A case of acquired hemophilia A in a patient with prostate cancer and medication-related osteonecrosis of the jaw

Acquired Hemophilia A (AHA) is a rare bleeding diathesis characterized by the development of autoantibodies against factor VIII (FVIII). About half of the cases are idiopathic and the other half are associated with autoimmune diseases, postpartum problems, infections, inflammatory bowel disease, drugs, lymphoproliferative disorders or solid tumors . AHA is associated with malignancies in 7-15% of cases. We report a case of AHA in a 65 year old patient with prostatic carcinoma, who underwent retropubic radical prostatectomy (RP).

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Life-threatening hemorrhage from acquired hemophilia A as a presenting manifestation of prostate cancer

Journal of Community Hospital Internal Medicine Perspectives ◽

10.3402/jchimp.v6.32461 ◽

2016 ◽

Vol 6 (4) ◽

pp. 32461 ◽

Cited By ~ 2

Author(s):

Chirag Sheth ◽

Amandeep Gill ◽

Sumeet Sekhon

Keyword(s):

Prostate Cancer ◽

Hemophilia A ◽

Acquired Hemophilia A ◽

Acquired Hemophilia ◽

Life Threatening

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Acquired hemophilia A in a patient with advanced prostate cancer

Autopsy and Case Reports ◽

10.4322/acr.2015.008 ◽

2015 ◽

Vol 5 (2) ◽

pp. 45-48 ◽

Cited By ~ 1

Author(s):

Daniel da Motta Girardi ◽

Douglas Rafael Almeida Silva ◽

Paula Ribeiro Villaça ◽

Ciro Eduardo Souza ◽

Leonardo Gomes da Fonseca ◽

...

Keyword(s):

Prostate Cancer ◽

Advanced Prostate Cancer ◽

Hemophilia A ◽

Acquired Hemophilia A ◽

Acquired Hemophilia

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Case – Acquired hemophilia A in a patient with metastatic castration-resistant prostate cancer

Canadian Urological Association Journal ◽

10.5489/cuaj.7089 ◽

2021 ◽

Vol 15 (9) ◽

Author(s):

Michael Poscente ◽

Chun Loo Gan ◽

Daniel Y.C. Heng ◽

Nimira Alimohamed

Keyword(s):

Prostate Cancer ◽

Hemophilia A ◽

Castration Resistant Prostate Cancer ◽

Acquired Hemophilia A ◽

Acquired Hemophilia ◽

Castration Resistant

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Successful Management of Acquired Hemophilia A Associated with Bullous Pemphigoid: A Case Report and Review of the Literature

Case Reports in Hematology ◽

10.1155/2017/2057019 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Quentin Binet ◽

Catherine Lambert ◽

Laurine Sacré ◽

Stéphane Eeckhoudt ◽

Cedric Hermans

Keyword(s):

Bullous Pemphigoid ◽

Neutralizing Antibodies ◽

Hemophilia A ◽

Rare Condition ◽

Term Treatment ◽

Acquired Hemophilia A ◽

Acquired Hemophilia ◽

Short Term Treatment ◽

Life Threatening ◽

Dose Levels

Background. Acquired hemophilia A (AHA) is a rare condition, due to the spontaneous formation of neutralizing antibodies against endogenous factor VIII. About half the cases are associated with pregnancy, postpartum, autoimmune diseases, malignancies, or adverse drug reactions. Symptoms include severe and unexpected bleeding that may prove life-threatening.Case Study. We report a case of AHA associated with bullous pemphigoid (BP), a chronic, autoimmune, subepidermal, blistering skin disease. To our knowledge, this is the 25th documented case of such an association. Following treatment for less than 3 months consisting of methylprednisolone at decreasing dose levels along with four courses of rituximab (monoclonal antibody directed against the CD20 protein), AHA was completely cured and BP well-controlled.Conclusions. This report illustrates a rare association of AHA and BP, supporting the possibility of eradicating the inhibitor with a well-conducted short-term treatment.

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