scholarly journals Parathyroid Scintigraphy

2021 ◽  
Author(s):  
Albena Dimitrova Botushanova ◽  
Nikolay Petrov Botushanov
Keyword(s):  
Single Photon ◽  
Imaging Modality ◽  
Photon Emission ◽  
Dual Isotope ◽  
Sestamibi Scintigraphy ◽  
99Mtc Tetrofosmin ◽  
Positron Emission ◽  
Single Photon Emission Ct ◽  
Parathyroid Adenomas ◽  
99Mtc Sestamibi

The visualization of abnormal parathyroid glands is difficult due to their variations in number and localization. Noninvasive parathyroid imaging studies include 99mTc-sestamibi scintigraphy, ultrasonography, computed tomography scanning, magnetic resonance imaging, and positron emission tomography. There is a general consensus that the most sensitive and specific imaging modality, especially when it is combined with single-photon emission CT is the scintigraphy with 99mTc-sestamibi or 99mTc-tetrofosmin. 99mTc-sestamibi scintigraphy significantly increases the role of preoperative scintigraphy in patients with hyperparathyroidism and allows unilateral surgical approach with minimally invasive parathyroidectomy to be used. Generally, three protocols with the use of two radiopharmaceuticals, 99mTc-sestamibi or 99mTc-tetrofosmin, are most widely applied: single-phase dual-isotope subtraction, dual-phase single-isotope and combination of both. Each one of them has specific advantages and disadvantages. While single parathyroid adenomas are localized with greater precision, hyperfunctioning parathyroid hyperplastic cells represent a real challenge to the imaging modalities. Several factors can influence the radionuclide uptake in pathologically changed parathyroid cells, like the size, the level of their functional activity, the quantity of oxyphilic cells, mitochondria, P glycoprotein and other MDR gene products.

scholarly journals MEASUREMENT OF YTTRIUM-90 BIODISTRIBUTION IN SELECTIVE INTERNAL RADIATION THERAPY (SIRT)

2019 ◽  
Vol 4 (2) ◽  
pp. 45-57
Author(s):  
Sita Gandes Pinasti
Keyword(s):  
Single Photon ◽  
Imaging Modality ◽  
Photon Emission ◽  
Absorbed Dose ◽  
Emission Tomography ◽  
Response Analysis ◽  
Dose Estimation ◽  
Positron Emission ◽  
Healthy Liver

Measurement of radionuclides biodistribution in post-radioembolization 90Y SIRT is a part of treatment evaluation, in which the assessment of biodistribution is used to evaluate the possible extrahepatic presence and the absorbed dose estimation for the tumor cells, healthy liver cells, and critical organs. As the dose-response analysis is performed based on this evaluation, the biodistribution measurement coming from post-imaging modality has a crucial role in achieving these goals. The two devices, Single Photon Emission Tomography (SPECT) and Positron Emission Tomography are discussed in some aspects, including the quality of quantitative images, performance characteristics, and absorbed dose considerations.

scholarly journals Cardiac PET-CT: A Brief Review of Indications and Feasibility in the Indian Scenario

2020 ◽  
Vol 5 (02) ◽  
pp. 129-136
Author(s):  
Kavitha Nallapareddy ◽  
V. L. Gowthami Rayaprolu
Keyword(s):  
Single Photon ◽  
Imaging Modality ◽  
Photon Emission ◽  
Myocardial Inflammation ◽  
Emission Computed Tomography ◽  
Cardiac Positron Emission Tomography ◽  
Positron Emission ◽  
Perfusion Agents ◽  
Perfusion Assessment ◽  
Positron Emitters

AbstractCardiac positron emission tomography (PET) is a functional imaging modality with the predominant indications being an assessment of myocardial perfusion and viability using short-lived positron emitters. PET procedures are used for perfusion assessment only when single-photon emission computed tomography is equivocal. Perfusion agents are ultra short-lived and have limited availability in our country, that is, only at centers with onsite cyclotron. Viability assessment with fluorodeoxyglucose (FDG) is widely performed in many centers across the country due to the availability of FDG. The other important indication is in the detection of inflammatory myocarditis, the most common being cardiac sarcoidosis done with special dietary instructions and FDG as a tracer. This indication is widely used for early detection of myocardial inflammation which would be reversible if treated early. It is also used in the assessment of treatment response. Newer tracer 68 Ga Dotapeptide is also used in this application.

