scholarly journals SEAMLESS PHASE II/III CLINICAL TRIALS WITH COVARIATE ADAPTIVE RANDOMIZATION

2022 ◽  
Author(s):  
Wei Ma ◽  
Mengxi Wang ◽  
Hongjian Zhu
Keyword(s):  
Clinical Trials ◽  
Phase Ii ◽  
Adaptive Randomization

scholarly journals Response adaptive randomization procedures in seamless phase II/III clinical trials

2019 ◽  
Vol 30 (1) ◽  
pp. 3-17
Author(s):  
Hongjian Zhu ◽  
Jin Piao ◽  
J. Jack Lee ◽  
Feifang Hu ◽  
Lixin Zhang
Keyword(s):  
Clinical Trials ◽  
Phase Ii ◽  
Adaptive Randomization

Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

2020 ◽  
Vol 20 (19) ◽  
pp. 2019-2035
Author(s):  
Esmaeil Sheikh Ahmadi ◽  
Amir Tajbakhsh ◽  
Milad Iranshahy ◽  
Javad Asili ◽  
Nadine Kretschmer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activity ◽  
Small Molecules ◽  
Anticancer Activity ◽  
Clinical Significance ◽  
Phase Ii ◽  
Biological Activities ◽  
Phase Ii Clinical Trials ◽  
Naturally Occurring ◽  
The Subject

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

scholarly journals Ixabepilone-associated peripheral neuropathy: data from across the phase II and III clinical trials

2012 ◽  
Vol 20 (11) ◽  
pp. 2661-2668 ◽  
Author(s):  
Linda T. Vahdat ◽  
Eva S. Thomas ◽  
Henri H. Roché ◽  
Gabriel N. Hortobagyi ◽  
Joseph A. Sparano ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Peripheral Neuropathy ◽  
Phase Ii ◽  
Phase Ii And Iii

scholarly journals Brief Report: A Phase II Study of Sunitinib in Malignant Pleural Mesothelioma. The NCIC Clinical Trials Group

2011 ◽  
Vol 6 (11) ◽  
pp. 1950-1954 ◽  
Author(s):  
Scott A. Laurie ◽  
Ashish Gupta ◽  
Quincy Chu ◽  
Christopher W. Lee ◽  
Wojciech Morzycki ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Phase Ii ◽  
Malignant Pleural Mesothelioma ◽  
Phase Ii Study ◽  
Pleural Mesothelioma
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