scholarly journals Generic selection criteria for safety and patient benefit [V]: Comparing the pharmaceutical properties and patient usability of original and generic nasal spray containing ketotifen fumarate

2016 ◽  
Vol 10 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Yuko Wada ◽  
Shyoko Ami ◽  
Mitsuru Nozawa ◽  
Miho Goto ◽  
Ken-ichi Shimokawa ◽  
...  
Keyword(s):  
Nasal Spray ◽  
Selection Criteria ◽  
Patient Benefit ◽  
Ketotifen Fumarate ◽  
Pharmaceutical Properties

scholarly journals Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1719 ◽  
Author(s):  
Deepak Gupta ◽  
Deepak Bhatia ◽  
Vivek Dave ◽  
Vijaykumar Sutariya ◽  
Sheeba Varghese Gupta
Keyword(s):  
Selection Criteria ◽  
Opposite Effect ◽  
Biological Properties ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Salt Form ◽  
Pharmaceutical Ingredients ◽  
Selection Processes ◽  
Salt Selection ◽  
Pharmaceutical Properties ◽  
Salt Forms

The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes.

scholarly journals Generic Selection Criteria for Safety and Patient Benefit [III]

2015 ◽  
Vol 41 (6) ◽  
pp. 394-403 ◽  
Author(s):  
Yuko Wada ◽  
Mitsuru Nozawa ◽  
Miho Goto ◽  
Ken-ichi Shimokawa ◽  
Fumiyoshi Ishii
Keyword(s):  
Selection Criteria ◽  
Patient Benefit
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