scholarly journals Measles Virus Infection: Mechanisms of Immune Suppression

10.5772/29662 ◽  
2012 ◽  
Author(s):  
Xuelian Yu ◽  
Reena Ghildyal
Keyword(s):  
Virus Infection ◽  
Immune Suppression ◽  
Measles Virus ◽  
Infection Mechanisms

scholarly journals Cytokine Imbalance after Measles Virus Infection Has No Correlation with Immune Suppression

2009 ◽  
Vol 83 (14) ◽  
pp. 7244-7251 ◽  
Author(s):  
Mary Carsillo ◽  
Kay Klapproth ◽  
Stefan Niewiesk
Keyword(s):  
Virus Infection ◽  
Immune Suppression ◽  
Recombinant Virus ◽  
Measles Virus ◽  
Vaccine Virus ◽  
Gamma Interferon ◽  
Wild Type Virus ◽  
Wild Type ◽  
Spleen Cells ◽  
Th2 Response

ABSTRACT Measles virus infection leads to immune suppression. A potential mechanism is the reduction of interleukin 12 (IL-12) secretion during acute measles, resulting in a TH2 response. Studies in humans have reported conflicting results, detecting either a TH2 or a TH1 response. We have investigated the correlation between a TH2 response and immune suppression in specific-pathogen-free inbred cotton rats which were infected with measles vaccine and wild-type viruses. After infection of bone marrow-derived macrophages with wild-type virus, IL-12 secretion was reduced in contrast to the level for vaccine virus infection. In bronchoalveolar lavage cells, IL-12 secretion was suppressed after infection with both wild-type and vaccine virus on days 2, 4, and 6 and was detectable on days 8 and 10. After stimulation of mediastinal lymph node and spleen cells with UV-inactivated measles virus at various time points after infection, gamma interferon but no IL-4 was found. After stimulation with phorbol myristate acetate-ionomycin, high gamma interferon and low IL-4 levels were detected. To investigate whether the secretion of IL-4 contributes to immune suppression, a recombinant vaccine virus was created which secretes cotton rat IL-4. After infection with this recombinant virus, IL-4 secretion was enhanced. However, neither inhibition of concanavalin A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of spleen cells was altered after infection with the recombinant virus in comparison to the levels with the parental virus. Our data indicate that measles virus infection leads to a decrease in IL-12 secretion and an increase in IL-4 secretion, but this does not seem to correlate with immune suppression.

CD8+CD57+ lymphocytes in blood of children after measles virus infection

1997 ◽  
Vol 56 (1-3) ◽  
pp. 297
Author(s):  
B Aronsson
Keyword(s):  
Virus Infection ◽  
Measles Virus

Improvement of food-sensitive atopic dermatitis accompanied by reduced lymphocyte responses to food antigen following natural measles virus infection

1993 ◽  
Vol 23 (1) ◽  
pp. 44-50 ◽  
Author(s):  
N. KONDO ◽  
O. FUKUTOMI ◽  
T. OZAWA ◽  
H. AGATA ◽  
T. KAMEYAMA ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Virus Infection ◽  
Measles Virus ◽  
Food Antigen ◽  
Lymphocyte Responses

Measles virus infection in cultured normal human oral epithelium cells

1997 ◽  
Vol 26 ◽  
pp. 248
Author(s):  
T. Oomata ◽  
K. Miyamoto ◽  
Y. Buyo ◽  
T. Wada ◽  
N. Morita ◽  
...  
Keyword(s):  
Virus Infection ◽  
Measles Virus ◽  
Oral Epithelium ◽  
Normal Human ◽  
Epithelium Cells

Acute infectious mononucleosis and coincidental measles virus infection

2004 ◽  
Vol 31 (2) ◽  
pp. 160-164 ◽  
Author(s):  
A.V. Atrasheuskaya ◽  
S.N. Kameneva ◽  
A.A. Neverov ◽  
G.M. Ignatyev
Keyword(s):  
Virus Infection ◽  
Infectious Mononucleosis ◽  
Measles Virus ◽  
Acute Infectious Mononucleosis

scholarly journals Mechanisms of Measles Virus-Induced Immune Suppression in the Cotton Rat Model

2010 ◽  
Vol 30 (6) ◽  
pp. 455-460
Author(s):  
Mary Elizabeth Carsillo
Keyword(s):  
Rat Model ◽  
Immune Suppression ◽  
Measles Virus ◽  
Cotton Rat

Enhanced detection of measles virus infection following successful development of a real-time reverse transcriptase PCR in respiratory and urine samples using the cepheid SmartCycler®

Pathology ◽  
2015 ◽  
Vol 47 ◽  
pp. S57
Author(s):  
Kyra Y.L. Chua ◽  
Kiran Thapa ◽  
Chaturangi M. Yapa ◽  
Lucy K. Somerville ◽  
Vicky Sheppeard ◽  
...  
Keyword(s):  
Virus Infection ◽  
Reverse Transcriptase ◽  
Real Time ◽  
Measles Virus ◽  
Urine Samples ◽  
Successful Development ◽  
Reverse Transcriptase Pcr

Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells

FEBS Letters ◽  
1989 ◽  
Vol 250 (2) ◽  
pp. 367-370 ◽  
Author(s):  
M. Wolfson ◽  
A. Katorza ◽  
S. Segal ◽  
B. Rager-Zisman
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Virus Infection ◽  
Measles Virus ◽  
Neuroblastoma Cells ◽  
Kinase C ◽  
Protein Kinase C Activity

scholarly journals Subacute Sclerosing Panencephalitis

2019 ◽  
Vol 37 (4) ◽  
pp. 205-208
Author(s):  
Gobinda Chandra Banik ◽  
Sakib Aman ◽  
Farhana Sultana ◽  
Syed Mohammad Arif
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Antibody Titer ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Abnormal Behavior ◽  
Short History ◽  
Altered Consciousness ◽  
History Of ◽  
Metachromatic Leucodystrophy

  Subacute sclerosing panencephalitis (SSPE) is chronic progressive encephalitis of childhood and young adoloscent due to persistent measles virus infection. This case illustrates a 14 year old girl presented with short history of intellectual decline, abnormal behavior, myoclonus and altered consciousness with suggestive neuroimaging mimicking metachromatic leucodystrophy. Subsequently she was diagnosed to be a case of Subacute sclerosing panencephalitis (SSPE) on the basis of Electroencephalography (EEG) and Cerebrospinal fluid(CSF) measles antibody titer. J Bangladesh Coll Phys Surg 2019; 37(4): 205-208

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