Dry Mouth Symptoms and QOL after Radiation Treatment in Head and Neck Cancer Patients

2017 ◽  
Vol 149 (0) ◽  
pp. 220-226
Author(s):  
Masako Uno ◽  
Yukiyoshi Hyo ◽  
Tamotsu Harada
2019 ◽  
Vol 28 (6) ◽  
pp. 2817-2828 ◽  
Author(s):  
Sumalee Nuchit ◽  
Aroonwan Lam-ubol ◽  
Wannaporn Paemuang ◽  
Sineepat Talungchit ◽  
Orapin Chokchaitam ◽  
...  

Abstract Purpose The aim of this study is to investigate the effect of an edible saliva substitute, oral moisturizing jelly (OMJ), and a topical saliva gel (GC) on dry mouth, swallowing ability, and nutritional status in post-radiotherapy head and neck cancer patients. Methods Sixty-two post-radiation head and neck cancer patients with xerostomia completed a blinded randomized controlled trial. They were advised to swallow OMJ (n = 31) or apply GC orally (n = 31) for 2 months. Outcome measures were assessed at baseline, 1, and 2 months, including subjective and objective dry mouth (Challcombe) scores, subjective swallowing problem scores (EAT-10), water swallowing time, clinical nutritional status (PG-SGA), body weight, and dietary intake. Results After 1 and 2 months of interventions, subjective and objective dry mouth scores, subjective swallowing problem scores, swallowing times, and clinical nutritional status in both groups were significantly improved (p < 0.0001). Compared to GC, OMJ group had higher percent improvement in all outcome measures (p < 0.001) except swallowing time and clinical nutritional status. Interestingly, subjective dry mouth scores were significantly correlated with subjective swallowing problem scores (r = 0.5321, p < 0.0001). Conclusions Continuous uses of saliva substitutes (OMJ or GC) for at least a month improved signs and symptoms of dry mouth and enhanced swallowing ability. An edible saliva substitute was superior to a topical saliva gel for alleviating dry mouth and swallow problems. These lead to improved clinical nutritional status. Thus, palliation of dry mouth may be critical to support nutrition of post-radiotherapy head and neck cancer patients. Clinical trial registry Clinicaltrials.gov NCT03035825


2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 6063-6063 ◽  
Author(s):  
Susan K. Peterson ◽  
Adam S. Garden ◽  
Eileen H. Shinn ◽  
Sanjay Shete ◽  
Stephanie L. Martch ◽  
...  

2015 ◽  
Vol 24 (5) ◽  
pp. 2101-2109 ◽  
Author(s):  
Simon Lønbro ◽  
Gry Bjerg Petersen ◽  
Jens Rikardt Andersen ◽  
Jørgen Johansen

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