scholarly journals Role of Insulin-like Growth Factor-I Receptor (IGF-IR) in Survival Kinetics and Radioresistance of Mouse Embryo Fibroblasts in a Hypoxic Environment.

2002 ◽  
Vol 69 (2) ◽  
pp. 107-118
Author(s):  
Kiyoshi OKOCHI
Keyword(s):  
Growth Factor ◽  
Mouse Embryo ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Mouse Embryo Fibroblasts ◽  
Hypoxic Environment ◽  
Growth Factor I ◽  
Embryo Fibroblasts

scholarly journals Insulin-like growth factor I receptor signaling in transformation by src oncogenes.

1997 ◽  
Vol 17 (7) ◽  
pp. 3744-3754 ◽  
Author(s):  
B Valentinis ◽  
A Morrione ◽  
S J Taylor ◽  
R Baserga
Keyword(s):  
Growth Factor ◽  
Mouse Embryo ◽  
Soft Agar ◽  
Insulin Like Growth Factor ◽  
Full Transformation ◽  
Factor I ◽  
Mouse Embryo Fibroblasts ◽  
Igf I ◽  
Growth Factor I ◽  
Embryo Fibroblasts

R- cells, a line of mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I (IGF-I) receptor genes, are refractory to transformation by several viral and cellular oncogenes. Using colony formation in soft agar as a measure of full transformation, we report here that R- cells can be transformed by v-src, although they still cannot be transformed by the activated c-src527 (mutation at tyrosine 527 to phenylalanine), which readily transforms mouse embryo cells with a wild-type number of IGF-I receptors (W cells). Although v-src is a more potent inducer of tyrosine phosphorylation than c-src527, the extent of phosphorylation of either insulin receptor substrate 1 or Shc, two of the major substrates of the IGF-I receptor, does not seem sufficiently different to explain the qualitative difference in soft agar growth. v-src, however, is considerably more efficient than c-src527 in its ability to tyrosyl phosphorylate, in R- cells, the focal adhesion kinase, Stat1, and p130cas. These results indicate that v-src, but not c-src527, can bypass the requirement for a functional IGF-I receptor in the full transformation of mouse embryo fibroblasts and suggest that qualitative and quantitative differences between the two oncogenes can be used to identify some of the signals relevant to the mechanism(s) of transformation.

scholarly journals Transformation of Late Passage Insulin-Like Growth Factor-I Receptor Null Mouse Embryo Fibroblasts by SV40 T Antigen

2006 ◽  
Vol 66 (8) ◽  
pp. 4233-4239 ◽  
Author(s):  
Susan L. Spence ◽  
Arthur L. Shaffer ◽  
Louis M. Staudt ◽  
Sewit Amde ◽  
Sutana Manney ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Embryo ◽  
T Antigen ◽  
Null Mouse ◽  
Insulin Like Growth Factor ◽  
Sv40 T Antigen ◽  
Factor I ◽  
Mouse Embryo Fibroblasts ◽  
Late Passage ◽  
Growth Factor I

The Role of the Insulin-like Growth Factor-I Receptor in Cancer

1995 ◽  
Vol 766 (1 Receptor Acti) ◽  
pp. 402-408 ◽  
Author(s):  
D. LEROITH ◽  
H. WERNER ◽  
S. NEUENSCHWANDER ◽  
T. KALEBIC ◽  
L. J. HELMAN
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I
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