scholarly journals Angiogenic Marker Alterations Following Enamel Matrix Derivative Treatment: A Human Study

2012 ◽  
Vol 2 (1) ◽  
pp. 8
Author(s):  
Onur Özçelik ◽  
Gülşah Seydaoğlu ◽  
Murat Cömert ◽  
Eftal Yılmaz ◽  
M. Cenk Haytaç
Keyword(s):  
Wound Healing ◽  
Inflammatory Infiltrate ◽  
Soft Tissues ◽  
Human Study ◽  
Gingival Tissue ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
And Control ◽  
Angiogenic Marker ◽  
Matrix Derivative

Aim: The aim of this immunohistochemical study was to assess the expression of angiogenic markers (vascular endothelial growth factor (VEGF) and microvessel density (MVD) in enamel matrix derivative (EMD) treated retromolar soft tissues to gain further insights into the biological mechanisms involved in wound healing and EMD treatment. Methodology: In twenty healthy volunteers, gingival biopsies were obtained from the distal wedge operations of test (EMD-applied) and control sites. EMD was applied into the test sites during the operation. At the 15th post-operative day, the sample sites were re-entered and gingival tissue samples were obtained from both test and control sites. A total of 80 samples for each sites were analyzed by immunohistochemistry for inflammatory infiltrate, expression of VEGF and MVD. Results: Despite similar post-operative inflammatory infiltrate, it was found that EMD- applied sites had statistically higher VEGF-A and VEGF-C expression and MVD compared to the controls on the 15th day. (p <0.0001 for each) Conclusions: This study supports that EMD has an angiogenic potential. The findings of this immunohistochemical analysis may help to gain insight into the angiogenic effects of EMD during the early phases of wound healing.  How to cite this article: Özçelik O, Seydaoğlu G, Cömert M, Yılmaz E, Haytaç MC. Angiogenic Marker Alterations Following Enamel Matrix Derivative Treatment: A Human Study. Int Dent Res 2012;2:8-16. Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Proline-Rich Peptide Mimics Effects of Enamel Matrix Derivative on Rat Oral Mucosa Incisional Wound Healing

2015 ◽  
Vol 86 (12) ◽  
pp. 1386-1395 ◽  
Author(s):  
Oscar Villa ◽  
Johan C. Wohlfahrt ◽  
Ibrahimu Mdla ◽  
Christiane Petzold ◽  
Janne E. Reseland ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oral Mucosa ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Peptide Mimics ◽  
Proline Rich Peptide ◽  
Matrix Derivative

Effect of Enamel Matrix Derivative on Periodontal Wound Healing and Regeneration in an Osteoporotic Model

2014 ◽  
Vol 85 (11) ◽  
pp. 1603-1611 ◽  
Author(s):  
Richard J. Miron ◽  
Lingfei Wei ◽  
Shuang Yang ◽  
Oana M. Caluseru ◽  
Anton Sculean ◽  
...  
Keyword(s):  
Wound Healing ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Wound Healing ◽  
Matrix Derivative

Effects of enamel matrix derivative on periodontal wound healing in an inflammatory environment in vitro

2011 ◽  
Vol 38 (5) ◽  
pp. 479-490 ◽  
Author(s):  
Marjan Nokhbehsaim ◽  
Jochen Winter ◽  
Birgit Rath ◽  
Andreas Jäger ◽  
Søren Jepsen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Wound Healing ◽  
Matrix Derivative

Effects of a topical enamel matrix derivative on skin wound healing

2004 ◽  
Vol 12 (1) ◽  
pp. 100-108 ◽  
Author(s):  
Ursula Mirastschuski ◽  
Daniel Konrad ◽  
Eva Lundberg ◽  
Staale Petter Lyngstadaas ◽  
Lars N. Jorgensen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Skin Wound Healing ◽  
Matrix Derivative

scholarly journals The role of surgical flap design (minimally invasive flap vs. extended flap with papilla preservation) on the healing of intrabony defects treated with an enamel matrix derivative: a 12-month two-center randomized controlled clinical trial

2021 ◽  
Author(s):  
Peter Windisch ◽  
Vincenzo Iorio-Siciliano ◽  
Daniel Palkovics ◽  
Luca Ramaglia ◽  
Andrea Blasi ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Minimally Invasive ◽  
Test Group ◽  
Enamel Matrix Derivative ◽  
Control Group ◽  
Enamel Matrix ◽  
Intrabony Defects ◽  
Minimally Invasive Surgical ◽  
And Control ◽  
Matrix Derivative

Abstract Objectives Minimally invasive flap designs have been introduced to enhance blood clot stability and support wound healing. Limited data appear to suggest, that in intrabony defects, better clinical outcomes can be achieved by means of minimally invasive flap compared to more extended flaps. The aim of this study was to evaluate the healing of intrabony defects treated with either minimally invasive surgical flaps or with modified or simplified papilla preservation techniques in conjunction with the application of an enamel matrix derivative (EMD). Materials and methods Forty-seven subjects were randomly assigned to either test (N = 23) or control (N = 24) procedures. In the test group, the intrabony defects were accessed by means of either minimally invasive surgical technique (MIST) or modified minimally invasive surgical technique (M-MIST) according to the defect localization while the defects in the control group were treated with either the modified or simplified papilla preservation (MPP) or the simplified papilla preservation technique (SPP). EMD was used as regenerative material in all defects. The following clinical parameters were recorded at baseline and after 12 months: full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing depths (PD), clinical attachment level (CAL), and gingival recession (GR). Early healing index (EHI) score was assessed in both groups 1 week following the surgery. CAL gain was set as primary outcome. Results After 12 months follow-up, the CAL gain was 4.09 ± 1.68 mm in test group and 3.79 ± 1.67 mm in control group, while the PD reduction was 4.52 ± 1.34 mm and 4.04 ± 1.62 mm for test and control sites. In both groups, a minimal GR increase (0.35 ± 1.11 mm and 0.25 ± 1.03 mm) was noted. No residual PDs ≥ 6 mm were recorded in both groups. CAL gains of 4–5 mm were achieved in 30.4% and in 29.2% of test and control group, respectively. Moreover, CAL gains ≥ 6 mm were recorded in 21.7% of experimental sites and in 20.8% of control sites. No statistically significant differences in any of the evaluated parameters were found between the test and control procedures (P > 0.05). After 1 week post-surgery, a statistically significant difference (P < 0.05) between the groups was found in terms of EHI score. Conclusions Within the limits of this pilot RCT, the results have failed to show any differences in the measured parameters following treatment of intrabony defects with EMD, irrespective of the employed surgical technique. Clinical relevance In intrabony defects, the application of EMD in conjunction with either MIST/M-MIST or M-PPT/SPPT resulted in substantial clinical improvements.

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