scholarly journals Fibrinolytic Enzymes from Medicinal Mushrooms

10.5772/38221 ◽  
2012 ◽  
Author(s):  
Chung-Lun Lu ◽  
Shiu-Nan Che

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Chamiolo ◽  
D Oehrke ◽  
K Schmidt ◽  
K Bensch ◽  
J Tiralongo ◽  
...  


1997 ◽  
Vol 77 (05) ◽  
pp. 0959-0963 ◽  
Author(s):  
Lisa Seale ◽  
Sarah Finney ◽  
Roy T Sawyer ◽  
Robert B Wallis

SummaryTridegin is a potent inhibitor of factor Xllla from the leech, Haementeria ghilianii, which inhibits protein cross-linking. It modifies plasmin-mediated fibrin degradation as shown by the absence of D-dimer and approximately halves the time for fibrinolysis. Plasma clots formed in the presence of Tridegin lyse more rapidly when either streptokinase, tissue plasminogen activator or hementin is added 2 h after clot formation. The effect of Tridegin is markedly increased if clots are formed from platelet-rich plasma. Platelet-rich plasma clots are lysed much more slowly by the fibrinolytic enzymes used and if Tridegin is present, the rate of lysis returns almost to that of platelet- free clots. These studies indicate the important role of platelets in conferring resistance to commonly used fibrinolytic enzymes and suggest that protein cross-linking is an important step in this effect. Moreover they indicate that Tridegin, a small polypeptide, may have potential as an adjunct to thrombolytic therapy.



2020 ◽  
Vol 22 (12) ◽  
pp. 1191-1201
Author(s):  
Ying Yang ◽  
Ning Bu ◽  
Shenghou Wang ◽  
Jiaojiao Zhang ◽  
Ying Wang ◽  
...  




2000 ◽  
Vol 2 (1) ◽  
pp. 4 ◽  
Author(s):  
Victor V. Scherba ◽  
Nadezda Yu. Mitropolskaya ◽  
Nina A. Bisko
Keyword(s):  


2003 ◽  
Vol 5 (1) ◽  
pp. 61-86 ◽  
Author(s):  
Solomon P. Wasser ◽  
Anna A. Grodzinskaya ◽  
Michael Berreck ◽  
Kurt Haselwandter
Keyword(s):  


2019 ◽  
Vol 21 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Adam Brezáni ◽  
Katerina Svobodova ◽  
Ivan Jablonský ◽  
Pavel Tlustoš


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