scholarly journals Locally Advanced Pancreatic Head Cancer: Margin-Positive Resection or Bypass?

ISRN Surgery ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ulrich Friedrich Wellner ◽  
Frank Makowiec ◽  
Dirk Bausch ◽  
Jens Höppner ◽  
Olivia Sick ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Locally Advanced ◽  
Pancreatic Head ◽  
Resection Margins ◽  
Term Outcome ◽  
Term Survival ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer ◽  
Margin Positive

Pancreatic cancer is a highly aggressive disease with poor survival. The only effective therapy offering long-term survival is complete surgical resection. In the setting of nonmetastatic disease, locally advanced tumors constitute a technical challenge to the surgeon and may result in margin-positive resection margins. Few studies have evaluated the implications of the latter in depth. The aim of this study was to compare the margin-positive situation to palliative bypass procedures and margin-negative resections in terms of perioperative and long-term outcome. By retrospective analysis of prospectively maintained data from 360 patients operated for pancreatic cancer at our institution, we provide evidence that margin-positive resection still yields a significant survival benefit over palliative bypass procedures. At the same time, perioperative severe morbidity and mortality are not significantly increased. Our observations suggest that pancreatic cancer should be resected whenever technically feasible, including, cases of locally advanced disease.

Perioperative and Long-Term Outcome after Standard Pancreaticoduodenectomy, Additional Portal Vein and Multivisceral Resection for Pancreatic Head Cancer

2015 ◽  
Vol 19 (3) ◽  
pp. 438-444 ◽  
Author(s):  
Birte Kulemann ◽  
Jens Hoeppner ◽  
Uwe Wittel ◽  
Torben Glatz ◽  
Tobias Keck ◽  
...  
Keyword(s):  
Portal Vein ◽  
Pancreatic Head ◽  
Multivisceral Resection ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer

Surgery Indeed has an Important Role in Long-Term Outcome in Patients with Pancreatic Head Cancer

2013 ◽  
Vol 38 (6) ◽  
pp. 1558-1559
Author(s):  
Darko Zdravkovic ◽  
Dragoljub Bilanovic ◽  
Tomislav Randjelovic ◽  
Marija Zdravkovic ◽  
Srdjan Dikic
Keyword(s):  
Pancreatic Head ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer

Randomized clinical trial of long-term outcome after curative resection of pancreatic head cancer by post-operative intra-arterial infusion chemotherapy

2004 ◽  
Vol 11 (S2) ◽  
pp. S52-S52 ◽  
Author(s):  
S. Nakamori ◽  
A. Miyamoto ◽  
Y. Takahashi ◽  
M. Tsujie ◽  
S. Marubashi ◽  
...  
Keyword(s):  
Curative Resection ◽  
Pancreatic Head ◽  
Arterial Infusion ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Arterial Infusion Chemotherapy ◽  
Infusion Chemotherapy ◽  
Pancreatic Head Cancer

A phase II study of stereotactic radiotherapy after FOLFIRINOX for locally advanced pancreatic cancer (LAPC-1 trial): Long-term outcome

2021 ◽  
Vol 155 ◽  
pp. 232-236
Author(s):  
M.A. Teriaca ◽  
M. Loi ◽  
M. Suker ◽  
F.A.L.M. Eskens ◽  
C.H.J. van Eijck ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Phase Ii ◽  
Stereotactic Radiotherapy ◽  
Phase Ii Study ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Term Outcome ◽  
Long Term Outcome

63 Primary and adjuvant chemoradiotherapy for locally advanced pancreatic cancer: A phase I/II study with long term outcome

2006 ◽  
Vol 80 ◽  
pp. S19
Author(s):  
A.M. Brade ◽  
C. Townsley ◽  
C. Brezden-Masley ◽  
D. Hedley ◽  
M. MacLean ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Phase I ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Locally Advanced Pancreatic Cancer ◽  
Adjuvant Chemoradiotherapy ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Surgery Indeed has an Important Role in Long-Term Outcome in Patients with Pancreatic Head Cancer by Zdravkovic et al.

