A case of spindle cell carcinoma of the breast: Morphological and immunohistochemical study.

Spindle cell carcinoma (SpC), also known as metaplastic carcinoma—spindle cell type, is a subtype of metaplastic carcinoma. Metaplastic carcinomas of the breast are rare but are thought to be more aggressive than invasive ductal carcinomas. Due to their rarity, there are few randomized trials that can inform any standardized approaches to treatment. Treatment is instead extrapolated from other types of breast cancer or metaplastic carcinomas of different locations. Here we present the first known case report of a patient with spindle cell carcinoma of the breast successfully treated with a standard sarcoma neoadjuvant regimen of doxorubicin, ifosfamide, and mesna (AIM) that resulted in >99% necrosis of the tumor and negative margins at the time of resection.

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An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast

Human Pathology ◽

10.1053/s0046-8177(03)00414-3 ◽

2003 ◽

Vol 34 (10) ◽

pp. 1009-1015 ◽

Cited By ~ 111

Author(s):

Barbara Dunne ◽

Andrew H.S Lee ◽

Sarah E Pinder ◽

Jane A Bell ◽

Ian O Ellis

Keyword(s):

Cell Carcinoma ◽

Spindle Cell ◽

Immunohistochemical Study ◽

Phyllodes Tumor ◽

Spindle Cell Carcinoma

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Low-Grade Fibromatosis-Like Spindle Cell Carcinoma of the Breast: a Mimicker of Benign Mesenchymal Tumors

Indian Journal of Surgery ◽

10.1007/s12262-020-02142-w ◽

2020 ◽

Author(s):

Hsing-Yu Chen ◽

Thi Minh Thuc Nguyen ◽

I-Wei Chang

Keyword(s):

Cell Carcinoma ◽

Spindle Cell ◽

Spindle Cell Carcinoma ◽

Low Grade ◽

Mesenchymal Tumors ◽

Carcinoma Of The Breast

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Low-Grade Fibromatosis-like Spindle Cell Carcinoma of the Breast

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2013-0555-rs ◽

2015 ◽

Vol 139 (4) ◽

pp. 552-557 ◽

Cited By ~ 28

Author(s):

Jessica B. Dwyer ◽

Beth Z. Clark

Keyword(s):

Local Recurrence ◽

Cell Carcinoma ◽

Spindle Cell ◽

Spindle Cell Carcinoma ◽

Definitive Diagnosis ◽

Low Grade ◽

Carcinoma Of The Breast ◽

Complete Excision ◽

Favorable Prognosis ◽

Spindle Cells

Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast. These tumors warrant distinction because of their resemblance to pure fibromatosis, their propensity for local recurrence, and their favorable prognosis among the metaplastic carcinomas of the breast. The diagnosis is potentially challenging, particularly on core needle biopsies, because of the morphologic overlap with other low-grade spindle cell lesions. Recognition of a proliferation of cytologically bland spindle cells with areas of epithelial differentiation in combination with immunohistochemistry using antibodies against cytokeratins and myoepithelial markers should aid in producing a definitive diagnosis. These tumors can be locally aggressive with an increased incidence of local recurrence, but the potential for lymph node or distant metastasis is low. Complete excision with adequate margins is considered curative in the majority of cases.

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