Does the Use of Cyclooxygenase Inhibitors Delay Fracture Healing?

10.5580/166c ◽  
2009 ◽  
Vol 6 (2) ◽  
Keyword(s):  
Fracture Healing ◽  
Cyclooxygenase Inhibitors ◽  
Delay Fracture Healing

Does Diabetes Delay Fracture Healing?

1972 ◽  
Vol 82 (1) ◽  
pp. 134???140 ◽  
Author(s):  
LEWIS COZEN
Keyword(s):  
Fracture Healing ◽  
Delay Fracture Healing

scholarly journals Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna

2012 ◽  
Vol 31 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Lisa J. Kidd ◽  
Nick R. Cowling ◽  
Andy C. Wu ◽  
Wendy L. Kelly ◽  
Mark R. Forwood
Keyword(s):  
Fracture Healing ◽  
Stress Fracture ◽  
Cyclooxygenase Inhibitors

scholarly journals NSAIDs do not appear to delay fracture healing

2012 ◽  
Vol 1 (6) ◽  
Keyword(s):  
Fracture Healing ◽  
Delay Fracture Healing

Teriparatide May Accelerate Fracture Healing

2012 ◽  
Vol 45 (1) ◽  
pp. 60
Author(s):  
BRUCE JANCIN
Keyword(s):  
Fracture Healing

Electrical Stimulation Fails to Speed Stress Fracture Healing

2008 ◽  
Vol 7 (2) ◽  
pp. 30
Author(s):  
HEIDI SPLETE
Keyword(s):  
Electrical Stimulation ◽  
Fracture Healing ◽  
Stress Fracture

In silico strategy for the identification of cyclooxygenase inhibitors from the Thai medicinal mixture Prasaplai

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
B Waltenberger ◽  
D Schuster ◽  
S Paramapojn ◽  
W Gritsanapan ◽  
G Wolber ◽  
...  
Keyword(s):  
In Silico ◽  
Cyclooxygenase Inhibitors

Quantitative Imaging of Angiogenesis in Defect Femoral Fracture Healing using 3D Micro- and Nano-CT

2011 ◽  
Vol 183 (S 01) ◽  
Author(s):  
AC Langheinrich ◽  
D Kögelmaier ◽  
K Lips ◽  
V Witt ◽  
S Pacholke ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Femoral Fracture ◽  
Quantitative Imaging

ADP Plays a Key Role in Thrombogenesis in Rats

1988 ◽  
Vol 59 (02) ◽  
pp. 225-230 ◽  
Author(s):  
J P Maffrand ◽  
A Bernat ◽  
D Delebassée ◽  
G Defreyn ◽  
J P Cazenave ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Bleeding Time ◽  
Thrombus Formation ◽  
Vascular Wall ◽  
Cyclooxygenase Inhibitors ◽  
High Dose ◽  
Silk Thread ◽  
Dense Granules ◽  
Prolonged Bleeding Time ◽  
Venous Shunt

SummaryThe relative importance of ADP, arachidonic acid metabolites and serotonin as thrombogenic factors was evaluated in rats by comparing, after oral administration, the effects of two inhibitors of ADP-induced platelet aggregation (ticlopidine and PCR 4099), three cyclo-oxygenase inhibitors (aspirin, triflusal and indobufen) and a selective serotonin 5HT2 receptor antagonist (ketanserin) on platelet aggregation, in four platelet-dependent thrombosis models and on bleeding time. Platelet aggregation induced by ADP and collagen was completely inhibited by ticlopidine and PCR 4099 whereas only the collagen aggregation was reduced by the cyclo-oxygenase inhibitors. Ketanserin or a depletion of platelet serotonin by reserpine did not affect platelet aggregation. Ticlopidine and PCR 4099 greatly prolonged rat tail transection bleeding time. This is probably related to their known ability to inhibit ADP-mediated platelet aggregation. In contrast, the cyclooxygenase inhibitors did not affect bleeding time at all. Reserpine and ketanserin prolonged bleeding time by interfering with the action of serotonin on the vascular wall. Ticlopidine and PCR4099 were very potent antithrombotics in all the models. Aspirin, only at a high dose, inhibited poorly thrombus formation on a silk thread in an arterio-venous shunt, suggesting that the inhibition of cyclo-oxygenase was not responsible. Triflusal was inactive in all models while indobufen slightly reduced thrombus formation in the silk thread and metallic coil models. Ketanserin and reserpine reduced thrombus only in the metallic coil model. Thrombus formation was greatly reduced in fawn-hooded rats, which lack ADP in their platelet dense granules because of a genetic storage pool deficiency. Taken together, the results obtained with the drugs and with the fawn-hooded rats support the concept that ADP plays a key role in thrombogenesis in rats.

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