Unusual ischemic kidney injury presenting as slowly declining graft function and successful use of oral desmopressin in a kidney transplant recipient with subclinical central diabetes insipidus

2021 ◽  
Vol 95 (4) ◽  
pp. 208-214
Author(s):  
Shuzo Kaneko ◽  
Joichi Usui ◽  
Kunio Kawanishi ◽  
Ryota Ishii ◽  
Kazuhiro Takahashi ◽  
...  
2020 ◽  
Vol 10 (3) ◽  
pp. 174-179
Author(s):  
Flaviu Tosa ◽  
Roxana Manaila ◽  
Alina Elec ◽  
Tudor Moisoiu ◽  
Liviu Ghervan ◽  
...  

As coronavirus disease 2019 (COVID-19) caused by the novel virus SARS-CoV-2 is expanding worldwide, kidney involvement seems to be part of the spectrum of its effects. Moreover, the prognosis of the disease seems to be worse in immunocompromised patients when compared to the general population, with 4–5 times higher mortality rates. However, the overall impact on long-term function of the kidney graft is unknown. We report on a case of a 46-year-old kidney transplant recipient who was successfully treated for severe COVID-19 pneumonia. The clinical course was complicated by transient acute kidney injury, most likely due to tubulo-interstitial involvement, with return to the baseline of the creatinine level by the time of discharge. We discuss the characteristics and differential diagnosis of acute kidney injury, as well as management of immunosuppression in connection with overall clinical status and evolution of kidney function. The case is illustrative for dilemmas that transplant professionals may face in the absence of evidence-based, efficient COVID-19 therapy. The risk-benefit balance of the yet to be approved treatment strategies may be weighed differently in organ transplant recipients owing to their immunocompromised status and potential drug interactions with immunosuppressive therapy.


2016 ◽  
Vol 16 (11) ◽  
pp. 3278-3281 ◽  
Author(s):  
Z. Ebcioglu ◽  
C. Liu ◽  
R. Shapiro ◽  
M. Rana ◽  
F. Salem ◽  
...  

2008 ◽  
Vol 40 (7) ◽  
pp. 2435-2436
Author(s):  
Y.L. Thye ◽  
S.K. Lim ◽  
C.M. Wong ◽  
T.C. Keng ◽  
Y.B. Chong ◽  
...  

2021 ◽  
Vol 21 (6) ◽  
pp. 2298-2300
Author(s):  
Shai Chazin ◽  
Osaid Saqqa ◽  
Anil Paramesh ◽  
Sixto Giusti

2009 ◽  
Vol 87 (4) ◽  
pp. 618-619 ◽  
Author(s):  
Roberto C. Manfro ◽  
Jose A. Pedroso ◽  
Karla L. Pegas ◽  
Luiz Felipe S. Gonçalves

1996 ◽  
Vol 62 (10) ◽  
pp. 1509-1511 ◽  
Author(s):  
Motonobu Nishimura ◽  
Kenichi Yamada ◽  
Kazuyuki Matsushita ◽  
Kaoru Sakamoto ◽  
Takashi Saisu ◽  
...  

2020 ◽  
Vol 39 (2) ◽  
pp. 89-94
Author(s):  
Riza Madazlı ◽  
Didem Kaymak ◽  
Verda Alpay ◽  
Hakan Erenel ◽  
M. Tamer Dincer ◽  
...  

2019 ◽  
Vol 30 (9) ◽  
pp. 919-922 ◽  
Author(s):  
Gaetano Alfano ◽  
Francesco Fontana ◽  
Giacomo Mori ◽  
Emanuela Vicari ◽  
Giovanni Dolci ◽  
...  

Sirolimus (SIR) is a potent immunosuppressive agent with multiple proprieties. We report beneficial antiviral effects of SIR in an HIV-positive kidney transplant recipient who experienced low-level HIV-1 replication. The immunosuppressive agent was well tolerated by the patient, and no side effects were reported during follow-up. Despite immunosuppressive monotherapy, SIR ensured stable graft function.


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