Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Seyed Amir Miratashi Yazdi ◽  
Marjan Heshmati ◽  
Mohammadreza Jalali Nadoushan
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Multinodular Goiter ◽  
Epithelial Membrane Antigen ◽  
Demographic Data ◽  
Lymph Node Involvement ◽  
Intensity Level ◽  
Papillary Thyroid ◽  
Node Involvement

Background: Papillary thyroid cancer is the most common type of thyroid malignancies. For a more accurate diagnosis, immunohistochemistry has been used widely in recent years. Epithelial membrane antigen has been detected in several benign and malignant lesions, and its use as a marker of malignancy has been sought in some studies. Objectives: The current study aimed to determine the presence and level of expression of epithelial membrane antigen in papillary thyroid carcinoma and multinodular goiter. Methods: Eighty-five samples of papillary thyroid carcinoma and 40 cases of multinodular goiter were stained histochemically for epithelial membrane antigen. The intensity of staining was classified in a semi-quantitative manner (1+ to 4+). Demographic data of the index cases, history of metastasis, and lymph node involvement, if any, were collected as well. Results: All PTCs and 87.5% of MNGs were positive for EMA. EMA was expressed more strongly in PTCs than in MNGs (P < 0.00). EMA reactivity was directly associated with lymph node involvement, capsular invasion, and size of the tumor (P = 0.008, P < 0.001, and P < 0.001, respectively). The intensity level of 2 or higher had high specificity for differentiating PTC from MNG. Conclusions: Strong expression of EMA may be a good marker of malignancy in differentiating PTC from MNG. This marker may also be regarded as an index of invasive behavior of PTC.

scholarly journals Langerhans Cell Histiocytosis of the Thyroid with Multiple Cervical Lymph Node Involvement Accompanying Metastatic Thyroid Papillary Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
A. Bahar Ceyran ◽  
Serkan Şenol ◽  
Barış Bayraktar ◽  
Şeyma Özkanlı ◽  
Z. Leyla Cinel ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Langerhans Cell Histiocytosis ◽  
Cervical Lymph Node ◽  
Lymph Node Involvement ◽  
Langerhans Cell ◽  
Papillary Thyroid ◽  
Thyroid Papillary ◽  
Node Involvement

A 37-year-old male case was admitted with goiter. Ultrasonography of thyroid showed a 5 cm cystic nodule in the left lobe with a 1.5 cm solid component. Fine needle aspiration biopsy revealed atypia of undetermined significance or follicular lesion. The patient was operated on. The pathological diagnosis was reported as papillary thyroid carcinoma. The immunohistochemical examination showed multiple foci of Langerhans cell histiocytosis involving both lobes. The patient died due to cardiac arrest with respiratory causes in the early postoperative period. Langerhans cell histiocytosis is a rare primary condition which involves abnormal clonal proliferation of Langerhans cells in various tissues and organs. Thyroid involvement is infrequently seen. Although the etiology is unknown, genetic components may be linked to the disease. It is also associated with a family history of thyroid disease. Papillary thyroid carcinoma is the most common malignant epithelial tumor of the thyroid gland. Langerhans cell histiocytosis presenting with papillary thyroid carcinoma is rare. The privilege of our case is langerhans cell histiocytosis of the thyroid with multiple cervical lymph node involvement accompanying cervical lymph node metastatic thyroid papillary carcinoma.

scholarly journals Isthmusectomy for well-differentiated thyroid carcinoma located to the isthmus: A report of two cases and review of the literature

Medwave ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. e8493-e8493
Author(s):  
Roberto Ignacio Olmos Borzone ◽  
Jorge Andrés López Ruiz-Esquide ◽  
Francisco Domínguez Covarrubias ◽  
José Miguel Domínguez Ruiz-Tagle
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Therapeutic Option ◽  
Lymph Node Involvement ◽  
Differentiated Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Node Involvement ◽  
Well Differentiated ◽  
Prophylactic Lymph Node Dissection

Papillary thyroid cancer is the most common endocrine malignancy, and due to its favorable prognosis, the extent of surgery has been a matter of debate. About 10% of these tumors are located in the thyroid isthmus, with no specific management in current guidelines. In the last decades, isthmusectomy has been proposed as a therapeutic option for isthmic papillary thyroid carcinoma, although there is no consensus on its management. We present two cases of patients from our institution with solitary isthmic papillary thyroid carcinoma without clinical macroscopic extrathyroidal extension or clinical-radiological lymph node involvement who were treated with isthmusectomy without prophylactic lymph node dissection. Neither of them had any postoperative complications. Both had an intermediate risk of recurrence due to aggressive variants. None of them had signs of recurrence during follow-up. We intend to show that isthmusectomy seems to be an effective and safe surgical alternative in selected patients through these cases.

Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence

2006 ◽  
Vol 46 (3) ◽  
pp. 307-313 ◽  
Author(s):  
Maura Massimino ◽  
Paola Collini ◽  
Silvia Fagundes Leite ◽  
Filippo Spreafico ◽  
Nicola Zucchini ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Surgical Approach ◽  
Lymph Node Involvement ◽  
Childhood And Adolescence ◽  
Papillary Thyroid ◽  
Node Involvement

scholarly journals High Preponderance of BRAF V600E Mutation in Papillary Thyroid Carcinoma Among Filipinos: A Clinicopathologic Study

2019 ◽  
pp. 1-6
Author(s):  
Gerard Anthony M. Espiritu ◽  
Joemari T. Malana ◽  
Arlie Jean Grace V. Dumasis ◽  
Daphne C. Ang
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf Mutation ◽  
Lymph Node Involvement ◽  
Extrathyroidal Extension ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Node Involvement

Purpose BRAF mutation in papillary thyroid carcinoma (PTC) is associated with an aggressive phenotype, with varying incidence. We evaluated the prevalence of BRAF mutations in PTC among Filipino patients and their correlation with clinicopathologic characteristics. Patients and Methods Clinicopathologic data were retrieved from 64 sequential patients who underwent thyroidectomy from June 2016 to December 2016. BRAF mutation testing was performed using Sanger sequencing. Results Eighteen (28%) of 64 patients were diagnosed with PTC; 12 (70.59%) of 17 harbored a BRAF V600E mutation (no amplification in one patient). Demographics of patients with PTC were as follows: 13 women and five men, with median age of 46 years (range, 25 to 74 years). Fourteen patients had conventional subtype PTC; two, follicular variant; one, oncocytic variant; and one, tall-cell features. Tumor size ranged from 0.8 to 7.0 cm (median, 2.4 cm); extrathyroidal extension was present in seven (38.9%) of 18 patients, multifocality in six (33.33%) of eight, and lymph node involvement in eight (44.4%) of 18. Significant association between presence of a BRAF mutation and presence of extrathyroidal extension or lymph node involvement was not determined due to the limited sample size. Conclusion The high preponderance of BRAF mutation (70.59%) suggests some correlation with the previously reported lower 5-year survival among Filipinos. This warrants further investigation in a larger-cohort prospective study.

Level I lymph node involvement in patients with N1b papillary thyroid carcinoma: a prospective study

2016 ◽  
Vol 274 (4) ◽  
pp. 1951-1958
Author(s):  
Ahmad M. Eweida ◽  
Mahmoud F. Sakr ◽  
Yasser Hamza ◽  
Mohamed R. Khalil ◽  
Essam Gabr ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Prospective Study ◽  
Lymph Node Involvement ◽  
Papillary Thyroid ◽  
Node Involvement ◽  
Level I ◽  
A Prospective Study
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