scholarly journals Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism

2021 ◽  
Author(s):  
Takeshi Akiyoshi ◽  
Rina Naitou ◽  
Ayuko Imaoka ◽  
Mitsue Miyazaki ◽  
F. Peter Guengerich ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Time Dependent ◽  
Macrolide Antibiotics ◽  
Testosterone Metabolism ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition ◽  
Midazolam Metabolism

Combination of GSH Trapping and Time-Dependent Inhibition Assays as a Predictive Method of Drugs Generating Highly Reactive Metabolites

2011 ◽  
Vol 39 (7) ◽  
pp. 1247-1254 ◽  
Author(s):  
Shintaro Nakayama ◽  
Hideo Takakusa ◽  
Akiko Watanabe ◽  
Yoshihiro Miyaji ◽  
Wataru Suzuki ◽  
...  
Keyword(s):  
Time Dependent ◽  
Reactive Metabolites ◽  
Predictive Method ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Time-Dependent Inhibition of Oxotremorine-Induced Cerebral Hyperemia by N ω -Nitro- l -Arginine in Cats

Stroke ◽  
1995 ◽  
Vol 26 (11) ◽  
pp. 2160-2165 ◽  
Author(s):  
Charisse S. Tietjen ◽  
Jeffrey R. Kirsch ◽  
Nathalie Clavier ◽  
Richard J. Traystman
Keyword(s):  
Time Dependent ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition
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