scholarly journals Primary Intraocular Lymphoma: The Masquerade Syndrome

2021 ◽  
Author(s):  
Lupi Alessandro ◽  
Iaccheri Barbara ◽  
Tucci Davide ◽  
Cagini Carlo ◽  
Fiore Tito
Keyword(s):  
Correct Diagnosis ◽  
Rare Condition ◽  
Intraocular Lymphoma ◽  
Reticulum Cell ◽  
Primary Intraocular Lymphoma ◽  
Central System ◽  
Specific Proteins ◽  
Masquerade Syndrome ◽  
Delays In Diagnosis ◽  
Specific Symptoms

This chapter aims to provide a complete knowledge over the primary intraocular lymphoma (PIOL) and a correct clinical approach towards this rare condition, to avoid delays in diagnosis, which is considered the most important prognostic factor. A PIOL arises with no specific symptoms and could mimic both inflammatory and non-inflammatory ocular conditions. Also known as reticulum cell sarcoma in the past, PIOL is an ocular malignant condition, with a strong bond with primary central system lymphoma (PCNSL). This linkage is underlined by the fact that approximately 30% of the patients with PIOL have also PCNSL at presentation, while 45–90% will develop PCSNL in the following months. A correct diagnosis is currently achieved by the means of many different techniques: cytology, flow cytometry, immunohistochemistry, molecular analysis, and cytokines assay. Treatment of this condition has been completely revolutionized with the introduction of monoclonal antibodies directed against specific proteins present on the surface of lymphomatous cells.

Primary Intraocular Lymphoma (ocular reticulum cell sarcoma) Diagnosis and Management

Ophthalmology ◽  
1988 ◽  
Vol 95 (5) ◽  
pp. 625-630 ◽  
Author(s):  
Devron H. Char ◽  
Britt-Marie Ljung ◽  
Theodore Miller ◽  
Theodore Phillips
Keyword(s):  
Intraocular Lymphoma ◽  
Reticulum Cell ◽  
Primary Intraocular Lymphoma ◽  
Reticulum Cell Sarcoma ◽  
Cell Sarcoma ◽  
Diagnosis And Management

Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome

2003 ◽  
Vol 241 (10) ◽  
pp. 860-870 ◽  
Author(s):  
Sarah E. Coupland ◽  
Nikolaos E. Bechrakis ◽  
Gerasimos Anastassiou ◽  
Andreas M. H. Foerster ◽  
Arnd Heiligenhaus ◽  
...  
Keyword(s):  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma ◽  
Masquerade Syndrome

Bone marrow necrosis and fat embolism syndrome: a near fatal complication in previously undiagnosed sickle beta + thalassaemia

2021 ◽  
Vol 14 (1) ◽  
pp. e238317
Author(s):  
Nibash Budhathoki ◽  
Sunita Timilsina ◽  
Bebu Ram ◽  
Douglas Marks
Keyword(s):  
Bone Marrow ◽  
Multiorgan Failure ◽  
Rare Condition ◽  
Altered Mental Status ◽  
Fat Embolism ◽  
Bone Marrow Necrosis ◽  
Embolism Syndrome ◽  
Hb S ◽  
High Index Of Suspicion ◽  
Specific Symptoms

Prevalence of haemoglobin sickle-β+ thalassaemia (Hb S/β+thal) is variable with geography ranging from 0.2% to 10% among sickle cell patients. Clinical presentation of Hb S/β+thal patients depends on HbA level, with milder disease often going undiagnosed. However, rarely these patients can present with a fulminant vaso-occlusive crisis (VOC). Given VOC can present with non-specific symptoms, the diagnosis and treatment is often delayed. Here, we present a patient who initially developed altered mental status, pancytopenia and multiorgan failure due a critical VOC resulting in bone marrow necrosis and fat embolism. Subsequent workup confirmed that our patient had Sickle-β+ thalassaemia, which had gone undiagnosed, despite subclinical evidence of haemolysis on routine lab work for years. Following diagnosis and initiation of RBC exchange, he improved significantly and was discharged home. High index of suspicion and bone marrow biopsy is vital for early diagnosis and management of this rare condition.