2014 ◽  
Vol 38 (8) ◽  
pp. 2192-2193
Author(s):  
David Petermann ◽  
Nicolas Demartines ◽  
Markus Schafer
Keyword(s):  
Pancreatic Head ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer

Short- and long-term outcome of pancreaticoduodenectomy with or without portal/superior mesenteric vein resection for pancreatic head cancer: A Japanese single hospital experience

Pancreatology ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. S34
Author(s):  
Meidai Kasai ◽  
Jun-ichiro Yamauchi ◽  
Kousuke Kanazawa ◽  
Ataru Satou ◽  
Yasuyuki Matuda ◽  
...  
Keyword(s):  
Superior Mesenteric Vein ◽  
Pancreatic Head ◽  
Term Outcome ◽  
Head Cancer ◽  
Long Term Outcome ◽  
Pancreatic Head Cancer ◽  
Mesenteric Vein ◽  
Short And Long Term ◽  
Vein Resection

Long-term outcome after neoadjuvant radiochemotherapy in locally advanced noninflammatory breast cancer and predictive factors for a pathologic complete remission: Results of a multivariate analysis.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 154-154
Author(s):  
Christiane Matuschek ◽  
Edwin Boelke ◽  
Hans Bojar ◽  
Stephan L. Roth ◽  
Matthias Peiper ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multivariate Analysis ◽  
Locally Advanced ◽  
Breast Conservation ◽  
Time Interval ◽  
Term Outcome ◽  
Term Survival ◽  
Long Term Outcome

154 Background: An earlier published series of neoadjuvant radio-chemotherapy (NRT-CHX) in locally advanced noninflammatory breast cancer (LABC) has now been updated with a follow-up of more than 15 years. Long-term outcome data and predictive factors for pathologic complete response (PCR) were analyzed. Methods: 315 LABC patients (cT1-cT4 /cN0-N1) were treated during 1991-1998 with NRT-CHX. Preoperative radiotherapy (RT) consisted of external beam radiation therapy (EBRT) of 50 Gy (5 × 2 Gy/week) to the breast and the supra-/infraclavicular lymph nodes combined with an electron boost in 214 cases afterwards or—in case of breast conservation—a 10-Gy interstitial boost with 192Ir afterloading before EBRT. Chemotherapy was administered prior to RT in 192 patients, and concomitantly in 113; 10 patients received no chemotherapy. The update of all follow up ended in November 2011. Age, tumor grade, nodal status, hormone receptor status, simultaneous vs. sequential CHX and the time interval between end of RT and surgery were examined in multivariate terms with as endpoint pCR and overall survival. Results: The total PCR rate after neoadjuvant RT-CHX reached 29.2 % with LABC breast conservation becoming possible in 50.8%. In initially node-positive cases (cN+), a complete nodal response (pN0) after NRT-CHX was observed in 56% (89/159). The multivariate analysis revealed that a longer time interval to surgery increased the probability for a pCR (HR 1,17 [95% CI 1,05-1,31], p<0,01). However, in large tumors (T3-T4) a significantly reduced pCR rate (HR 0.89 [95% CI 0.80 to 0.99], p = 0.03) could be obtained. Importantly, a pCR was the strongest prognostic factor for long-term survival (HR 0.28 [95% CI 0.19-0.56], p<0.001). Conclusions: A PCR identifies patients with a significant better prognosis for long-term survival. However, a long time interval to surgery (> 2 months) increases the probability of a pCR after NRT-CHX.

scholarly journals Current Status and Long-term Outcome of Neoadjuvant Chemoradiotherapy for Resectable Pancreatic Cancer

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S58
Author(s):  
K. Nakagawa ◽  
T. Akahori ◽  
K. Nakamura ◽  
T. Takagi ◽  
N. Ikeda ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Neoadjuvant Chemoradiotherapy ◽  
Current Status ◽  
Resectable Pancreatic Cancer ◽  
Term Outcome ◽  
Long Term Outcome
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