A Case of Merkel Cell Carcinoma Metastasis to the Head and the Body of the Pancreas

Background:Merkel cell carcinoma is a rare, aggressive, malignant cutaneous tumor of the elderly or immunosuppressed individuals that usually appears on sun-exposed areas of the body. Its pathogenesis is still debated, and, currently, no standardized treatment exists.Objective:To provide a current updated review of the most relevant data concerning the pathogenesis and management of Merkel cell carcinoma.Methods:Using relevant MeSH terms, we performed a review of the literature on these subjects from 1980 to June 2009.Results and Conclusion:The current management of Merkel cell carcinoma is based on surgical excision as the majority of patients present with localized disease, whereas up to 30% have regional lymph node metastases. In these cases, the best outcome is achieved with multidisciplinary management that includes radiotherapy. Chemotherapy is part of the treatment in advanced cases and is mandatory for distant metastatis. Given that a recent work showed the presence of a previously unknown polyomavirus, which the authors called Merkel cell polyomavirus, the therapeutical approach to Merkel cell carcinoma could be reconsidered in the future.

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Merkel Cell Carcinoma - A Rare Form of Skin Cancer with New Therapeutic Options

Revista de Chimie ◽

10.37358/rc.19.9.7527 ◽

2019 ◽

Vol 70 (9) ◽

pp. 3245-3249

Author(s):

Dana Lucia Stanculeanu ◽

Oana Toma ◽

Cristian Vasile ◽

Cornelia Nitipir ◽

Alina Bodilcu ◽

...

Keyword(s):

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Regional Lymph Node ◽

Performance Status ◽

Lymph Node Involvement ◽

The Body ◽

Therapeutic Options ◽

Merkel Cell ◽

Node Involvement ◽

And Performance

Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma of the skin, with very aggressive behavior. Etiological factors contributing to MCC development, include exposure to UV radiation, infection with Merkel cell polyomavirus (MCPyV) and chronic immunosuppression. It is commonly found in regions of the body that are exposed to sun -55% of cases are located in the head and neck. The 5 years survival rate for metastatic disease is approximately 25%. The estimated mortality rate for MCC is between 33% and 46%. Therapeutic options for MCC depends on disease characteristics (stage of disease at presentation, location of the tumor, regional lymph node involvement, comorbidities and performance status of the patient) and it includes multimodal treatments like surgery, chemotherapy and emerging immunotherapeutic treatments with early promising results. Our clinic experience is very limited with this type of malignancy, only three cases were diagnosed and treated in our department, but with encouraging results regarding the newest immunotherapeutic options, with good quality of life and results similar with the data from the literature.

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A Rare Case of Merkel Cell Carcinoma Metastasis to the Adrenal Resected Robotically

Surgical Laparoscopy Endoscopy & Percutaneous Techniques ◽

10.1097/sle.0b013e31827479a1 ◽

2013 ◽

Vol 23 (1) ◽

pp. e35-e37 ◽

Cited By ~ 3

Author(s):

Ziyad Alguraan ◽

Orhan Agcaoglu ◽

Shamil Aliyev ◽

Eren Berber

Keyword(s):

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Rare Case ◽

Merkel Cell ◽

Carcinoma Metastasis

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Metastatic Merkel cell carcinoma and malignant melanoma in a single sentinel lymph node

SAGE Open Medical Case Reports ◽

10.1177/2050313x211023685 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110236

Author(s):

Amanda Hamilton ◽

Prasad Jayaratne ◽

Mark Zonta

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Malignant Melanoma ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Lymph Node Biopsy ◽

The Body ◽

Ageing Population ◽

Merkel Cell ◽

Dual Diagnoses

Merkel cell carcinoma (MCC) and malignant melanoma are aggressive skin cancers that usually arise in sun-exposed parts of the body. This report describes an 85-year-old man who underwent a wide local excision and sentinel lymph node biopsy for primary MCC and was subsequently found to have metastatic MCC and malignant melanoma within the left inguinal sentinel lymph node. Dual diagnoses of aggressive cutaneous carcinomas, although rare, may become more common in regions of high ultraviolet exposure and an ageing population. Currently, there are no guidelines for treating synchronous MCC and melanoma, however, immunotherapy with PD-1 inhibitors and anti-CTLA-4 receptor antagonists have shown therapeutic effect against these two cancers and should be considered in treatment planning.

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