not be performed due to its excessive size, intrathoracic involvement and bad respiratory reserves of a patient. The chemotherapy and irradiation were performed as palliative measures. The lethal outcome appeared 10 months after the diagnosis was established.

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Malignant Peripheral Nerve Sheath Tumor of the Superior Mediastinal Vagus Nerve in a Neurofibromatosis Type 1 Patient

Haigan ◽

10.2482/haigan.50.157 ◽

2010 ◽

Vol 50 (2) ◽

pp. 157-161 ◽

Cited By ~ 1

Author(s):

Kikuo Shigemitsu ◽

Gen Ito ◽

Akira Shiraki ◽

Takashi Abe ◽

Morihide Ando ◽

...

Keyword(s):

Peripheral Nerve ◽

Vagus Nerve ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Nerve Sheath Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath

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Recurrent Malignant Peripheral Nerve Sheath Tumor Presenting As an Asymptomatic Intravenous Thrombus Extending to the Heart: A Case Report

10.21203/rs.3.rs-942103/v1 ◽

2021 ◽

Author(s):

Toru Hirozane ◽

Robert Nakayama ◽

Sayaka Yamaguchi ◽

Tomoaki Mori ◽

Naofumi Asano ◽

...

Keyword(s):

Peripheral Nerve ◽

Radial Nerve ◽

Subclavian Vein ◽

Tumor Thrombus ◽

Venous Invasion ◽

Nerve Sheath Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath ◽

History Of ◽

The Right

Abstract Background: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma mainly treated via surgical resection. Herein, we report a case of MPNST wherein a massive tumor thrombus extended to the major veins and heart.Case presentation: A 39-year-old female with a history of neurofibromatosis type 1 developed MPNST from the right radial nerve. In addition to adjuvant chemotherapy, she underwent wide tumor resection and concomitant radial nerve resection, followed by postoperative radiotherapy. Histological evaluation revealed marked venous invasion. The 2-year follow-up CT revealed an asymptomatic recurrent tumor thrombus extending from the right subclavian vein to the heart. An urgent life-saving operation was performed to ligate the base of the right subclavian vein and remove the entire intravenous thrombus that extended to the right ventricle. The remaining tumor in the right subclavian vein increased in size 3 months after thrombectomy. After confirming the absence of any metastatic lesions, the patient underwent extended forequarter amputation to achieve surgical remission. One year later, a new metastasis to the right diaphragm was safely resected. The patient remains alive without any evidence of disease 2 years after the extended forequarter amputation. Conclusions: In cases of a previous history of microscopic venous invasion, recurrence can occur as a massive tumor thrombus that extends to the great vessels.

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Recurrent malignant peripheral nerve sheath tumor presenting as an asymptomatic intravenous thrombus extending to the heart: a case report

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02473-2 ◽

2022 ◽

Vol 20 (1) ◽

Author(s):

Toru Hirozane ◽

Robert Nakayama ◽

Sayaka Yamaguchi ◽

Tomoaki Mori ◽

Naofumi Asano ◽

...

Keyword(s):

Peripheral Nerve ◽

Radial Nerve ◽

Subclavian Vein ◽

Tumor Thrombus ◽

Venous Invasion ◽

Nerve Sheath Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath ◽

History Of ◽

The Right

Abstract Background Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma mainly treated via surgical resection. Herein, we report a case of MPNST wherein a massive tumor thrombus extended to the major veins and heart. Case presentation A 39-year-old female with a history of neurofibromatosis type 1 developed MPNST from the right radial nerve. In addition to adjuvant chemotherapy, she underwent wide tumor resection and concomitant radial nerve resection, followed by postoperative radiotherapy. Histological evaluation revealed marked venous invasion. The 2-year follow-up CT revealed an asymptomatic recurrent tumor thrombus extending from the right subclavian vein to the heart. An urgent life-saving operation was performed to ligate the base of the right subclavian vein and remove the entire intravenous thrombus that extended to the right ventricle. The remaining tumor in the right subclavian vein increased in size 3 months after thrombectomy. After confirming the absence of any metastatic lesions, the patient underwent extended forequarter amputation to achieve surgical remission. One year later, a new metastasis to the right diaphragm was safely resected. The patient remains alive without any evidence of disease 2 years after the extended forequarter amputation. Conclusions In cases of a previous history of microscopic venous invasion, recurrence can occur as a massive tumor thrombus that extends to the great vessels.

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Malignant peripheral nerve sheath tumor of the vagus nerve: an uncommon cause of progressive dyspnea

Radiologia Brasileira ◽

10.1590/0100-3984.2016.0055 ◽

2017 ◽

Vol 50 (6) ◽

pp. 412-413 ◽

Cited By ~ 1

Author(s):

Felipe Welter Langer ◽

Daiane dos Santos ◽

Giordano Rafael Tronco Alves ◽

Gustavo Suertegaray ◽

Carlos Jesus Pereira Haygert

Keyword(s):

Peripheral Nerve ◽

Vagus Nerve ◽

Nerve Sheath Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath ◽

Progressive Dyspnea

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Radiation-Induced Malignant Peripheral Nerve Sheath Tumor of the Vagus Nerve Following Radiation Treatment of Cervical Paraganglioma

Journal of Neurological Surgery Reports ◽

10.1055/s-0040-1718408 ◽

2020 ◽

Vol 81 (04) ◽

pp. e66-e70

Author(s):

Gregory P. Lekovic ◽

Gautam U. Mehta ◽

Anne K. Maxwell ◽

Kevin A. Peng ◽

Derald E. Brackmann

Keyword(s):

Peripheral Nerve ◽

Vagus Nerve ◽

Radiation Treatment ◽

Rare Complication ◽

External Beam Radiation ◽

Nerve Sheath Tumor ◽

Beam Radiation ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath ◽

Radiation Induced

AbstractRadiation-induced sarcoma is a known but rare complication of radiation treatment for skull base paraganglioma. We present the cases of a female patient with multiple paraganglioma syndrome treated with external beam radiation treatment who presented 4 years later with a malignant peripheral nerve sheath tumor of the vagus nerve.

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