scholarly journals Micronucleus Test of Picrorrhiza Rhizoma Aqueous Extract in Bone Marrow Cells of Male ICR Mice

2011 ◽  
Vol 27 (2) ◽  
pp. 119-123 ◽  
Author(s):  
In-Kwon Chung ◽  
Woo-Hyun Cheon ◽  
Sae-Kwang Ku
Keyword(s):  
Bone Marrow ◽  
Aqueous Extract ◽  
Bone Marrow Cells ◽  
Micronucleus Test ◽  
Icr Mice ◽  
Marrow Cells

scholarly journals Micronucleus Test of DHU001, a Polyherbal Formula, in Bone Marrow Cells of Male ICR Mice

2009 ◽  
Vol 25 (4) ◽  
pp. 225-230 ◽  
Author(s):  
Seong-Soo Roh ◽  
Hyeung-Sik Lee ◽  
Sae-Kwang Ku
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Micronucleus Test ◽  
Icr Mice ◽  
Marrow Cells

scholarly journals Micronucleus Test of PolycanTM, β-Glucan Originated from Aureobasidium, in Bone Marrow Cells of Male ICR Mice

2008 ◽  
Vol 24 (1) ◽  
pp. 11-15
Author(s):  
Hyeung-Sik Lee ◽  
Hyung-Rae Cho ◽  
Kun-Ju Yang ◽  
Seung-Bae Moon ◽  
Bok-Ryeon Park ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Micronucleus Test ◽  
Icr Mice ◽  
Marrow Cells

scholarly journals Effect of aqueous extract of Rosemary officinalis on cytotoxicity of CCL4 induced albino male mice

2018 ◽  
Vol 12 (1) ◽  
pp. 124-131
Author(s):  
Ruqaya M. Ibrahim
Keyword(s):  
Bone Marrow ◽  
Mitotic Index ◽  
Aqueous Extract ◽  
Bone Marrow Cells ◽  
Post Treatment ◽  
Rosemary Extract ◽  
Mutagenic Action ◽  
Male Mice ◽  
Micronucleus Formation ◽  
Marrow Cells

This study focused the line on the effect of aqueous extract of Rosemary officinalis, as well as, effect of toxic compound CCL4, on micronucleus formation and mitotic index assay in albino male mice. This work started at September 2017 at Biotechnology Research center \Al-Nahrain University, by using 20 albino male mice. The result indicated that aqueous extract of rosemary caused significant increased in mitotic index and decrease micronucleus formation for two doses tested 50,100 mg/kg in comparison with negative and positive controls, also the results revealed that CCL4 showed significant mutagenic action on biological system of treated mice by increased frequency of micronucleus formation and decreased the percentage of mitotic index in bone marrow cells. Pre-and post –treatment between aqueous extract and CCL4 were also made. The results of pre and post treatment with rosemary extract were also caused a significant decreased in micronucleus formation and increase the percentage of mitotic index for two doses 50,100 mg/kg  in comparison with its corresponding controls which caused increased in the frequencies of micronucleus formation and decrease the percentage of mitotic index in bone marrow cells. Conclusions: Rosemary officinalis enhanced immunity, reduced mutagenic effects against cytotoxicity of CCL4.

scholarly journals A Study of Micronucleus Induction with Methyl Formate and 2-Methylbutane in Bone Marrow Cells of Male ICR Mice

2010 ◽  
Vol 1 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Soo-Jin Kim ◽  
Kyung-Taek Rim ◽  
Min-Gu Kang ◽  
Jong-Kyu Kim ◽  
Yong-Hyun Chung ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Methyl Formate ◽  
Bone Marrow Cells ◽  
Icr Mice ◽  
Micronucleus Induction ◽  
Marrow Cells

scholarly journals In vivo genotoxicity of treated water containing the cylindrospermopsin-producer Cylindrospermopsis raciborskii

2014 ◽  
Vol 12 (3) ◽  
pp. 474-483 ◽  
Author(s):  
A. L. Fonseca ◽  
J. Da Silva ◽  
E. A. Nunes ◽  
S. M. F. O. Azevedo ◽  
R. M. Soares
Keyword(s):  
Bone Marrow ◽  
Comet Assay ◽  
Bone Marrow Cells ◽  
Micronucleus Test ◽  
Liver Cells ◽  
Cylindrospermopsis Raciborskii ◽  
Producer Strain ◽  
Treated Water ◽  
Marrow Cells

Cylindrospermopsin (CYN) is an alkaloid commonly produced by some cyanobacteria that has been implicated in outbreaks of human illness. The aim of this study was to investigate the genotoxicity of Cylindrospermopsis raciborskii cellular content (including CYN) and its byproducts resulting from chlorination during water treatment. DNA damage in blood and liver cells was analysed by the comet assay and micronucleus test (MN). Mice were injected intraperitoneally with the following treatments: (a) physiological saline, (b) treated water, (c) treated water plus C. raciborskii extract (CYN producer strain, CYPO-011 K), (d) C. raciborskii extract (CYN producer strain, CYPO-011 K), (e) C. raciborskii extract (CYN non producer strain), and (f) treated water plus C. raciborskii extract (CYN non producer strain) extract. After 48 h, samples were taken to perform tests (blood and liver cells to the comet assay and bone marrow to MN test). The CYPO-011 K had a genotoxic and mutagenic effects on liver and bone marrow cells. The group that received chlorine-treated water plus CYPO-011 K also exhibited genotoxic effects in the liver, as well as in the blood, and a mutagenic effect in blood marrow cells. The results emphasise the need of improving CYN monitoring in waters bodies in order to reduce the risk of human exposure.

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