scholarly journals Malignant transformation of plexiform neurofibroma

2021 ◽  
Author(s):  
Francesco Buemi
Keyword(s):  
Malignant Transformation ◽  
Plexiform Neurofibroma

scholarly journals Isolated Plexiform Neurofibroma of the Tongue

2013 ◽  
Vol 5 (02) ◽  
pp. 127-129 ◽  
Author(s):  
Abhishek Sharma ◽  
Parama Sengupta ◽  
Anjan KR Das
Keyword(s):  
Malignant Transformation ◽  
Rare Case ◽  
Benign Tumor ◽  
Clinical Presentation ◽  
Plexiform Neurofibroma ◽  
Common Variant ◽  
Benign Tumors ◽  
Plexiform Neurofibromas ◽  
Neural Origin ◽  
Rare Benign Tumor

ABSTRACTNeurofibromas (NF) are benign tumors of neural origin, of which roughly 90% appear as solitary lesions. They are classified into cutaneous, subcutaneous, and plexiform subtypes. Plexiform neurofibromas are the least common variant and usually are pathognomonic for NF I. Here, we present a very rare case of isolated plexiform neurofibroma with a painless enlarging mass of the tongue of an 11-year-old girl. This rare benign tumor has the potential for malignant transformation, and the diagnosis was difficult owing to the patient's age and to the insidious clinical presentation. The present case is a diffuse isolated plexiform neurofibroma of the tongue that was not associated with neurofibromatosis that was treated with intraoral surgery.

Early atypical malignant transformation of a plexiform neurofibroma in a 4-year-old boy with Neurofibromatosis 1

2005 ◽  
Vol 45 (1) ◽  
pp. 76-77 ◽  
Author(s):  
M. Hasiotou ◽  
K. Stefanaki ◽  
D. Danassi-Afentaki ◽  
G. Sfakianos ◽  
M. Moschovi ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Plexiform Neurofibroma ◽  
Neurofibromatosis 1

Malignant transformation in a plexiform neurofibroma of the median nerve

1984 ◽  
Vol 9 (4) ◽  
pp. 583-587 ◽  
Author(s):  
Geoffrey D. Williams ◽  
Saul Hoffman ◽  
Ira S. Schwartz
Keyword(s):  
Median Nerve ◽  
Malignant Transformation ◽  
Plexiform Neurofibroma

scholarly journals Nonoperative Management May Be a Viable Approach to Plexiform Neurofibroma of the Porta Hepatis in Patients with Neurofibromatosis-1

HPB Surgery ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Natesh Yepuri ◽  
Rana Naous ◽  
Camille Richards ◽  
Dilip Kittur ◽  
Ajay Jain ◽  
...  
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Pediatric Patients ◽  
Case Reports ◽  
Plexiform Neurofibroma ◽  
Tumor Resection ◽  
Neurofibromatosis 1 ◽  
Porta Hepatis ◽  
Viable Approach

Background. Plexiform neurofibroma (PNF) in the porta hepatis (PH) is an unusual manifestation of neurofibromatosis-1 (NF-1). Resection is often recommended given the risk of malignant transformation. We encountered a challenging case in clinical practice which prompted us to report our findings and perform a systematic review on the management of these tumors. Methods. We reported the case of a 31-year-old woman with NF-1 and PNF of the PH. PRISMA 2009 guidelines were followed for systematic review. Results. Our patient was found to have unresectable disease at exploration. After >5 years of follow-up, she continued to have stable disease on imaging. We identified 12 studies/case reports including 10 adult and 6 pediatric patients with PNF of PH. None of the 7 adult patients with NF-1 and PNF of PH underwent a successful tumor resection. All pediatric patients were managed with surveillance alone. All but one pediatric patient had NF-1. None of the reported cases of PNF of PH had malignant transformation. Conclusion. Our findings suggest that PNFs of PH in the setting of NF-1 are often unresectable and may have an indolent course. Surveillance alone may be a reasonable option in some patients; however, further studies are needed.

scholarly journals Malignant Transformation of Plexiform Neurofibroma to MPNST while on MEK Inhibitor

2021 ◽  
Author(s):  
Samir Fasih ◽  
Suganth Suppiyah ◽  
Jane Barron ◽  
Carolina Barnett-Tapia ◽  
Roger Avery ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Plexiform Neurofibroma ◽  
Mek Inhibitor

scholarly journals Isolated giant plexiform neurofibroma of lower back: a rare case presentation

2020 ◽  
Vol 7 (2) ◽  
pp. 581
Author(s):  
Devansh Mishra ◽  
Nitin Wasnik ◽  
Priyanka Sakarkar
Keyword(s):  
Malignant Transformation ◽  
Rare Case ◽  
Plexiform Neurofibroma ◽  
Neurofibromatosis Type ◽  
Lower Back ◽  
Patient Reported ◽  
Rare Benign Tumor ◽  
Married Female

Plexiform neurofibroma is a rare benign tumor of the peripheral tissue cells that develops in the perineurium that is often considered pathognomonic of neurofibromatosis type 1 (NF1 or von Recklinghausen disease). They occur most frequently in the craniomaxillofacial region, rarely on back and extremities. They are extremely vascular and there is 15-20% potential for malignant transformation. A 35-year-old married female presented with painless swelling in left lower back that began at around 8 years of age. The swelling gradually increased in size. The patient reported embarrassment over the disfigurement caused by the mass. Her medical history was unremarkable and none of the relatives was known to be affected. Surgical resection of the swelling with primary closure was done. Histopathology findings were consistent with neurofibromatosis. Hereby reporting a rare case of isolated plexiform neurofibroma of lower back which was surgically cured as a perusal of rare entity. We also try to emphasize on the need of sprightful clinical diagnosis with multidisciplinary approach in the management of these type of tumors. Finally, we insist on the need of a long term clinical and radiological follow-up of these patients to assess  post resection recurrence or malignant transformation.

Application of Transmission Electron Microscope and Scanning Electron Microscope in experimental tumor studies

1990 ◽  
Vol 48 (3) ◽  
pp. 306-307
Author(s):  
Gao Fengming
Keyword(s):  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Malignant Transformation ◽  
Transmission Electron Microscope ◽  
Experimental Tumor ◽  
Transmission Electron ◽  
Embryo Cells ◽  
Tumor Studies ◽  
Scanning Electron

Transmission electron microscope(TEM) and scanning electron microscope(SEM) were widely used in experimental tumor studies. They are useful for evaluation of cellular transformation in vitro, classification of histological types of tumors and treating effect of tumors. We have obtained some results as follows:1. Studies on the malignant transformation of mammalian cells in vitro. Syrian golden hamster embryo cells(SGHEC) were transformed in vitro by ThO2 and/or ore dust. In a few days after dust added into medium, some dust crystals were phagocytized. Two weeks later, malignant transformation took place. These cells were of different size, nuclear pleomorphism, numerous ribosomes, increasing of microvilli on cell surface with various length and thickness, and blebs and ruffles(Figs. 1,2). Myelomonocytic leukemic transformation of mouse embryo cells(MEC) was induced in vitro by 3H-TdR. Transformed cells were become round from fusiform. The number of mitochondria and endoplasmic reticulum was reduced, ribosomes and nucleoli increased, shape of nuclei irregular, microvilli increased, and blebs and ruffles appeared(Fig. 3).

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