scholarly journals Next-generation protein analysis in the pathology department

2019 ◽  
Vol 73 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Melek Ahmed ◽  
Glenn Broeckx ◽  
Geert Baggerman ◽  
Karin Schildermans ◽  
Patrick Pauwels ◽  
...  
Keyword(s):  
Personalised Medicine ◽  
Correct Diagnosis ◽  
Mrna Level ◽  
Imaging Mass Spectrometry ◽  
Tissue Analysis ◽  
Therapeutic Decision ◽  
Promising Technique ◽  
Maldi Ims ◽  
Specific Proteins ◽  
Molecular Information

Traditionally, immunohistochemistry (IHC) is used by pathologists to localise specific proteins or peptides in tissue slides. In the era of personalised medicine, however, molecular tissue analysis becomes indispensable for correct diagnosis, prognosis and therapeutic decision, not only on the DNA or mRNA level but also on the protein level. Combining molecular information with imaging presents many advantages. Therefore, matrix-assisted laser desorption/ionisation imaging mass spectrometry (MALDI IMS) is a promising technique to be added to the armamentarium of the pathologist. Here, we focus on the workflow, advantages and drawbacks of both MALDI IMS and IHC. We also briefly discuss a few other protein imaging modalities and give examples of applications.

Iris Involvement in Primary Intraocular Lymphoma

2000 ◽  
Vol 44 (6) ◽  
pp. 518-526 ◽  
Author(s):  
Gisela Velez ◽  
Marc D de Smet ◽  
Scott M Whitcup ◽  
Michael Robinson ◽  
Robert B Nussenblatt ◽  
...  
Keyword(s):  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma

OCULAR SARCOIDOSIS MISDIAGNOSED AS PRIMARY INTRAOCULAR LYMPHOMA

Retina ◽  
2010 ◽  
Vol 30 (2) ◽  
pp. 310-316 ◽  
Author(s):  
ANDREA D. BIRNBAUM ◽  
WENDY HUANG ◽  
OZLEM SAHIN ◽  
HOWARD H. TESSLER ◽  
DEBRA A. GOLDSTEIN
Keyword(s):  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma ◽  
Ocular Sarcoidosis

Su.127. Eradication of Tumor Colonization and Invasion By a B-Cell Specific Immunotoxin in a Murine Model for Human Primary Intraocular Lymphoma (Piol)

2006 ◽  
Vol 119 ◽  
pp. S203
Author(s):  
Zhuqing Li ◽  
Mahesh Sankaranarayana ◽  
Baoying Liu ◽  
Chi-Chao Chan ◽  
DeFeng Shen ◽  
...  
Keyword(s):  
B Cell ◽  
Murine Model ◽  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma

scholarly journals Rete Middle Cerebral Artery Anomaly Presenting with a Large Intracerebral Hemorrhage: A Case Report

2021 ◽  
Author(s):  
Chandra Dev Sahu ◽  
Nishant Bhargava ◽  
Debabrata Sahana ◽  
Sanjeev Kumar
Keyword(s):  
Case Report ◽  
High Risk ◽  
Intracerebral Hemorrhage ◽  
Middle Cerebral Artery ◽  
Single Channel ◽  
Correct Diagnosis ◽  
Rare Condition ◽  
Haemorrhagic Stroke ◽  
Unilateral Involvement ◽  
Is Failure

AbstractRete MCA anomaly is extremely rare and has been seldomly discussed in literature. Embryologically MCA develops by fusion of multiple twigs which form a single channel. If there is failure to fuse a plexiform network of vessels persists known as rete MCA. This web like network of vessels is at high risk of haemorrhagic stroke and therefore for patients presenting incidentally correct diagnosis is paramount. Here we report a case of rete MCA anomaly in a 35-year-old gentle man who presented with a large haemorrhagic stroke in emergency. DSA showed unilateral involvement of proximal MCA, and otherwise normal intra-cranial vasculature. With this report we aim to correctly diagnose this rare condition and avoid misdiagnosis leading to unnecessary treatments.

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