SINGLE PHOTON EMISSION CT AND POSITRON EMISSION TOMOGRAPHY IN THE EVALUATION OF NEUROLOGIC DISEASE

2001 ◽  
Vol 39 (5) ◽  
pp. 1007-1033 ◽  
Author(s):  
Ronald L. Van Heertum ◽  
Charles Drocea ◽  
Masanori Ichise ◽  
Kyriakos Lobotesis ◽  
Rashid A. Fawwaz
Keyword(s):  
Positron Emission Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Neurologic Disease ◽  
Single Photon Emission ◽  
Positron Emission ◽  
Single Photon Emission Ct

99mTc Tetrofosmin Uptake in Lung Cancer

1996 ◽  
Vol 37 (3P2) ◽  
pp. 763-766 ◽  
Author(s):  
M. Ishibashi ◽  
A. Hayashi ◽  
S. Takamori ◽  
H. Ohzono ◽  
S. Morita ◽  
...  
Keyword(s):  
Lung Tumor ◽  
Single Photon ◽  
Photon Emission ◽  
Myocardial Imaging ◽  
Single Photon Emission ◽  
Focal Uptake ◽  
99Mtc Tetrofosmin ◽  
Single Photon Emission Ct ◽  
Inferior Segment ◽  
The Right

This case report describes a 71-year-old man with a lung tumor in the posterior inferior segment of the right lung, detected on a screening chest radiograph. The patient underwent myocardial imaging with 99mTc tetrofosmin and 201Tl, using single photon emission CT (SPECT), and the tumor showed intense focal uptake of the radiotracer. This observation supports the recent suggestion that 99mTc tetrofosmin may be useful for oncologic imaging of lung carcinoma, and further studies may be warranted.

scholarly journals Diagnostic Impact of 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and White Blood Cell SPECT/Computed Tomography in Patients With Suspected Cardiac Implantable Electronic Device Chronic Infection

2019 ◽  
Vol 12 (7) ◽  
Author(s):  
Jérémie Calais ◽  
Aziza Touati ◽  
Nathalie Grall ◽  
Cédric Laouénan ◽  
Khadija Benali ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Cell ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Single Photon Emission ◽  
Positron Emission ◽  
Single Photon Emission Ct ◽  
Fluorodeoxyglucose Positron Emission

Background: Cardiac implantable electronic devices (CIEDs) chronic infection diagnosis is challenging because the clinical presentation is frequently misleading and echocardiography may be inconclusive. The aim of this study was to evaluate the diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (CT) and radiolabeled white blood cells single photon emission CT/CT in a cohort of patients who underwent both scans for suspicion of CIED infection and inconclusive routine investigations. Methods: Forty-eight consecutive patients with suspicion of CIED infection who underwent both 18 F-fluorodeoxyglucose positron emission tomography/CT and white blood cell single photon emission CT/CT in a time span ≤30 days were retrospectively included. The final diagnosis of CIED infection by the endocarditis expert team was based on the modified Duke-Li classification at the end of follow-up. 18 F-Fluorodeoxyglucose positron emission tomography/CT and white blood cell single photon emission CT/CT scans were independently analyzed blinded to the patients’ medical record. Results: In the overall study population, the diagnostic sensitivity, specificity, positive predictive value, and negative predictive value were respectively 80%, 91%, 80%, and 91% for 18 F-fluorodeoxyglucose positron emission tomography/CT and 60%, 100%, 100%, and 85% for white blood cell single photon emission CT/CT. Addition of a positive nuclear imaging scan as a major criterion markedly improved the Duke-Li classification at admission. Semiquantitative parameters did not allow to discriminate between definite and rejected CIED infection. Prolonged antibiotic therapy before imaging tended to decrease the sensitivity for both techniques. Conclusions: Nuclear imaging can improve the diagnostic performances of the Duke-Li score at admission in a selected population of patients with suspected CIED infection, particularly when the infection was initially graded as possible. Whenever possible, imaging should be performed before or early after antibiotic initiation.

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